“…9,15 Clonidine has been found to be associated with improved walking ability in individuals with incomplete SCI (eg, longer cycles, increased treadmill speed, and more upright posture). 21,50 Tizanidine Tizanidine is an imidazole derivative and, like clonidine, is a centrally acting (spinally and supraspinally) alpha-2-adrenergic agonist. 9,10,13,34,48 Therefore, it acts by inhibiting the release of excitatory amino acids from the presynaptic terminals of excitatory spinal neurons.…”