1997
DOI: 10.1097/00000539-199705000-00002
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Effects of Dopexamine on Creatinine Clearance, Systemic Inflammation, and Splanchnic Oxygenation in Patients Undergoing Coronary Artery Bypass Grafting

Abstract: Impairment of splanchnic and peripheral tissue perfusion during cardiopulmonary bypass (CPB) may be responsible for endotoxin-mediated systemic inflammation and acute phase responses. We examined the effects of dopexamine on hemodynamic parameters, creatinine clearance, systemic and splanchnic oxygenation, gastric mucosal pH (pHi), and mixed and hepatic venous plasma levels of endotoxin, interleukin-6 (IL-6), serum amyloid A (SAA), and C-reactive protein (CRP) in 44 patients scheduled for coronary artery bypas… Show more

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Cited by 37 publications
(8 citation statements)
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“…These patients may benefit from implementation of greater renal protective measures during CPB (discontinuation of nephrotoxic antibiotics and use of mannitol, loop diuretics, and low-dose dopamine) with closer monitoring of renal function afterwards. 11 16…”
Section: Discussionmentioning
confidence: 99%
“…These patients may benefit from implementation of greater renal protective measures during CPB (discontinuation of nephrotoxic antibiotics and use of mannitol, loop diuretics, and low-dose dopamine) with closer monitoring of renal function afterwards. 11 16…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies have attributed the fall of pHi in cardiac surgical patients to splanchnic hypoperfusion during CPB, as demonstrated by a decrease in the hepatic venous haemoglobin saturation (14) or in the hepatic venous blood flow (15). However, other studies have also shown that this decrease in pHi is not necessarily associated with a decrease in the hepatic venous haemoglobin saturation (24, 33). Therefore, a decrease in pHi seems to reflect a reduction in the regional intramucosal perfusion rather than that in the global splanchnic blood flow (34).…”
Section: Discussionmentioning
confidence: 94%
“…1). A total of 70 studies (5,554 patients) met eligibility criteria [17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86] (table 1). …”
Section: Resultsmentioning
confidence: 99%