Effects of early destruction of the mouse arcuate nucleus by monosodium glutamate on age-dependent natural killer activity

Belluardo, Natale; Mudò, Giuseppa; Bindoni, M

doi:10.1016/0006-8993(90)90132-u

Cited by 40 publications

(21 citation statements)

References 41 publications

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“…It is noteworthy that the effects observed in the BM, after MSG-lesion of arcuate nucleus are similar on both NK (Belluardo et al, 1990b) and NS cells, suggesting that they may be indirectly due to an effect on pluripotent stem cells of the BM. However, although NK and NS cells share some characteristics, it is still unclear whether they are generated from the same cell lineage (Syches, Sharabi & Sach, 1990;Saffran & Singhal, 1990).…”

Section: Discussionmentioning

confidence: 88%

“…Previously, we have observed that, after neonatal administration of MSG, the NK cell cytotoxic activity in the spleen remained reduced in the adulthood (Belluardo et al, 1990b). This premise prompted us to evaluate if the NS activity, like NK ac- tivity, also remain reduced during the adult age.…”

Section: Resultsmentioning

confidence: 96%

“…Concerning the effects of arcuate nucleus lesions on the endocrine system and vice versa, and the consequent possible repercussions on immune system, we refer to what we discussed in previous papers (Belluardo et al, 1987;Belluardo et al, 1990b). Because hormonal effects on NS activity has been poorly studied, specific study should be performed to verify any speculation.…”

Section: Discussionmentioning

confidence: 93%

“…Three to four animals per group were used in each experiment, which was repeated at least three times. The histological examination of MSG-induced brain lesions was performed as previously described (Belluardo et al, 1990b). Statistical analysis was performed by a two-way…”

Section: Methodsmentioning

confidence: 99%

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Neuroregulation of Natural Suppressor Cell Activity

Mudò

Bindoni

Belluardo

1994

International Journal of Neuroscience

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The neuronal control of murine natural suppressor (NS) cell activity was studied in mice following lesion of the arcuate nucleus of the hypothalamus performed by the postnatal treatment with monosodium glutamate (MSG). The suppressor activity was evaluated as the ability of spleen or bone marrow cells (suppressors) to suppress the mitogen-induced lymphocytes proliferation of allogeneic Balb/c spleen cells (indicators). The study was carried out on three different inbred strains of mice (C57BL/6, DBA/2 and CBA). The results demonstrated that, in all strains used, the treatment of mice (12 day-old) with MSG led to a marked reduction of natural suppressor cell activity. This reduction was observed in both spleen and bone marrow, the lymphoid organs in which the NS cell activity is usually present. A reduced NS activity was also present in the bone marrow of MSG-treated adult mice, suggesting a permanent alteration of NS cell activity. These results provide additional support on neuromodulation of immune system.

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Section: Discussionmentioning

confidence: 88%

Section: Resultsmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 93%

Section: Methodsmentioning

confidence: 99%

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Neuroregulation of Natural Suppressor Cell Activity

Mudò

Bindoni

Belluardo

1994

International Journal of Neuroscience

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“…Destruction of the hypothalamic arcuate nucleus with the neurotoxin monosodium glutamate results in depressed NKCC and proliferation of the large granular lymphocytes (LGL) and in the disappearance of its age-dependent pattern. 31 Hypophysectomy or adrenalectomy could reverse the effects of the preoptic/ anterior hypothalamus lesions, suggesting that the effects of these lesions on the immune system were mediated via the pituitary hormones or peptides or other neuroendocrine routes. 8 Mechanical lesion or isolation of the rat hypothalamic paraventricular nucleus (PVN) can selectively reduce the circulating white blood cells and the primary immune response, while it enhances cell-mediated immune function.…”

Section: Discussionmentioning

confidence: 99%

Acute Electrical Stimulation of Nucleus Ambiguus Enhances Immune Function in Rats

Mei¹,

Yang²,

Wang³

et al. 2008

Can. j. neurol. sci.

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It is well known that there exists bidirectional regulation in the central nervous system (CNS) and immune system. [1][2][3] The CNS can have a widespread effect on the immune system following the activation of the hypothalamic-pituitary-adrenal axis 4,5 and the sympathetic nervous system. 3,6,7 Thus far, many regions in the brain such as the hypothalamic nuclei, brain reward system, limbic structures, cortex, midbrain periaqueductal gray matter, cerebellum, circumventricular organs, and vagal complex have been identified as "immunoactive" areas. 8 The nucleus ambiguous (Amb), that is a nucleus of the vagus nerve, is located in the ventrolateral reticulate structure of the medulla oblongata. Thus far, probably owing to traditional ideas regarding this area, study of the Amb ABSTRACT: Background: Up to now, many ''immunoactive'' brain areas have been identified, such as hypothalamic nuclei, brain reward system; but the nucleus ambiguous (Amb), a nucleus nervi vagis of medulla oblongata, was less well studied in neuroimmunomodulation. Methods: In order to obtain more profound comprehension and more knowledge on Amb, we studied the effect of acute electrical stimulation of Amb on thymus and spleen activity in rat. A stimulator was applied to stimulate the Amb of the anaesthetic rats using the parameter at 100μA×5ms ×100 Hz every 1s for 1 min. The levels of TGF-β and thymosin-β4 mRNA in thymus, the release of IL-2 and IL-6 at splenocyte in vitro and splenic lymphocyte proliferation were measured at hour 0.5,1,2,3 following the electrical stimulation. Results: The results showed that concanavalin A (Con A)-induced splenic lymphocyte proliferation and the release of IL-2 and IL-6 were all significantly enhanced at 0.5, 1, and 2 h following effective Amb stimulation as compared to in the control group. However, as compared to in the control group, the levels of TGF-β and thymosin-β4 mRNA in the thymus were both remarkably reduced at 0.5, 1, and 2 h following effective Amb stimulation. Conclusions: These findings reveal that the Amb participates in the modulation of animal immune functions.RÉSUMÉ: La stimulation électrique aiguë du noyau ambigu stimule la fonction immunitaire chez le rat. Contexte : Plusieurs zones immunoactives du cerveau ont été identifiées jusqu'à maintenant, dont les noyaux hypothalamiques (corps de Luys, noyau sous-thalamique), le système de récompense du cerveau. Cependant, il existe peu d'études sur le rôle du noyau ambigu (Amb), le noyau du nerf vague situé dans le bulbe rachidien, dans la neuro-immunomodulation. Méthodes

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Acute myeloid leukemia in a twin with a suprasellar arachnoid cyst: a possible correlation

Gangarossa

1994

Child's Nerv Syst

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Effects of early destruction of the mouse arcuate nucleus by monosodium glutamate on age-dependent natural killer activity

Cited by 40 publications

References 41 publications

Neuroregulation of Natural Suppressor Cell Activity

Neuroregulation of Natural Suppressor Cell Activity

Acute Electrical Stimulation of Nucleus Ambiguus Enhances Immune Function in Rats

Acute myeloid leukemia in a twin with a suprasellar arachnoid cyst: a possible correlation

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