2021
DOI: 10.1016/j.healun.2021.01.1063
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Effects of Donor Smoking History on Early Post-Transplant Lung Function Measured by Oscillometry

Abstract: Purpose: The CYP3A5*1 polymorphism, predominant in African Americans (AAs), and drug interactions with CYP3A inhibitors/inducers significantly impact tacrolimus metabolism. Minimal data evaluating tacrolimus dose requirements (TDRs) in lung transplant recipients (LTRs) on concurrent strong CYP3A inhibitors exists. We sought to assess the effect of race on TDRs and transplantation outcomes in a cohort of LTRs initiated on a fixed tacrolimus dose and antifungal prophylaxis with a systemic azole after transplant.… Show more

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“…A combination of older donor and smoking history of about 20-pack-years may result in inferior outcomes [30]. Objectively, differences in parameters of small airway obstruction and pulmonary function test (PFT) at 8 weeks postoperatively are not significant between the donors with smoking history and those without smoking history [33].…”
Section: Smokingmentioning
confidence: 99%
“…A combination of older donor and smoking history of about 20-pack-years may result in inferior outcomes [30]. Objectively, differences in parameters of small airway obstruction and pulmonary function test (PFT) at 8 weeks postoperatively are not significant between the donors with smoking history and those without smoking history [33].…”
Section: Smokingmentioning
confidence: 99%