Effects of Drug-Free Pectin Hydrogel Films on Thermal Burn Wounds in Streptozotocin-Induced Diabetic Rats

Nordin, Nur Nadhirah; Aziz, Nur Karimah; Naharudin, Idanawati; Anuar, Nor Khaizan

doi:10.3390/polym14142873

Cited by 14 publications

(6 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These properties, along with the non-toxicity, biodegradability and biocompatibility, make pectin-based materials adequate for a wide range of applications such as agriculture, pharmacy, food and biomedicine. Up to date, pectin-based three-dimensional networks have been investigated for tissue engineering [ 10 ], drug delivery [ 11 ], wound healing [ 12 , 13 ], food technology [ 14 ] and as food packaging material [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Crosslinking on the Characteristics of Pectin Monolith Cryogels

et al. 2022

View full text Add to dashboard Cite

In this research, the pectin monoliths were prepared via the sol-gel process through different routes of crosslinking and additional freeze-drying. The crosslinking reaction was induced by the use of calcium ions in aqueous solutions and in alcohol/water solutions. The resulting pectin monoliths obtained by freeze-drying were macroporous with open cells, limited specific surface area, moderate mechanical stability and moderate biodegradation rate. The presence of alcohol in crosslinking solution significantly changed the morphology of final pectin monoliths, which was evidenced by the reduction of their pore size for one order. The specific surface area of pectin monoliths obtained through the calcium-water-alcohol route was 25.7 m2/g, the Young compressive modulus was 0.52 MPa, and the biodegradation rate was 45% after 30 days of immersion in compost media. Considering that pectin can be obtained from food waste, and its physical properties could be tailored by different crosslinking routes, the pectin monoliths could find wide application in the pharmaceutical, agricultural, medical and food industries, providing sustainable development concepts.

show abstract

Section: Introductionmentioning

confidence: 99%

Impact of Crosslinking on the Characteristics of Pectin Monolith Cryogels

et al. 2022

View full text Add to dashboard Cite

show abstract

“…PL and PC were chosen because of the known biodegradability, biocompatibility and proven role in tissue repair [20][21][22][26][27][28]. However, optimization of the concentration of these two components, particularly of PC is crucial.…”

Section: Preparation and Characterization Of The Pfmentioning

confidence: 99%

“…Among the biopolymers that are compatible with PL, pectin (PC) holds good promise to develop a PF. PC is also a biodegradable, biocompatible molecule and possesses antimicrobial property [26][27][28]. Although, a PF based on PC will be endowed with intrinsic antimicrobial capability, the magnitude of the antimicrobial action and bioburden reduction achievable can be limited [29].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antimicrobial photodynamic action of a pluronic and pectin based film loaded with methylene blue against methicillin resistant Staphylococcus aureus

Chakraborty,

Shukla,

Rastogi

et al. 2024

Biomed. Mater.

View full text Add to dashboard Cite

Antimicrobial wound dressings play a crucial role in treatment of wound infections. However, existing commercial options fall short due to antibiotic resistance and the limited spectrum of activity of newly emerging antimicrobials against bacteria that are frequently encountered in wound infections. Antimicrobial photodynamic therapy (aPDT) is very promising alternative therapeutic approach against antibiotic resistant microbes such as methicillin resistant Staphylococcus aureus (MRSA). However, delivery of the photosensitizer (PS) homogeneously to the wound site is a challenge. Though polymeric wound dressings based on synthetic and biopolymers are being explored for aPDT, there is paucity of data regarding their in vivo efficacy. Moreover, there are no studies on use of PS loaded, pluoronic (PL) and pectin (PC) based films for aPDT. We report development of a polymeric film for potential use in aPDT. The film was prepared using PL and PC via solvent casting approach and impregnated with Methylene blue (MB) for photodynamic inactivation of MRSA in vitro and in vivo. AFM imaging of the films yielded vivid pictures of surface topography, with rough surfaces, pores, and furrows. The PL:PC ratio (2:3) was optimized that would result in an intact film but exhibit rapid release of MB in time scale suitable for aPDT. The film showed good antibacterial activity against planktonic suspension, biofilm of MRSA upon exposure to red light. Investigations on MRSA infected excisional wounds of mice reveal that topical application of MB loaded film for 30 min followed by red light exposure for 5 min (fluence; ~30 J/cm2) or 10 min (fluence; ~60 J/cm2) reduces ~80 or ∼92% of bioburden, respectively. Importantly, the film elicits no significant cytotoxicity against keratinocytes and human adipose derived mesenchymal stem cells. Taken together, our data demonstrate that PS-loaded PL-PC based films are a promising new tool for treatment of MRSA infected wounds.

show abstract

“…Pectins are inexpensive and non-toxic, which makes them ideal for use in the creation of medicinal formulations [66]. Chemical structure of pectin represented in Figure 5 [67].…”

Section: Pectinmentioning

confidence: 99%

Mukoadezi̇f Poli̇merleri̇n Kolon Hedefli̇ İlaç Taşiyici Si̇stemlerde Kullanimi: Detayli Bi̇r İnceleme

DELJAVAN GHODRATI,

ÇOMOĞLU

2024

Ankara Ecz. Fak. Derg.

View full text Add to dashboard Cite

Objective: Mucoadhesive polymers have emerged as crucial components in the realm of drug delivery systems, particularly in the context of targeted treatments within the colon. These polymers possess adhesive properties that enable them to form temporary bonds with mucosal surfaces, extending the contact time of drugs with the colonic mucosa. This review provides a comprehensive overview of mucoadhesive polymers for colon drug delivery systems. Natural polymers such as chitosan and alginate, along with synthetic counterparts like polyacrylic acid derivatives, find application in these systems. The advantages of mucoadhesive polymers lie in their ability to facilitate site-specific drug delivery, thereby minimizing systemic side effects, and in enabling controlled and sustained release of drugs for improved bioavailability. Despite these benefits, challenges including variability in mucosal conditions and the imperative need for biocompatibility must be addressed. The applications of mucoadhesive polymers span diverse medical conditions, including targeted delivery of anti-inflammatory drugs for inflammatory bowel diseases, localized administration of chemotherapeutic agents for colon cancer treatment, and precise delivery of antibiotics for colonic infections. Result and Discussion: As a promising avenue for optimizing colon drug delivery, mucoadhesive polymers offer great potential for the development of effective and well-tolerated treatments for various colonic disorders.

show abstract

Effects of Drug-Free Pectin Hydrogel Films on Thermal Burn Wounds in Streptozotocin-Induced Diabetic Rats

Cited by 14 publications

References 34 publications

Impact of Crosslinking on the Characteristics of Pectin Monolith Cryogels

Impact of Crosslinking on the Characteristics of Pectin Monolith Cryogels

Evaluation of antimicrobial photodynamic action of a pluronic and pectin based film loaded with methylene blue against methicillin resistant Staphylococcus aureus

Mukoadezi̇f Poli̇merleri̇n Kolon Hedefli̇ İlaç Taşiyici Si̇stemlerde Kullanimi: Detayli Bi̇r İnceleme

Contact Info

Product

Resources

About