Effects of Early Alcohol Exposure on Functional Organization and Microstructure of a Visual‐Tactile Integrative Circuit

Tang, Shiyu; Xu, Su; Gullapalli, Rao P.; Medina, Alexandre E.

doi:10.1111/acer.13611

Cited by 10 publications

(7 citation statements)

References 56 publications

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“…At this developmental time, alcohol greatly enhances the apoptosis that naturally occur in the cortex, leading to a reduction of the neuronal population that is more evident in inhibitory neurons (Ikonomidou et al, 2000; Smiley et al, 2015). In addition, alcohol during this period also leads to persistent deficits on neuronal plasticity (Medina et al, 2003; Puglia & Valenzuela, 2010; Rema & Ebner, 1999), which can affect refinement of neuronal circuits (Lebel et al, 2012; Medina et al, 2005; Tang et al, 2018) and potentially affect MSI.…”

Section: Discussionmentioning

confidence: 99%

Effects of developmental alcohol exposure on cortical multisensory integration

Keum

Pultorak

Meredith

et al. 2023

Eur J of Neuroscience

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Fetal alcohol spectrum disorder (FASD) is one of the most common causes of mental disabilities in the world with a prevalence of 1%-6% of all births. Sensory processing deficits and cognitive problems are a major feature in this condition. Because developmental alcohol exposure can impair neuronal plasticity, and neuronal plasticity is crucial for the establishment of neuronal circuits in sensory areas, we predicted that exposure to alcohol during the third trimester equivalent of human gestation would disrupt the development of multisensory integration (MSI) in the rostral portion of the posterior parietal cortex (PPr), an integrative visual-tactile area. We conducted in vivo electrophysiology in 17 ferrets from four groups (saline/alcohol; infancy/adolescence). A total of 1157 neurons were recorded after visual, tactile and combined visual-tactile stimulation. A multisensory (MS) enhancement or suppression is characterized by a significantly increased or decreased number of elicited spikes after combined visual-tactile stimulation compared to the strongest unimodal (visual or tactile) response. At the neuronal level, those in infant animals were more prone to show MS suppression whereas adolescents were more prone to show MS enhancement. Although alcohol-treated animals showed similar developmental changes between infancy and adolescence, they always 'lagged behind' controls showing more MS suppression and less enhancement. Our findings suggest that alcohol exposure during the last months of human gestation would stunt the development of MSI, which could underlie sensory problems seen in FASD.

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Section: Discussionmentioning

confidence: 99%

Effects of developmental alcohol exposure on cortical multisensory integration

Keum

Pultorak

Meredith

et al. 2023

Eur J of Neuroscience

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“…A primary objective for generating this animal model of FASD was to facilitate the development of neuroimaging biomarkers of abnormal brain development that arise from exposure to ethanol early in gestation, and that can be measured in human subjects. Several animal models of FASD have previously utilized MRI to characterize the effect of fetal alcohol exposure on early brain development (Astley et al, 1995, Leigland et al, 2013b, Parnell et al, 2009, Parnell et al, 2013, Parnell et al, 2014, Tang et al, 2018 and see (O'Leary-Moore et al, 2010, Wang andKroenke, 2015) for review. However, these studies primarily focused on rodents, which are born at earlier stages of CNS development than humans.…”

Section: Discussionmentioning

confidence: 99%

Detecting Neurodevelopmental Effects of Early‐Gestation Ethanol Exposure: A Nonhuman Primate Model of Ethanol Drinking During Pregnancy

Jiménez

Wang

Newman

et al. 2019

Alcoholism Clin & Exp Res

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Introduction: Gestational ethanol exposure is associated with multiple developmental abnormalities, collectively termed fetal alcohol spectrum disorder (FASD). While the majority of women abstain from ethanol following knowledge of pregnancy, one contributing factor to the high FASD prevalence is that pregnancy is not detected until 4-6 weeks. Thus, ethanol consumption continues during the initial stages of fetal development. Methods: An experimental protocol is described in which rhesus macaques self-administer 1.5 g/kg/day ethanol (or isocaloric maltose-dextrin) prior to pregnancy and through the first 60 days of a 168-day gestation term. Menstrual cycles were monitored, including measurements of circulating estradiol and progesterone levels. The latency to consume 1.5g/kg ethanol and blood ethanol concentration (BEC) were measured. Results: Twenty-eight fetuses (14 ethanol, 14 controls) were generated in this study. Ethanol did not affect menstrual cycles, or the probability of successful breeding. No ethanol-induced gross adverse effects on pregnancy were observed. Individual variability in latency to complete drinking translated into variability in BEC, measured 90 minutes following session start. Drinking latencies in controls and ethanol-drinkers were longer in the second gestational month than in the first. All pregnancies reached the planned experimental time point of G85, G110, or G135, when in utero MRIs were performed, fetuses were delivered by cesarean section, and brains were evaluated with ex vivo procedures, including slice electrophysiology. Fetal tissues have been deposited to the Monkey Alcohol Tissue Research Resource (MATRR). Conclusion: This FASD model takes advantage of the similarities between humans and rhesus macaques in gestational length relative to brain development, as well as similarities in ethanol self-*

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“…All the studies were performed on rats, except for one study that used ferrets (Tang et al, 2018). Different studies employed different protocols to deliver various doses of alcohol, some of which were aiming at inducing chronic alcohol consumption (Vetreno et al, 2016, Luo et al, 2017, while the others were mimicking the binge drinking cases (Pfefferbaum et al, 2015).…”

Section: Neurodegenerative Diseasesmentioning

confidence: 99%

“…Different studies employed different protocols to deliver various doses of alcohol, some of which were aiming at inducing chronic alcohol consumption (Vetreno et al, 2016, Luo et al, 2017, while the others were mimicking the binge drinking cases (Pfefferbaum et al, 2015). As was the case in ASD, all the studies aside from one (Tang et al, 2018) incorporated only male rats in their investigation.…”

Section: Neurodegenerative Diseasesmentioning

confidence: 99%

Diffusion-weighted MRI in neurodegenerative and psychiatric animal models: Experimental strategies and main outcomes

Eed

Cerdá

Lerma

et al. 2020

Journal of Neuroscience Methods

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Preclinical MRI approaches constitute a key tool to study a wide variety of neurological and psychiatric illnesses, allowing a more direct investigation of the disorder substrate and, at the same time, the possibility of backtranslating such findings to human subjects. However, the lack of consensus on the optimal experimental scheme used to acquire the data has led to relatively high heterogeneity in the choice of protocols, which can potentially impact the comparison between results obtained by different groups, even using the same animal model. This is especially true for diffusion-weighted MRI data, where certain experimental choices can impact not only on the accuracy and precision of the extracted biomarkers, but also on their biological meaning. With this in mind, we extensively examined preclinical imaging studies that used diffusion-weighted MRI to investigate neurodegenerative, neurodevelopmental and psychiatric disorders in rodent models. In this review, we discuss the main findings for each preclinical model, with a special focus on the analysis and comparison of the different acquisition strategies used across studies and their impact on the heterogeneity of the findings.

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Effects of Early Alcohol Exposure on Functional Organization and Microstructure of a Visual‐Tactile Integrative Circuit

Cited by 10 publications

References 56 publications

Effects of developmental alcohol exposure on cortical multisensory integration

Effects of developmental alcohol exposure on cortical multisensory integration

Detecting Neurodevelopmental Effects of Early‐Gestation Ethanol Exposure: A Nonhuman Primate Model of Ethanol Drinking During Pregnancy

Diffusion-weighted MRI in neurodegenerative and psychiatric animal models: Experimental strategies and main outcomes

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