Effects of drinking diesel-contaminated water on the hematological and serum biochemical parameters of mice

Udem, Samuel Chukwuneke; Lekwuwa, Isaac A. M.; Udem, Ngozi Dorathy

doi:10.1007/s00580-009-0945-1

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…Iheoliaha et al (2009) reported that female albino rats given water contaminated with 5% engine oil for a period of 21 days had a significant increase in the activity of the ALP serum enzyme. The mice that were allowed to drink water contaminated with diesel 1% (V/V) for 6 weeks had a significant increase in activities of ALP, ASP and ALT serum enzymes (Udem et al 2009). Rat exposure to gasoline vapor for 6hr/day, 5 days/ week for 20 weeks caused a significant increase in the activity of the ALP, ALT and AST serums (Uboh et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Hepatotoxicity of Gasoline as an Environmental Pollutant on Albino Mice

El-Ghazaly¹,

Ali²,

Dekinesh³

et al. 2015

AJS

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This study focuses on finding if the hazards produced by gasoline 90 (vehicle fuel in Egypt) are less than those produced by gasoline 80 in healthy Swiss albino mice. Sixty mice were equally divided into 3 groups: group one (control), group two (topically treated with 0.5ml gasoline 90 /kg B.W.) and group three (topically treated with 0.5ml gasoline 80 /kg B.W.). The specimens were taken after 4 and 8 weeks. Determination of bioaccumulation of some heavy metals, biochemical examination and a light microscopical study were performed. It was found that the accumulation of lead, cadmium and nickel in the liver had the following order lead > cadmium > nickel. After topically treated with gasoline 90 and 80 for 8 weeks, there was an increase in the activities of the serum liver function enzymes (alkaline phosphatase, alanine aminotransferase and aspartate amino transferase) and adenosine deaminase and a decrease in the total protein content of the liver homogenate. There were pathological changes which were more pronounced by treatment with gasoline 80 than with gasoline 90 depending upon treatment duration from 4 to 8 weeks. After 4 weeks of topically treating mice with gasoline 90, cellular infiltration, dilatation of blood sinusoid and cytoplasmic vaculation were demonstrated. After 8 weeks the liver architecture of the mice was disrupted with liquid infiltration and the presence of foamy areas. After 4 weeks of topically treating mice with gasoline 80, we observed a shrinking of the blood sinusoid, hypatocyte vaculation with pyknotic nuclei and different stages of karyolysis. After 8 weeks, there was a noticeable hypatocyte degeneration and complete disappearance of blood sinusoids in the liver sections of the mice.

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Section: Discussionmentioning

confidence: 99%

Hepatotoxicity of Gasoline as an Environmental Pollutant on Albino Mice

El-Ghazaly¹,

Ali²,

Dekinesh³

et al. 2015

AJS

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“…Also, several studies have reported that petroleum and its products have the ability to increase the level of liver marker enzymes [8][9][10]. Vitamin A, vitamin C, vitamin E and selenium are among nutrients with antioxidant activity.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Vitamins C and E against Gasoline Vapors Induced Haematological and Biochemical Changes in Male Rats

Sedky¹

2015

J. Sci. Res.

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The present work was designed to investigate the changes in some hematological, biochemical parameters and lipid profile as well as possible protective role of vitamins C and E against gasoline vapors induced toxicity in male rats. The present results showed that gasoline 80 vapors significantly decreased (p≤0.05) the concentration of total serum protein (TSP) and albumin concentrations and increased (p≤0.05) in serum activities of serum aminotransferases (ALT and AST) and alkaline phosphatase (ALP) compared to the control group. Also, exposure to gasoline 80 vapors induced significant decrease (p≤0.05) in hemoglobin concentration, red blood cell count (RBCs), packed cell volume (PCV) and high density lipoprotein cholesterol (HDL-C) compared to control group. On the other hand, exposure to gasoline 80 vapors resulted in significant increase (p≤0.05) in the levels of total cholesterol (TC), triglycerides (TGs), LDLcholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C) relative to untreated experimental animals. However, concomitant treatment with gasoline vapors and administration of vitamins C and E exhibited a protective role on the observed toxic effect of gasoline vapors in male rats. The results of the present study indicated that toxic effects of gasoline vapors could be reduced by dietary supplementation of vitamins C and E.

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Effects of drinking diesel-contaminated water on the hematological and serum biochemical parameters of mice

Cited by 2 publications

References 14 publications

Hepatotoxicity of Gasoline as an Environmental Pollutant on Albino Mice

Hepatotoxicity of Gasoline as an Environmental Pollutant on Albino Mice

Protective Effect of Vitamins C and E against Gasoline Vapors Induced Haematological and Biochemical Changes in Male Rats

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