Effects of Docosahexaenoic Supplementation and<i>In Vitro</i>Vitamin C on the Oxidative and Inflammatory Neutrophil Response to Activation

Capó, Xavier; Martorell, Miquel; Sureda, Antoni; Tur, Josep A.; Pons, Antoni

doi:10.1155/2015/187849

Cited by 20 publications

(20 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been pointed out that exercise and ageing influence the degree of inflammation [48,49,50]. The present results showed that exercise, regardless of age or functional beverage supplementation, activates NFκβ in PBMCs that drives the cell to gene expression of pro-inflammatory cytokines, anti-oxidant enzymes and other genes [51,52]. The plasma levels of sL-selectin, sICAM3, Lipoxin, IL-6, TNFα, PGE2 are influenced by exercise [24,49], although their response to exercise are age and beverage dependent.…”

Section: Effects On Inflammatory Markersmentioning

confidence: 58%

Effects of Almond- and Olive Oil-Based Docosahexaenoic- and Vitamin E-Enriched Beverage Dietary Supplementation on Inflammation Associated to Exercise and Age

et al. 2016

Self Cite

View full text Add to dashboard Cite

n-3-polyunsaturated fatty acids and polyphenols are potential key factors for the treatment and prevention of chronic inflammation associated to ageing and non-communicable diseases. The aim was to analyse effects of an almond and olive oil beverage enriched with α-tocopherol and docosahexaenoic, exercise and age on inflammatory plasma markers, and immune gene expression in peripheral blood mononuclear cells (PBMCs). Five young and five senior athletes who were supplemented for five weeks with a functional beverage performed a stress test under controlled conditions before and after beverage supplementation. Blood samples were taken immediately before and 1 h after each test. Plasma, erythrocytes and PBMCs were isolated. Beverage supplementation increased plasmatic Tumour Necrosis Factor α (TNFα) levels depending on age and exercise. Exercise increased plasma non esterified fatty acids (NEFAs), soluble Intercellular adhesion molecule 3 (sICAM3) and soluble L-selectin (sL-Selectin), and this increase was attenuated by the supplementation. Exercise increased PGE2 plasma levels in supplemented young and in senior placebo athletes. Exercise increased NFkβ-activated levels in PBMCs, which are primed to a pro-inflammatory response increasing pro-inflammatory genes expression after the exercise mainly in the young group after the supplementation. The functional beverage supplementation to young athletes enhances a pro-inflammatory circulating environment in response to the exercise that was less evident in the senior group.

show abstract

Section: Effects On Inflammatory Markersmentioning

confidence: 58%

Effects of Almond- and Olive Oil-Based Docosahexaenoic- and Vitamin E-Enriched Beverage Dietary Supplementation on Inflammation Associated to Exercise and Age

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…This situation might probably reflect a lower basal ROS production by PBMCs as a result of the calorie restriction [16,49]. In fact, the expression of antioxidant enzymes is enhanced by ROS, such as hydrogen peroxide, in PBMCs [49], and this response is avoided by the antioxidant vitamin C in phorbol myristate acetate (PMA)-activated neutrophils [50]. Likewise, exercise training that enhances ROS production also increases the expression of HSP72 in PBMCs of premenopausal women [51].…”

Section: Discussionmentioning

confidence: 99%

Calorie Restriction Improves Physical Performance and Modulates the Antioxidant and Inflammatory Responses to Acute Exercise

et al. 2020

Self Cite

View full text Add to dashboard Cite

Our aim was to characterize the effects of calorie restriction on the anthropometric characteristics and physical performance of sportsmen and to evaluate the effects of calorie restriction and acute exercise on mitochondria energetics, oxidative stress, and inflammation. Twenty volunteer taekwondo practitioners undertook a calorie restriction of 30–40% on three alternate days a week for one month. Eleven volunteer sportsmen participated as controls. Both groups performed an energy efficiency test to evaluate physical performance, and samples were taken before and after exercise. The total weight of participants significantly decreased (5.9%) after calorie restriction, while the efficiency of work and the contributions of fat to obtain energy were enhanced by calorie restriction. No significant differences induced by acute exercise were observed in individual non-esterified fatty acid percentage or oxidative stress markers. Calorie restriction downregulated the basal gene expression of nitric oxide synthase, antioxidant enzymes, mitochondrial uncoupling proteins, and repairing stress proteins, but it enhanced the expression of sirtuins in peripheral blood mononuclear cells. In conclusion, one month of calorie restriction decreases body weight and increases physical performance, enhancing energy efficiency, moderating the antioxidant and inflammatory basal gene expression, and influencing its response to acute exercise.

show abstract

“…Obtaining a skeletal muscle involves an invasive procedure and for this reason various authors use erythrocyte FAs composition as an analogous measure to assess the efficacy of nutritional intervention trials to incorporate FAs into tissues [11, 24-26, 38, 50, 51]. Few studies compare muscle and erythrocyte FAs composition [16-19]; our research is, to the best of our knowledge, the ﬁrst ever to compare the FAs composition of muscle and erythrocytes in adult humans in post-exercise conditions and after a CR period.…”

Section: Discussionmentioning

confidence: 99%

Erythrocytes and Skeletal Muscle Unsaturated and Omega-6 Fatty Acids Are Positively Correlated after Caloric Restriction and Exercise

Martorell

Pons²,

Domingo

et al. 2018

Ann Nutr Metab

Self Cite

View full text Add to dashboard Cite

Background: Nutritional intervention studies with fatty acid (FA) supplements assess the efficacy of the intervention by measuring the changes in erythrocyte membrane lipid profiles reflected in tissue composition changes. The aim was to determine the effects of caloric restriction (CR) on erythrocytes lipid composition and to compare and correlate these changes with skeletal muscle acid profiles after CR. Methods: Erythrocytes were obtained from 11 healthy men before and after 4 weeks of 33% CR in post-exercise conditions; muscle biopsies were obtained from the same athletes after 4 weeks of 33% CR in post-exercise conditions. Samples were used for FA determination by chromatography. Results: CR significantly modified erythrocyte FAs composition. Skeletal muscle FA profile was significantly different from that for the erythrocytes. The erythrocyte FA profile was more saturated (52.1 ± 1.5% and 32.8 ± 0.9%, respectively) and less monounsaturated (21.0 ± 0.8% and 39.0 ± 2.0%, respectively) than the skeletal muscle FA profile and similarly polyunsaturated. Conclusions: CR modifies erythrocyte lipid composition, mainly omega-6 FAs. Erythrocyte monounsaturated, polyunsaturated and omega-6 FAs, but not the saturated and omega-3 FAs, were significantly positively correlated with skeletal muscle FAs. There is a discordance between saturated and omega-3 FAs from erythrocyte and from muscle, but monounsaturated, polyunsaturated and omega-6 fatty acids are positively correlated.

show abstract

Effects of Docosahexaenoic Supplementation andIn VitroVitamin C on the Oxidative and Inflammatory Neutrophil Response to Activation

Cited by 20 publications

References 63 publications

Effects of Almond- and Olive Oil-Based Docosahexaenoic- and Vitamin E-Enriched Beverage Dietary Supplementation on Inflammation Associated to Exercise and Age

Effects of Almond- and Olive Oil-Based Docosahexaenoic- and Vitamin E-Enriched Beverage Dietary Supplementation on Inflammation Associated to Exercise and Age

Calorie Restriction Improves Physical Performance and Modulates the Antioxidant and Inflammatory Responses to Acute Exercise

Erythrocytes and Skeletal Muscle Unsaturated and Omega-6 Fatty Acids Are Positively Correlated after Caloric Restriction and Exercise

Contact Info

Product

Resources

About