Effects of dopamine D-1 and D-2 antagonists on decision making by rats: No reversal of neuroleptic-induced attenuation by scopolamine

Ljungberg, Tomas; Enquist, Magnus

doi:10.1007/bf01272760

Cited by 4 publications

(4 citation statements)

References 32 publications

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“…We note that unlike other published reports [71, 72], the effects of the DA D 1 agonist/antagonist on decision making were modest at best ( Fig. S2 ), but not uncommon [73–75]. In our case, the DA D 1 agonist and antagonist had a noticeable effect on motivation which was further supported with the photometric analysis of DA release in the NAc.…”

Section: Discussionsupporting

confidence: 86%

“…We note that unlike other published reports [71,72], the effects of the DA D1 agonist/antagonist on decision making were modest at best (Fig. S2), but not uncommon [73][74][75].…”

Section: α2a Adrenoceptor Modulation Of Stress Induced Catecholamine ...contrasting

confidence: 94%

“…Our finding that systemic injections of yohimbine reduced the BLA-NE signal without affecting decision strategy is consistent with this hypothesis. We note that unlike other published reports [84, 85], the effects of the DA D 1 agonist/antagonist on decision making were modest at best, but not uncommon [86–88]. In our case, the DA D 1 agonist and antagonist had a noticeable effect on motivation which was further supported with the photometric analysis of DA release in the NAc.…”

Section: Discussionsupporting

confidence: 82%

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Noradrenergic modulation of stress induced catecholamine release: Opposing influence of FG7142 and yohimbine

Visocky,

Turner,

Lowrie

et al. 2024

Preprint

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In humans, loss aversion is sensitive to stress, and patients with neurological or psychiatric illnesses are particularly vulnerable to the detrimental effects of stress that lead to suboptimal life-altering choices. The basolateral amygdala (BLA) and nucleus accumbens (NAc) are stress sensitive brain areas that alter extracellular levels of norepinephrine (NE) and dopamine (DA), respectively. However, the dynamics of neurotransmitter release in these brain regions during stress has not been systematically explored. We used pharmacology and fiber photometric analysis to elucidate the impact of stress, DA and NE on brain activity during decision making behavior. Long-Evans rats were trained on an operant touchscreen decision-making task in which they chose between a safe stimulus that delivered a certain 50ul sucrose, or a risky stimulus that delivered either a loss (10ul sucrose 75% of the time) or win (170ul sucrose 25% of the time). Stress, induced by an inverse GABAA agonist, FG7142, biased rats decisions towards safety due to increased loss sensitivity. The aversion to loss was blocked with co-treatment of the alpha 2A receptor antagonist, yohimbine. We also captured the rapid dynamic properties of stress induced changes in NE and DA release in the BLA and NAc, respectively. We discovered that these dynamics could be modulated with systemic injections of yohimbine by altering stress induced catecholamine release to optimize decision strategy and motivational state.

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Section: Discussionsupporting

confidence: 86%

“…We note that unlike other published reports [71,72], the effects of the DA D1 agonist/antagonist on decision making were modest at best (Fig. S2), but not uncommon [73][74][75].…”

Section: α2a Adrenoceptor Modulation Of Stress Induced Catecholamine ...contrasting

confidence: 94%

Section: Discussionsupporting

confidence: 82%

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Noradrenergic modulation of stress induced catecholamine release: Opposing influence of FG7142 and yohimbine

Visocky,

Turner,

Lowrie

et al. 2024

Preprint

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“…For the remaining rats (N = 11), decision making was assessed 10 min after administration of the selective D1 receptor antagonist SCH23390 (0.03 mg/kg; Bourne, 2001) or saline. Doses used were similar to those used in previous studies of reinforcement learning (Ljungberg and Enquist, 1990;Keeler et al, 2014) and do not produce motoric or behavioral impairments that are observed with higher doses of these drugs (Collins et al, 1991;Mattingly et al, 1993). Choice behavior following administration of sulpiride, SCH 23390, or saline was analyzed using the same reinforcementlearning algorithm described above.…”

Section: Pharmacological Studies Of Dopamine Receptorsmentioning

confidence: 99%

Chronic Exposure to Methamphetamine Disrupts Reinforcement-Based Decision Making in Rats

Groman

Rich

Smith

et al. 2017

Neuropsychopharmacol.

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The persistent use of psychostimulant drugs, despite the detrimental outcomes associated with continued drug use, may be because of disruptions in reinforcement-learning processes that enable behavior to remain flexible and goal directed in dynamic environments. To identify the reinforcement-learning processes that are affected by chronic exposure to the psychostimulant methamphetamine (MA), the current study sought to use computational and biochemical analyses to characterize decision-making processes, assessed by probabilistic reversal learning, in rats before and after they were exposed to an escalating dose regimen of MA (or saline control). The ability of rats to use flexible and adaptive decision-making strategies following changes in stimulus-reward contingencies was significantly impaired following exposure to MA. Computational analyses of parameters that track choice and outcome behavior indicated that exposure to MA significantly impaired the ability of rats to use negative outcomes effectively. These MA-induced changes in decision making were similar to those observed in rats following administration of a dopamine D2/3 receptor antagonist. These data use computational models to provide insight into drug-induced maladaptive decision making that may ultimately identify novel targets for the treatment of psychostimulant addiction. We suggest that the disruption in utilization of negative outcomes to adaptively guide dynamic decision making is a new behavioral mechanism by which MA rigidly biases choice behavior.

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Microcatalepsy and disruption of forelimb usage during operant behavior: differences between dopamine D1 (SCH-23390) and D2 (raclopride) antagonists

Fowler

Liou

1994

Psychopharmacology

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In an experiment designed to distinguish between the behavioral consequences of treatment with SCH-23390, a D1 dopamine receptor blocker, and raclopride, a D2 antagonist, rats were trained to perform a water-reinforced forelimb operant response. Response rate and the duration of each forelimb contact with the operandum were recorded. In addition, the durations of the rat's visits to the reward well were detected by a photobeam which was blocked by the rat's muzzle as it remained at the reward well. In a between-groups dosing design, separate groups of rats (11-13 rats/group) received SCH-23390 (0, 0.01, 0.02, 0.04, 0.08, 0.12 mg/kg, IP, 30 min) or raclopride (0. 0.05, 0.1, 0.2, 0.4, 0.8 mg/kg, IP, 30 min) for 21 consecutive days. Quantitative analyses indicated that for comparable amounts of operant rate reduction, raclopride had a significantly greater tendency than SCH-23390 to increase the duration of operant responses and to increase the maximum muzzle entry duration (i.e., to induce microcatalepsy). The results support the idea that at relatively low doses D2 antagonism is more likely than D1 antagonism to produce effects identified preclinically with extrapyramidal side effects.

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Effects of dopamine D-1 and D-2 antagonists on decision making by rats: No reversal of neuroleptic-induced attenuation by scopolamine

Cited by 4 publications

References 32 publications

Noradrenergic modulation of stress induced catecholamine release: Opposing influence of FG7142 and yohimbine

Noradrenergic modulation of stress induced catecholamine release: Opposing influence of FG7142 and yohimbine

Chronic Exposure to Methamphetamine Disrupts Reinforcement-Based Decision Making in Rats

Microcatalepsy and disruption of forelimb usage during operant behavior: differences between dopamine D1 (SCH-23390) and D2 (raclopride) antagonists

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