Effects of dorsal striatum lesions in tone fear conditioning and contextual fear conditioning

Ferreira, Tatiana Lima; Moreira, Karin M.; Ikeda, Daniela C.; Bueno, Orlando Francisco Amodeo; Oliveira, Maria Gabriela Menezes

doi:10.1016/s0006-8993(03)03217-7

Cited by 50 publications

(32 citation statements)

References 37 publications

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“…This pattern of responding suggests that while the dlCPu drives drug seeking (likely via stimulus-response learning), intact dlCPu function may not be necessary for the processing of contextual information of the relapse event (as evidenced by the subsequent test trial data showing that extinction learning had occurred). This possibility is supported by prior research indicating that dorsal striatal lesions failed to affect contextual fear conditioning (Ferreira et al 2003). In contrast, inactivation of the NAcore and NAshell failed to affect drug seeking on the initial test day.…”

Section: Discussionsupporting

confidence: 52%

The role of dorsal vs ventral striatal pathways in cocaine-seeking behavior after prolonged abstinence in rats

2007

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The dorsal but not ventral striatum plays a critical role in cocaine seeking immediately after abstinence. These data support the theory that chronic cocaine may shift activity from the ventral to dorsal striatum during drug seeking under certain conditions. While not necessary at the time of relapse, the ventral striatum appears to be involved in processing critical information of the relapse event.

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Section: Discussionsupporting

confidence: 52%

The role of dorsal vs ventral striatal pathways in cocaine-seeking behavior after prolonged abstinence in rats

2007

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“…When returned to the same chamber in the absence of the aversive stimulus, the animal presents a permanent fear reaction to contextual cues previously associated with the footshock. Considerable evidence from animal and human experiments indicate that fear conditioning in response to a discrete CS and contextual cues is mediated by different neural circuitries (Indovina et al, 2011;Ferreira et al, 2003;Kim & Fanselow, 1992;LeDoux, 2000;Pohlack et al, 2011). These results support the hypothesis of at least two dimensions of fear conditioning, and each dimension might be related to clinically distinct anxiety disorders.…”

Section: Contextual Fear Conditioning As a Model Of Generalized Anxiesupporting

confidence: 56%

The Carioca High and Low Conditioned Freezing Lines: A New Animal Model of Generalized Anxiety Disorder

Gomes¹,

Silva²,

Landeira-Fernández³

2011

Anxiety Disorders

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“…The tasks were performed according to Ferreira et al (2003) with some modifications. These two tasks also comprised two sessions, the acquisition training and the retention test.…”

Section: Contextual Fear Conditioning Task (Cfc) and Tone Fear Con-dimentioning

confidence: 99%

Oxidative Stress Induced by Intense and Exhaustive Exercise Impairs Murine Cognitive Function

Rosa¹,

Takahashi²,

Aboulafia³

et al. 2007

Journal of Neurophysiology

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Rosa EF, Takahashi S, Aboulafia J, Nouailhetas VL, Oliveira MG. Oxidative stress induced by intense and exhaustive exercise impairs murine cognitive function. J Neurophysiol 98: 1820 -1826, 2007. First published July 11, 2007 doi:10.1152/jn.01158.2006. It has been shown that exercise is helpful against brain disorders. However, this may not be true for intense exercise (IE). Because it is easy to misadjust exercise intensity with physical condition, it is essential to know the effects of IE on cognitive process because it may have important consequences on people skills and work skills. We investigated the effects of IE on male C57Bl/6 mice, 3-mo-old, undergoing 10 days of intense and exhaustive running program on cognition and its possible relationship with brain oxidative stress. Cognition was evaluated by three different cognitive tests: passive avoidance task, contextual fear conditioning, and tone fear conditioning, performed 24 h after the last exercise session. Brain oxidative stress was evaluated by lipid peroxidation and protein oxidation. There was a remarkable memory reduction of exercised animals in comparison with the control group, associated with increase in the brain oxidative stress, with no alterations in shock sensitivity, locomotion and anxiety parameters. Concurrent vitamin C and E supplementation fully prevented the memory decrement induced by IE and partially recovered both the increased the brain lipid peroxidation and the protein oxidation. In conclusion, IE-induces a high index of brain oxidative stress and impairs memory in murine model that was prevented by vitamin C and E supplementation.

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Effects of dorsal striatum lesions in tone fear conditioning and contextual fear conditioning

Cited by 50 publications

References 37 publications

The role of dorsal vs ventral striatal pathways in cocaine-seeking behavior after prolonged abstinence in rats

The role of dorsal vs ventral striatal pathways in cocaine-seeking behavior after prolonged abstinence in rats

The Carioca High and Low Conditioned Freezing Lines: A New Animal Model of Generalized Anxiety Disorder

Oxidative Stress Induced by Intense and Exhaustive Exercise Impairs Murine Cognitive Function

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