Effects of dopaminergic drugs on locomotor activity in teleost fish of the genus Oreochromis (Cichlidae): involvement of the telencephalon

Mok, E.Y.-M.; Munro, A.D.

doi:10.1016/s0031-9384(98)00038-9

Cited by 52 publications

(38 citation statements)

References 35 publications

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“…Furthermore, apomorphine inhibits aggression in A. pulcher in a dose-dependant fashion; this is consistent with observations for mammals treated with apomorphine (Munro, 1986). Investigations of apomorphine treatment on fish behaviour have also lead researchers to suggest that telencephalic dopaminergic neurons mediate fear responses of fish (Oreochromis niloticus, O. mossambicus) to novel environments (Mok and Munro, 1998). Meperidine derivative (MPTP) causes a Parkinsonian syndrome in humans and primates by altering or destroying mesostriatal dopaminergic neurons (Pollard et al, 1996).…”

Section: Dopaminergic Systemssupporting

confidence: 70%

“…Since the behavioural effects of ablation of the telencephalon in fish resemble results from lesion experiments on the mammalian limbic system (Portavella et al, 2002), the fish telencephalon, along with other brain structures, has been hypothesised to be functionally homologous to limbic structures found in tetrapods (Ohnishi, 1997;Mok and Munro, 1998). The limbic system of tetrapods may consist of the hippocampus, amygdala, hypothalamus, habenula and mammillary bodies (Kötter and Meyer, 1992).…”

Section: Limbic Systemmentioning

confidence: 99%

“…In addition, Santangelo et al (2001) showed that substance P improved learning and memory processes of goldfish during avoidance testing, and implicated ventral telencephalic structures in mediating such processes. In fish, dopaminergic agonists may influence behaviour (Mok and Munro, 1998), and have been implicated in mesolimbic regulation of aggression and fear. Munro (1986) showed that intercranial injections of d-amphetamine or immersion in apomorphine inhibited aggression in a teleost fish, Aequidens pulcher.…”

Section: Dopaminergic Systemsmentioning

confidence: 99%

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Can fish suffer?: perspectives on sentience, pain, fear and stress

Chandroo

Duncan

Moccia

2004

Applied Animal Behaviour Science

340

165

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In contrast to other major forms of livestock agriculture, there is a paucity of scientific information on the welfare of fish raised under intensive aquacultural conditions. This reflects an adherence to the belief that these animals have not evolved the salient biological characteristics that are hypothesised to permit sentience. In this review, we evaluate the scientific evidence for the existence of sentience in fish, and in particular, their ability to experience pain, fear and psychological stress. Teleost fish are considered to have marked differences in some aspects of brain structure and organization as compared to tetrapods, yet they simultaneously demonstrate functional similarities and a level of cognitive development suggestive of sentience. Anatomical, pharmacological and behavioural data suggest that affective states of pain, fear and stress are likely to be experienced by fish in similar ways as in tetrapods. This implies that fish have the capacity to suffer, and that welfare consideration for farmed fish should take these states into account. We suggest that the concept of animal welfare can be applied legitimately to fish. It is therefore appropriate to recognize and study the welfare of farmed fish.

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Section: Dopaminergic Systemssupporting

confidence: 70%

Section: Limbic Systemmentioning

confidence: 99%

Section: Dopaminergic Systemsmentioning

confidence: 99%

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Can fish suffer?: perspectives on sentience, pain, fear and stress

Chandroo

Duncan

Moccia

2004

Applied Animal Behaviour Science

340

165

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“…Although teleost fish lack midbrain dopamine sources, the ascending projection from the posterior tubercle to the ventral telencephalic area has been proposed to be analogous to the mammalian mesolimbic pathway (Rink and Wullimann, 2002). Moreover, as in mice, where augmentation of dopamine availability in the nucleus accumbens is sufficient to confer hyperlocomotive behavior (Heusner et al, 2003), the dopamine agonist apomorphine induces hyperlocomotion in adult goldfish (Mok and Munro, 1998). Likewise, we found that apomorphine strongly potentiates spontaneous swimming in 6 dpf zebrafish (data not shown), arguing that a mesolimbic-like circuit is already functional in these animals.…”

Section: Discussionmentioning

confidence: 99%

Sensorimotor Gating in Larval Zebrafish

Burgess

Granato²

2007

J. Neurosci.

466

671

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Control of behavior in the natural environment where sensory stimuli are abundant requires superfluous information to be ignored. In part, this is achieved through selective transmission, or gating of signals to motor systems. A quantitative and clinically important measure of sensorimotor gating is prepulse inhibition (PPI) of the startle response, impairments in which have been demonstrated in several neuropsychiatric disorders, including schizophrenia. Here, we show for the first time that the acoustic startle response in zebrafish larvae is modulated by weak prepulses in a manner similar to mammalian PPI. We demonstrate that, like in mammals, antipsychotic drugs can suppress disruptions in zebrafish PPI induced by dopamine agonists. Because genetic factors underlying PPI are not well understood, we performed a screen and isolated mutant lines with reduced PPI. Analysis of Ophelia mutants demonstrates that they have normal sensory acuity and startle performance, but reduced PPI, suggesting that Ophelia is critical for central processing of sensory information. Thus, our results provide the first evidence for sensorimotor gating in larval zebrafish and report on the first unbiased screen to identify genes regulating this process.

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“…More recent studies, based on neuro-anatomical evidence and behavioural expression suggest that like mammals, fish experience pain, fear and stress (Mok and Munro, 1998;Portavella et al, 2002;Sneddon, 2003;Chandroo et al, 2004). Consequently, studies addressing fish welfare at slaughter have started much later compared to land animals (Figure 1).…”

Section: Farmed Fishmentioning

confidence: 99%

Pre-slaughter conditions, animal stress and welfare: current status and possible future research

Terlouw

Arnould

Aupérin³

et al. 2008

Animal

169

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The present paper describes the main procedures used to slaughter fowl, pigs, calves and adult cattle, sheep, and farmed fish, starting on the farm and ending with the death of the animal at the abattoir. It reviews the currently known causes of stress, indicated by behavioural and physiological measurements on the animal level, and by post-mortem muscle metabolism. During the pre-slaughter period, psychological stress is due to changes of environment, social disturbances and handling, and physical stress is due to food deprivation, climatic conditions, fatigue, and sometimes pain. The exact causes of stress depend, however, on the characteristics of each species, including the rearing system. For fowl, bird catching and crating, duration and climatic conditions of transport and of lairage and shackling are the main known pre-slaughter stress factors. For pigs, stress is caused by fighting during mixing of pens, loading and unloading conditions, and introduction in the restrainer. Handling and novelty of the situation contribute to the stress reactions. For veal calves and adult cattle, disruption of the social group, handling, loading and sometimes unloading conditions, fatigue, novelty of the situation and for calves mixing with unfamiliar animals are known stress factors. Gathering and yarding of extensively reared lambs and sheep causes stress, particularly when shepherd dogs are used. Subsequent transport may induce fatigue, especially if sheep are commercialised through auctions or markets. In farmed fish, stress is predominantly related to environmental aspects such as temperature, oxygen, cleanliness of the water and, to a certain extent, stocking density and removal of the fish from the water. If transport and lairage conditions are good and their durations not too long, they may allow pigs, calves and adult cattle, sheep, and fish to rest. For certain species, it was shown that genetic origin and earlier experience influence reactions to the slaughter procedure. Stunning techniques used depend on the species. Pigs and fowl are mostly electrically or gas-stunned, while most adult cattle are stunned with a captive bolt pistol. Calves and sheep may be electrically stunned or with a captive bolt pistol. Various stunning methods exist for the different farmed fish species. Potential causes of stress associated with the different stunning procedures are discussed. The paper addresses further consequences for meat quality and possible itineraries for future research. For all species, and most urgently for fish, more knowledge is needed on stunning and killing techniques, including gas-stunning techniques, to protect welfare.

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Effects of dopaminergic drugs on locomotor activity in teleost fish of the genus Oreochromis (Cichlidae): involvement of the telencephalon

Cited by 52 publications

References 35 publications

Can fish suffer?: perspectives on sentience, pain, fear and stress

Can fish suffer?: perspectives on sentience, pain, fear and stress

Sensorimotor Gating in Larval Zebrafish

Pre-slaughter conditions, animal stress and welfare: current status and possible future research

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