Effects of drugs on secondary epileptogenic lesions

Morrell, Frank; Baker, Lowell L.

doi:10.1212/wnl.11.8.651

Cited by 40 publications

(21 citation statements)

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“…Later both hippocampi showed synchronous spiking. This tendency for activa tion of the hippocampus, both unilaterally and bilaterally has been docu mented previously [9,17,[28][29][30].…”

Section: Commentsupporting

confidence: 56%

Evolution of Seizure Patterns in Experimental Epilepsy

Levin¹,

Wyss²,

Scollo-Lavizzari³

et al. 1968

Eur Neurol

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“…Later both hippocampi showed synchronous spiking. This tendency for activa tion of the hippocampus, both unilaterally and bilaterally has been docu mented previously [9,17,[28][29][30].…”

Section: Commentsupporting

confidence: 56%

Evolution of Seizure Patterns in Experimental Epilepsy

Levin¹,

Wyss²,

Scollo-Lavizzari³

et al. 1968

Eur Neurol

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“…A positive effect of surgery on preoperative epilepsy has been reported I~ but the appearance of purely postoperative seizures was pointed out in various reviews 1 ' 3-s, 18, 19 Another yet undefined topic concerns the usefulness of anti-epileptic drugs (AEDs) in preventing postoperative seizures, particularly in patients who did not have preoperative fits. In fact, rational elements supporting the value of a prophylaxis may be suggested from different clinical patterns such as post-traumatic epilepsies 16, 26 and from experimental evidence 15,20,[23][24][25], but data concerning the effects of prophylaxis in patients operated on for cerebral neoplasms are controversial 7, 12,13,17 The aim of our study was to define the pattern of occurrence and the risk factors for postoperative seizures in patients operated'on for supratentorial neoplasms, with or without preoperative seizures, and to test the value of a preventive treatment with two different AEDs (phenobarbital and phenytoin).…”

Section: Introductionmentioning

confidence: 99%

Influence of surgery and antiepileptic drugs on seizures symptomatic of cerebral tumours

et al. 1990

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One hundred and twenty-eight adult patients presenting with and operated on for supratentorial neoplasms were studied. Sixty-five had preoperative seizures and were treated with antiepileptic drugs (AEDs). Among the 63 patients without preoperative epileptic fits, 41 were given AEDs (either phenobarbital or phenytoin) as prophylactic treatment and 22 were not treated. The preoperative epilepsy course was considered with respect to tumour site and histological type. Early and late postoperative seizure occurrence was considered in the different groups of patients. The results suggest the usefulness of a short term preventive treatment with AEDs after surgery in patients without preoperative seizures. In patients with preoperative epilepsy, AEDs should be continued after surgery. However long-term AEDs treatment should not be recommended in patients without preoperative epilepsy. In fact, no significant difference in late seizure occurrence was found between preventively treated and untreated patients.

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“…Approaches that exemplify these principles are the longitudinal design of the comparative evaluation of combined EEG and MRI as biomarkers of specific epilepsy outcomes in the FEBSTAT study [12], the demonstration in pre-clinical studies that selective neuroprotection of the entorhinal and piriform cortex, but not of the hippocampus, was capable of delaying epileptogenesis [35], as well as the preclinical evidence for neuroprotective effects of phenobarbital [68,69]. Yet, validation of biomarkers with these long-term longitudinal studies will be particularly time-consuming, as well as expensive.…”

Section: What Are the Challenges?mentioning

confidence: 99%

In Search of Epilepsy Biomarkers in the Immature Brain: Goals, Challenges and Strategies

Galanopoulou¹,

Moshé

2011

Biomarkers Med.

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Epilepsy and seizures are very common in the early years of life and are often associated with significant morbidity and mortality. Identification of biomarkers for the early detection of epileptogenicity, epileptogenesis, comorbidities, disease progression and treatment implementation will be very important in implementing more effective therapies. This article summarizes the current needs in the search for new early life epilepsy-related biomarkers and discusses the candidate biomarkers that are under investigation, as well as the challenges associated with the identification and validation of these biomarkers.

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Effects of drugs on secondary epileptogenic lesions

Cited by 40 publications

References 0 publications

Evolution of Seizure Patterns in Experimental Epilepsy

Evolution of Seizure Patterns in Experimental Epilepsy

Influence of surgery and antiepileptic drugs on seizures symptomatic of cerebral tumours

In Search of Epilepsy Biomarkers in the Immature Brain: Goals, Challenges and Strategies

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