Effects of dopamine D1- and D2-like receptors in the CA1 region of the hippocampus on expression and extinction of morphine-induced conditioned place preference in rats

Nazari-Serenjeh, Farzaneh; Zarrabian, Shahram; Azizbeigi, Ronak; Haghparast, Abbas

doi:10.1016/j.bbr.2020.112924

Cited by 11 publications

(3 citation statements)

References 30 publications

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“…This coincidence probably reflects the existence of hippocampal-amygdalar interdependencies that could affect the extinction of fear expression in isolated extinguished animals. The changes in the CA1 area of the hippocampus are similar to previous research that indicated the important role of D 2 R in the extinction of appetitive stimuli [43].…”

Section: Discussionsupporting

confidence: 88%

The effects of the recurrent social isolation stress on fear extinction and dopamine D2 receptors in the amygdala and the hippocampus

et al. 2022

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Background The present study assessed the influence of recurrent social isolation stress on the aversive memory extinction and dopamine D2 receptors (D2R) expression in the amygdala and the hippocampus subnuclei. We also analyzed the expression of epigenetic factors potentially associated with fear extinction: miRNA-128 and miRNA-142 in the amygdala. Methods Male adult fear-conditioned rats had three episodes of 48 h social isolation stress before each fear extinction session in weeks intervals. Ninety minutes after the last extinction session, the D2R expression in the nuclei of the amygdala and the hippocampus (immunocytochemical technique), and mRNA levels for D2R in the amygdala were assessed (PCR). Moreover, we evaluated the levels of miRNA-128 and miRNA-142 in the amygdala. Results It was found that recurrent social isolation stress decreased the fear extinction rate. The extinguished isolated rats were characterized by higher expression of D2R in the CA1 area of the hippocampus compared to the extinguished and the control rats. In turn, the isolated group presented higher D2R immunoreactivity in the CA1 area compared to the extinguished, the control, and the extinguished isolated animals. Moreover, the extinguished animals had higher expression of D2R in the central amygdala than the control and the extinguished isolated rats. These changes were accompanied by the increase in miRNA-128 level in the amygdala in the extinguished isolated rats compared to the control, the extinguished, and the isolated rats. Moreover, the extinguished rats had lower expression of miRNA-128 compared to the control and the isolated animals. Conclusions Our results suggest that social isolation stress impairs aversive memory extinction and coexists with changes in the D2R expression in the amygdala and hippocampus and increased expression of miRNA-128 in the amygdala.

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Section: Discussionsupporting

confidence: 88%

The effects of the recurrent social isolation stress on fear extinction and dopamine D2 receptors in the amygdala and the hippocampus

et al. 2022

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“…While the roles of factors influencing drug-context learning and memory have been assessed in male rodents, this has been understudied in females. However, the ample sex differences in the organization and function of the hippocampus and nucleus accumbens (Nestler, 2001; Forlano & Woolley, 2010; Kutlu & Gould, 2016; Yagi et al ., 2022) increase the likelihood of sex differences in how environmental features affect the interoceptive effects of drugs, as well as the strength and stability of context-dependent drug associations (Forlano & Woolley, 2010; Kobrin et al ., 2016; Kutlu & Gould, 2016; Alvandi et al ., 2017; Nazari-Serenjeh et al ., 2021; Trott et al ., 2022). For example, females have greater distal dendritic spine density and proportion of large spines in the NAc compared to males, which may enhance the strength or efficiency of glutamatergic synapses from the hippocampus and other regions (Forlano & Woolley, 2010).…”

Section: Discussionmentioning

confidence: 99%

Morphine-context associative memory and locomotor sensitization in mice are modulated by sex and context in a dose-dependent manner

Hámor,

Hartmann,

Garcia

et al. 2023

Preprint

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Sex differences in opioid use, development of opioid used disorder, and relapse behaviors indicate potential variations in opioid effects between men and women. The locomotor and interoceptive effects of opioids play essential roles in opioid addiction, and uncovering the neural mechanisms underlying these effects remain crucial for developing effective treatments. In this study, we examined the dose-dependent effects of morphine on locomotor sensitization and the strength and stability of morphine-context associations in the conditioned place preference (CPP) paradigm in male and female mice, as well as the relationships between these measures. We observed that while CPP is similar between sexes, the locomotor effects of repeated morphine administration and withdrawal differentially contributed to the strength and stability of morphine-context associations. Specifically, females exhibited higher morphine-induced hyperlocomotion than males regardless of the context in which morphine was experienced. Greater locomotor sensitization to morphine in females than males emerged in a dose-dependent manner only when there was sufficient context information for CPP to be established. Additionally, the relationships between the locomotor effects of morphine and the strength and stability of CPP were different in males and females. In females, positive acute and sensitizing locomotor effects of morphine were correlated with a higher CPP score, while the opposite direction of this relationship was found in males. These results suggest that different aspects of the subjective experience of morphine intoxication and withdrawal are important for morphine abuse-related behaviors and highlight the importance of sex-specific responses in the context of opioid addiction.

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“…There is a link between CA1 and reward regions of the brain, and this region has been shown to mediate morphine reward effects. [ 7 ] A functional loop exists between the CA1 and VTA that is one of the sources of dopaminergic neurons to the hippocampus. Therefore, long-term usage of tramadol may create dependence and tolerance through affecting CA1, in addition to the other part of reward circuits.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Orexin-2 and Endocannabinoid-1 Antagonists on Neuronal Activity of Hippocampal CA1 Pyramidal Neurons in Response to Tramadol in Rats

Reisi

Imanpour

2022

Advanced Biomedical Research

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Background: CA1, as a major structure involved in learning and memory, has been shown to be affected by tramadol addiction. Both orexin and endocannabinoid receptors express in CA1 and play an important role in drug dependency. The aim of this study was to evaluate the modulatory effects of orexin-2 (OX2R) and endocannabinoid-1 (CB1R) receptors on neuronal activity in CA1, in response to tramadol in rats. Materials and Methods: Male Wistar rats were divided into 8 groups ( n = 6–7); saline-dimethyl sulfoxide (DMSO), tramadol-DMSO, saline-TCS-OX2-29, saline-AM251, tramadol-TCS-OX2-29, tramadol-AM251, saline-TCS-OX2-29-AM251, tramadol-TCS-OX2-29-AM251. Tramadol was injected intraperitoneally, and then, AM251 (1 nmol/0.3 μL), CB1R antagonist and TCS-OX2-29 (1 nmol/0.3 μL), OX2R antagonist, were microinjected individually or concurrently into the CA1. Using in vivo extracellular single-unit recording, the firing of CA1 pyramidal neurons was investigated. Results: Tramadol decreased neuronal activity in CA1 ( P < 0.01) but increased it after micro-injection of DMSO. TCS-OX2-29 increased neuronal activity in saline group ( P < 0.05) but decreased it in tramadol group. AM251 had no effect on saline group but decreased neuronal activity in tramadol group ( P < 0.05). Concurrent micro-injection of TCS-OX2-29 and AM251 had no effect on saline group but decreased neuronal activity in tramadol group ( P < 0.05). Conclusions: Our findings suggest that neural activity in CA1 is rapidly affected by acute use of tramadol, and some of these effects may be induced through the endocannabinoid and orexin systems. Thus, the function of endocannabinoid and orexin systems in CA1 may play a role in tramadol addiction.

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Effects of dopamine D1- and D2-like receptors in the CA1 region of the hippocampus on expression and extinction of morphine-induced conditioned place preference in rats

Cited by 11 publications

References 30 publications

The effects of the recurrent social isolation stress on fear extinction and dopamine D2 receptors in the amygdala and the hippocampus

The effects of the recurrent social isolation stress on fear extinction and dopamine D2 receptors in the amygdala and the hippocampus

Morphine-context associative memory and locomotor sensitization in mice are modulated by sex and context in a dose-dependent manner

The Effect of Orexin-2 and Endocannabinoid-1 Antagonists on Neuronal Activity of Hippocampal CA1 Pyramidal Neurons in Response to Tramadol in Rats

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