Effects of dopaminergic therapy on locomotor adaptation and adaptive learning in persons with Parkinson's disease

Roemmich, Ryan T.; Hack, Nawaz; Akbar, Umer; Hass, Chris J.

doi:10.1016/j.bbr.2014.03.041

Cited by 43 publications

(46 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Second, people with PD completed all data collection ON levodopa. Previous studies have indicated that levodopa may have positive [38], or perhaps negative [25] effects on learning depending on the type learning evaluated (i.e. explicit, implicit, upper or lower limb, etc.).…”

Section: Discussionmentioning

confidence: 99%

Postural motor learning in people with Parkinson’s disease

2016

View full text Add to dashboard Cite

Protective postural responses to external perturbations are hypokinetic in people with Parkinson’s disease (PD) and improving these responses may reduce falls. However, the ability of people with PD to improve postural responses with practice is poorly understood. Our objective was to determine whether people with PD can improve protective postural responses similarly to healthy adults through repeated perturbations, and whether improvements are retained or generalize to untrained perturbations. Twelve healthy adults and 15 people with PD underwent 25 forward and 25 backward translations of the support surface, eliciting backward and forward protective steps, respectively. We assessed whether: 1) performance improved over one day of practice, 2) changes were retained 24 hours later, and 3) improvements generalized to untrained (lateral) postural responses. People with PD and healthy adults improved postural response characteristics including center of mass displacement after perturbations (p<0.001), margin of stability at first foot-fall (p=0.001), step latency (p=0.044), and number of steps (p=0.001). However, unlike controls, improvements in people with PD occurred primarily in the first block of trials. Improvements were more pronounced during backward protective stepping than forward, and with the exception of step latency, were retained 24 hours later. Improvements in forward-backward stepping did not generalize to lateral protective stepping. People with PD can improve protective stepping over the course of one day of perturbation practice. Improvements were generally similar to healthy adults, and were retained in both groups. Perturbation practice may represent a promising approach to improving protective postural responses in people with PD, however additional research is needed to understand how to enhance generalization.

show abstract

Section: Discussionmentioning

confidence: 99%

Postural motor learning in people with Parkinson’s disease

2016

View full text Add to dashboard Cite

show abstract

“…In individuals with Parkinson's disease, re-learning (savings) of an upper extremity movement is attenuated (Marinelli et al 2009;Bédard and Sanes 2011), similar to the young children in this study. However, savings of split-belt walking was recently found to be intact in Parkinson's disease (Roemmich et al 2014). New studies are needed to understand which brain networks are most important for development of mature re-learning patterns.…”

Section: Protracted Brain Development May Explain Attenuated Re-learnmentioning

confidence: 99%

Motor learning in childhood reveals distinct mechanisms for memory retention and re-learning

et al. 2016

Self Cite

View full text Add to dashboard Cite

Adults can easily learn and access multiple versions of the same motor skill adapted for different conditions (e.g., walking in water, sand, snow). Following even a single session of adaptation, adults exhibit clear day-to-day retention and faster re-learning of the adapted pattern. Here, we studied the retention and re-learning of an adapted walking pattern in children aged 6-17 yr. We found that all children, regardless of age, showed adult-like patterns of retention of the adapted walking pattern. In contrast, children under 12 yr of age did not re-learn faster on the next day after washout had occurred-they behaved as if they had never adapted their walking before. Re-learning could be improved in younger children when the adaptation time on day 1 was increased to allow more practice at the plateau of the adapted pattern, but never to adult-like levels. These results show that the ability to store a separate, adapted version of the same general motor pattern does not fully develop until adolescence, and furthermore, that the mechanisms underlying the retention and rapid re-learning of adapted motor patterns are distinct.

show abstract

“…Over several minutes of split-belt walking, interlimb parameters such as step length symmetry and double support time adapt (Reisman et al, 2005). Step length symmetry adaptation is a robust finding replicated in stroke survivors (Reisman et al 2007; Reisman et al 2013), Parkinson’s disease patients (Roemmich et al 2014a; Roemmich et al 2014b), and many conditions in healthy subjects (Malone, Bastian, 2010; Torres-Oviedo, Bastian, 2012; Torres-Oviedo, Bastian, 2010; Finley et al, 2014). During split-belt walking, ground reaction forces (GRF) exhibit predictive changes at initial contact, although vertical GRF in single support and propulsive GRF changes immediately, indicating reactive control (Mawase et al, 2013; Ogawa et al, 2014).…”

Section: Introductionmentioning

confidence: 97%

“…However, changes in joint work during split-belt adaptation are largely unknown. Only ankle work in late stance and hip work in swing have been quantified in split-belt adaptation (Roemmich et al 2014a, Hinkel-Lipsker, Hahn, 2016). Furthermore, split-belt walking has not been tested on trans-tibial amputees.…”

Section: Introductionmentioning

confidence: 99%

Two biomechanical strategies for locomotor adaptation to split-belt treadmill walking in subjects with and without transtibial amputation

Selgrade

Toney

Chang

2017

Journal of Biomechanics

View full text Add to dashboard Cite

Locomotor adaptation is commonly studied using split-belt treadmill walking, in which each foot is placed on a belt moving at a different speed. As subjects adapt to split-belt walking, they reduce metabolic power, but the biomechanical mechanism behind this improved efficiency is unknown. Analyzing mechanical work performed by the legs and joints during split-belt adaptation could reveal this mechanism. Because ankle work in the step-to-step transition is more efficient than hip work, we hypothesized that control subjects would reduce hip work on the fast belt and increase ankle work during the step-to-step transition as they adapted. We further hypothesized that subjects with unilateral, trans-tibial amputation would instead increase propulsive work from their intact leg on the slow belt. Control subjects reduced hip work and shifted more ankle work to the step-to-step transition, supporting our hypothesis. Contrary to our second hypothesis, intact leg work, ankle work and hip work in amputees were unchanged during adaptation. Furthermore, all subjects increased collisional energy loss on the fast belt, but did not increase propulsive work. This was possible because subjects moved further backward during fast leg single support in late adaptation than in early adaptation, compensating by reducing backward movement in slow leg single support. In summary, subjects used two strategies to improve mechanical efficiency in split-belt walking adaptation: a CoM displacement strategy that allows for less forward propulsion on the fast belt; and, an ankle timing strategy that allows efficient ankle work in the step-to-step transition to increase while reducing inefficient hip work.

show abstract

Effects of dopaminergic therapy on locomotor adaptation and adaptive learning in persons with Parkinson's disease

Cited by 43 publications

References 45 publications

Postural motor learning in people with Parkinson’s disease

Postural motor learning in people with Parkinson’s disease

Motor learning in childhood reveals distinct mechanisms for memory retention and re-learning

Two biomechanical strategies for locomotor adaptation to split-belt treadmill walking in subjects with and without transtibial amputation

Contact Info

Product

Resources

About