Effects of donkey milk on oxidative stress and inflammatory response

Li, Yan; Ma, Qingshan; Liu, Guiqin; Wang, Changfa

doi:10.1111/jfbc.13935

Cited by 21 publications

(13 citation statements)

References 107 publications

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“…Additionally, Donkey milk inhibits gluconeogenesis by regulating the expression levels of phosphoenolpyruvate carboxykinase 1 and glucose-6 phosphatase. Donkey milk enhances the antioxidant defense mechanisms by which it protects the development of insulin resistance 38 . Lactose, whey protein and bioactive peptides in DM have been shown to be involved in insulin response to glucose.…”

Section: Donkey Milkmentioning

confidence: 99%

“…Camel milk is well known for its anti-diabetic, anti-carcinogenic, immunomodulatory, and anti-microbial effect 65 . Donkey milk is gaining attention as a natural nutritional and medicinal product, mainly because its composition is parallel to that of human milk and it has some potential biological properties, such as antioxidant, antiinflammatory, antiaging, antimicrobial, and antiallergic 38 .…”

mentioning

confidence: 99%

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Modern health concept of non-bovine milk: A review

Wadhwani¹,

Bhavsar²,

Islam³

et al. 2023

ijapm

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Milk is considered as the most complete single food available and is a fundamental part of the human diet in which major contribution comes from bovine than that of Non-Bovine Animals (NBA). Among NBAs, goat, camel, and donkey are important components of livestock industry which play vital role in the socio-economic structure in rural areas. The gross composition of the Non-Bovine Milk (NBM) is almost like that of bovine milk, except donkey milk due to its lower fat and protein and higher lactose content. NBM has several health benefits as it is rich source of essential fatty acids, some essential amino acids, micro-nutrients, and several bioactive compounds. Goat and camel milk have smaller fat globules hence known as naturally homogenized milk and have better digestibility and protein utilization. Camel and donkey milk are rich source of vitamin C as compared to bovine milk. Furthermore, the protein composition of NBM is one of the attractive points as compared to bovine milk due to its lower allergenic effects in consumers. NBM is also a very rich source of healthy unsaturated fatty acids. Multiple medicinal and therapeutic anti-allergic, anti-microbial, anti-inflammatory, anti-oxidative and anti-cancerous properties help to promote them as “functional foods” to attract consumers. Goat, camel and donkey milk are well known for their bifidogenic, anti-diabetic and antioxidant effects, respectively. NBM has potential for human well-being though, less awareness, information about the microbiota and its significance for milk quality and safety are challenging fields for further exploration.

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Section: Donkey Milkmentioning

confidence: 99%

mentioning

confidence: 99%

Modern health concept of non-bovine milk: A review

Wadhwani¹,

Bhavsar²,

Islam³

et al. 2023

ijapm

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“…Donkey milk is enriched with bioactive and anti-infective factors and is characterized by its palatability, digestibility, and hypoallergenicity. Owing to these qualities, donkey milk can be used as an effective alternative food for neonates, and owing to its broad-spectrum functional activities (which include anti-inflammatory, antioxidant, and antiaging activities), a medicinal and food homology that meets the nutritional needs of people in different physiological states . Notably, donkey milk has a smaller volume of milk fat globule (MFG) than human milk, with an average diameter of 1.50 μm compared to 5.19 μm for human MFG .…”

Section: Introductionmentioning

confidence: 99%

“…Owing to these qualities, donkey milk can be used as an effective alternative food for neonates, and owing to its broad-spectrum functional activities (which include antiinflammatory, antioxidant, and antiaging activities), a medicinal and food homology that meets the nutritional needs of people in different physiological states. 1 Notably, donkey milk has a smaller volume of milk fat globule (MFG) than human milk, with an average diameter of 1.50 μm compared to 5.19 μm for human MFG. 2 A smaller MFG diameter per unit volume implies a larger specific surface area of the milk fat globule membrane (MFGM), which may contribute to the interaction between host enzymes and the functionally active components of the MFGM, promoting the higher digestion and absorption rate of donkey MFGM in the body.…”

Section: Introductionmentioning

confidence: 99%

Comparative Site-Specific O-Glycosylation Analysis of the Milk Fat Globule Membrane Proteome in Donkey Colostrum and Mature Milk

Guan,

Cao,

Yang

et al. 2024

J. Agric. Food Chem.

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Donkey milk fat globule membrane (MFGM) proteins are a class of membrane-bound secreted proteins with broadspectrum biofunctional activities; however, their site-specific O-glycosylation landscapes have not been systematically mapped. In this study, an in-depth MFGM O-glycoproteome profile of donkey milk during lactation was constructed based on an intact glycopeptide-centered, label-free glycoproteomics pipeline, with 2137 site-specific O-glycans from 1121 MFGM glycoproteins and 619 site-specific O-glycans from 217 MFGM glycoproteins identified in donkey colostrum and donkey mature milk, respectively. As lactation progressed, the number of site-specific O-glycans from three glycoproteins significantly increased, whereas that of 11 sitespecific O-glycans from five glycoproteins significantly decreased. Furthermore, donkey MFGM O-glycoproteins with core-1 and core-2 core structures and Lewis and sialylated branch structures may be involved in regulating apoptosis. The findings of this study reveal the differences in the composition of donkey MFGM O-glycoproteins and their site-specific O-glycosylation modification dynamic change rules during lactation, providing a molecular basis for understanding the complexity and biological functions of donkey MFGM protein O-glycosylation.

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“…The traditional use of donkey milk for the treatment of many illnesses has been reported in China, South America, and some African societies Fantuz, 2013, 2022;Papademas et al, 2022). In recent years, the donkey has gained interest as a species producing dairy foods for consumers sensitive to cow milk, such as infants, adults with inflammatory or allergic ailments, and healthy older people (Miraglia et al, 2020;Li et al, 2021;Papademas et al, 2022;Salimei and Fantuz, 2022). Clinical studies have shown that donkey milk can be used, when adequately supplemented, for children with IgE-and non-IgE-mediated cow milk allergy (Mansueto et al, 2013;Salimei and Fantuz, 2013;Sarti et al, 2019).…”

Section: Introductionmentioning

confidence: 99%