Effects of dopamine on exocrine secretion and cyclic nucleotide concentration in the dog pancreas

Iijima, Fujio; Iwatsuki, Kazuhiko; Chiba, Shigetoshi

doi:10.1016/0014-2999(83)90286-8

Cited by 22 publications

(11 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…126 Pancreatic acinar cells have been shown to express receptors for dopamine. In the dog, the effect of dopamine is blocked by dopamine receptor antagonists but is unaffected by αor β-receptor antagonists.…”

Section: Dopaminementioning

confidence: 99%

“…126 Pancreatic acinar cells have been shown to express receptors for dopamine. 121,126 This effect is inhibited in rats by propranolol but not by the dopamine receptor antagonist haloperidol, indicating that the effects of dopamine are mediated through the β-adrenergic receptor rather than the dopamine receptor. However, dopamine causes very little enzyme secretion from either acinar cells in vitro or the pancreas in vivo.…”

Section: Dopaminementioning

confidence: 99%

See 1 more Smart Citation

Regulation of Pancreatic Secretion

Liddle¹

2012

Physiology of the Gastrointestinal Tract

View full text Add to dashboard Cite

show abstract

Section: Dopaminementioning

confidence: 99%

Section: Dopaminementioning

confidence: 99%

Regulation of Pancreatic Secretion

Liddle¹

2012

Physiology of the Gastrointestinal Tract

View full text Add to dashboard Cite

show abstract

“…The effects of dopamine on exocrine pancreatic secretion have been studied in several animal species (31,32). While a strong stimulatory effect on secretion was found in dogs (33)(34)(35), the effect was less pronounced in other species and is unclear in humans (36).…”

Section: Methodsmentioning

confidence: 99%

A novel nonneuronal catecholaminergic system: exocrine pancreas synthesizes and releases dopamine.

Mezey

Eisenhofer

Harta

et al. 1996

Proc. Natl. Acad. Sci. U.S.A.

114

View full text Add to dashboard Cite

Cells of the exocrine pancreas produce digestive enzymes potentially harmful to the intestinal mucosa. Dopamine has been reported to protect against mucosal injury. In looking for the source of dopamine in the small intestine, we found that the duodenal juice contains high levels of dopamine and that the pancreas itself has a high dopamine [and dihydroxyphenylalanine (dopa)] content that does not change significantly after chemical sympathectomy. Furthermore, we were able to demonstrate tyrosine hydroxylase (TH) activity in control pancreas as well as in pancreas from rats after chemical sympathectomy. Immunostaining and in situ hybridization histochemistry confirmed both the presence of TH, dopamine, and the dopamine transporter, and the mRNAs encoding TH and dopamine transporter, and the presence of both types ofvesicular monoamine transporters in the exocrine cells of the pancreas. Since there are no catecholaminergic enteric ganglia in the pancreas, the above results indicate that pancreatic cells have all the characteristics of dopamine-producing cells. We suggest that the pancreas is an important source of nonneuronal dopamine in the body, and that this dopamine has a role in protecting the intestinal mucosa and suggests that dopamine Dlb receptor agonists might be used to help mucosal healing in the gastrointestinal tract. Dopamine protects against both gastric and intestinal mucosal injury. For instance, gastric and duodenal ulcers heal significantly faster after administration of dopamine agonists (1-4). However, the possible source of dopamine in the gastrointestinal system remained to be determined.The exocrine pancreas produces and secretes digestive enzymes and bicarbonate and releases them into the duodenum, while endocrine cells in the islets of Langerhans synthesize and release hormones (such as insulin, glucagon, etc.) and are embedded in the exocrine pancreas. If dopamine in fact plays a protective role in the duodenum, then corelease with digestive enzymes from the exocrine pancreas seems reasonable. In the cells that are outside of the central nervous system, dopamine is generally considered to be a precursor of norepinephrine and epinephrine. Recent studies in swine (5), however, suggest that the mesenteric organs produce about half of total body dopamine and that dopamine in the mesenteric organs must not be exclusively a precursor to norepinephrine. The source of this dopamine is still unknown. We have recently discovered that the acid-secreting parietal cells of the stomach synthesize and release dopamine into the gastric lumen, where it may act as a paracrine hormone at dopamine receptors on epithelial cells (unpublished results). To determine if a similar mechanism exists in other parts of the digestive system, we analyzed both the pancreatic/duodenal secretions for the presence of dopamine and the pancreas itself for dopaminergic markers. METHODSSample Collection. To collect pancreatic/duodenal juice from rats, we ligated the duodenum near the pylorus to eliminate the contribut...

show abstract

“…However, Burnstock 426 F. Yamugishi et al (1978) postulated that purine-related compounds act on two types of receptors: PI-and Pzreceptors with the former being involved in the activation or inhibition of adenylate cyclase (Schrader et al 1977;Londos & Wolff 1977;Londos et al 1980). Similarly in this study secretin and dopamine were used as secretagogues, since both secretagogues mainly stimulate water and electrolyte secretion (Furuta et al 1972) but differ in their activation of adenylate cyclase Case & Scratchered 1972;Iijima et al 1983). This study attempts to extend speculations to th?…”

Section: Introductionmentioning

confidence: 88%

“…With regard to dopamine-stimulated hydromineral secretion, an increase in tissue cyclic AMP after dopamine was reported for the rat pancreas (Vaysse et a/. 1978) but not for the dog pancreas (Iijima et a/. 1983).…”

mentioning

confidence: 94%

Effects of Three Purine‐related Compounds on Pancreatic Exocrine Secretion in the Dog

Yamagishi

Homma

Haruta

et al. 1986

Clin Exp Pharma Physio

View full text Add to dashboard Cite

The effects of adenosine, adenosine 5'-triphosphate (ATP) and inosine on pancreatic exocrine secretion were investigated in the vascularly isolated and self-haemoperfused dog pancreas. Drugs were injected close-arterially (i.a.) in a single bolus. These three purine-related compounds per se did not affect resting rate of pancreatic secretion and the concentrations of protein and bicarbonate in the resting juice. Graded doses of adenosine (0.1-1.0 mg, i.a.) and ATP (0.1-1.0 mg i.a.) administered 1 min prior to secretin (0.025 clinical units, i.a.) increased a secretin-stimulated secretory volume dose-dependently, and the effects of adenosine and ATP were reversed by pretreatments with theophylline (0.3 mg, i.a.). Inosine (1.0 mg, i.a.) affected neither secretin- nor dopamine-stimulated (3 micrograms, i.a.) pancreatic secretion. Adenosine and ATP did not affect dopamine-stimulated pancreatic secretion. These results suggest that adenosine and ATP (or terminal phosphate hydrolyzed derivatives) enhance secretin-stimulated pancreatic exocrine secretion through 'P1' purine receptors in the exocrine cells, without conversion to inosine.

show abstract

Effects of dopamine on exocrine secretion and cyclic nucleotide concentration in the dog pancreas

Cited by 22 publications

References 18 publications

Regulation of Pancreatic Secretion

Regulation of Pancreatic Secretion

A novel nonneuronal catecholaminergic system: exocrine pancreas synthesizes and releases dopamine.

Effects of Three Purine‐related Compounds on Pancreatic Exocrine Secretion in the Dog

Contact Info

Product

Resources

About