Effects of dopamine receptor agonist and antagonists on cholestasis-induced anxiolytic-like behaviors in rats

Zarrindast, Mohammad Reza; Esfahani, Delaram Eslimi; Oryan, S; Nasehi, Mohammad; Nami, Mohammad

doi:10.1016/j.ejphar.2013.01.023

Cited by 21 publications

(11 citation statements)

References 70 publications

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“…1D; t 8 = 2.508; P = 0.0365). In accordance with previous study7071, There was no significant difference for the body weight between the sham and BDL rats within 1 to 15 days after BDL surgery (Fig. 1E; F (1,52) = 0.1752; P = 0.6772).…”

Section: Resultssupporting

confidence: 92%

Peripheral and spinal 5-HT receptors participate in cholestatic itch and antinociception induced by bile duct ligation in rats

Tian

Wang

Huang

et al. 2016

Sci Rep

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Although 5-HT has been implicated in cholestatic itch and antinociception, two common phenomena in patients with cholestatic disease, the roles of 5-HT receptor subtypes are unclear. Herein, we investigated the roles of 5-HT receptors in itch and antinociception associated with cholestasis, which was induced by common bile duct ligation (BDL) in rats. 5-HT-induced enhanced scratching and antinociception to mechanical and heat stimuli were demonstrated in BDL rats. 5-HT level in the skin and spinal cord was significantly increased in BDL rats. Quantitative RT-PCR analysis showed 5-HT1B, 5-HT1D, 5-HT2A, 5-HT3A, 5-HT5B, 5-HT6, and 5-HT7 were up-regulated in peripheral nervous system and 5-HT1A, 5-HT1F, 5-HT2B, and 5-HT3A were down-regulated in the spinal cord of BDL rats. Intradermal 5-HT2, 5-HT3, and 5-HT7 receptor agonists induced scratching in BDL rats, whereas 5-HT3 agonist did not induce scratching in sham rats. 5-HT1A, 5-HT2, 5-HT3, and 5-HT7 agonists or antagonists suppressed itch in BDL rats. 5-HT1A agonist attenuated, but 5-HT1A antagonist enhanced antinociception in BDL rats. 5-HT2 and 5-HT3 agonists or antagonists attenuated antinociception in BDL rats. Our data suggested peripheral and central 5-HT system dynamically participated in itch and antinociception under cholestasis condition and targeting 5-HT receptors may be an effective treatment for cholestatic itch.

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Section: Resultssupporting

confidence: 92%

Peripheral and spinal 5-HT receptors participate in cholestatic itch and antinociception induced by bile duct ligation in rats

Tian

Wang

Huang

et al. 2016

Sci Rep

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“…In accordance with the study by Nelson et al, 12 we measured the nociceptive thresholds at days 4, 6, and 8 after BDL surgery in this study, and several studies had proved that there was no significant difference between BDL models and controls on locomotor activity, rearing and grooming behaviors, defecations, and body weight within 10 to 13 days after BDL surgery. [27][28][29] Hence, it can be conclude that the change in nociceptive thresholds in BDL model within 8 days in our study is due to a specific change in pain transmission rather than a sign of lethargy or malaise.…”

Section: Discussionsupporting

confidence: 47%

Proteinase-activated Receptor 1 Contributed to Up-regulation of Enkephalin in Keratinocytes of Patients with Obstructive Jaundice

Tao

Chen

et al. 2014

Anesthesiology

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“…The data obtained in the present experiment agreed with those observed in rats exposed to the EPM. It has been shown that APO increases the time spent in the open arms of the maze via the dopamine D2 receptors (23,31). This also agrees with the claim that open-arm exploration in the EPM can be used as an index of impulsive behavior (32).…”

Section: Discussionmentioning

confidence: 99%

The elevated gradient of aversion: a new apparatus to study the rat behavior dimensions of anxiety, fear, and impulsivity

Rico

Bonuti

Morato

2019

Braz J Med Biol Res

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Few behavioral tests allow measuring several characteristics and most require training, complex analyses, and/or are time-consuming. We present an apparatus based on rat exploratory behavior. Composed of three different environments, it allows the assessment of more than one behavioral characteristic in a short 3-min session. Factorial analyses have defined three behavioral dimensions, which we named Exploration, Impulsivity, and Self-protection. Behaviors composing the Exploration factor were increased by chlordiazepoxide and apomorphine and decreased by pentylenetetrazole. Behaviors composing the Impulsivity factor were increased by chlordiazepoxide, apomorphine, and both acute and chronic imipramine treatments. Behaviors composing the Self-protection factor were decreased by apomorphine. We submitted Wistar rats to the open-field test, the elevated-plus maze, and to the apparatus we are proposing. Measures related to exploratory behavior in all three tests were correlated. Measures composing the factors Impulsivity and Self-protection did not correlate with any measures from the two standard tests. Also, compared with existing impulsivity tests, the one we proposed did not require previous learning, training, or sophisticated analysis. Exploration measures from our test are as easy to obtain as the ones from other standard tests. Thus, we have proposed an apparatus that measured three different behavioral characteristics, was simple and fast, did not require subjects to be submitted to previous learning or training, was sensitive to drug treatments, and did not require sophisticated data analyses.

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Effects of dopamine receptor agonist and antagonists on cholestasis-induced anxiolytic-like behaviors in rats

Cited by 21 publications

References 70 publications

Peripheral and spinal 5-HT receptors participate in cholestatic itch and antinociception induced by bile duct ligation in rats

Peripheral and spinal 5-HT receptors participate in cholestatic itch and antinociception induced by bile duct ligation in rats

Proteinase-activated Receptor 1 Contributed to Up-regulation of Enkephalin in Keratinocytes of Patients with Obstructive Jaundice

The elevated gradient of aversion: a new apparatus to study the rat behavior dimensions of anxiety, fear, and impulsivity

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