Effects of early handling on amphetamine-induced locomotor activation and conditioned place preference in the adult rat

Campbell, James; Spear, Linda P.

doi:10.1007/s002130050934

Cited by 59 publications

(38 citation statements)

References 45 publications

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“…All these behavioral effects of early handling may well increase an animal's willingness to interact with pups. The role of altered endocrinology in the behavioral effects are not at present clear, however, with some investigators finding an effect of early handling on open-field and other "emotion" tests (Caldji et al, 2000;Caldji et al, 1998;Meerlo, Horvath, Nagy, Bohus, & Koolhaas, 1999) and others finding no effect (Campbell & Spear, 1999).…”

Section: Effects Of Short Periods Of Separationmentioning

confidence: 99%

“…privation produces increased (Caldji et al, 2000) or no (Campbell & Spear, 1999;Lehmann, Pryce, Bettschen, & Feldon, 1999;Lovic et al, 2001) change in "fear" and "emotionality," as assessed by adult open-field activity and plus-maze performance. Despite these problems of interpretation,there is a substantial literature showing that early deprivation from mothers and the nest have long-term effects on the development of the animals' hypothalamic-pituitary-adrenal (HPA) system and responses to stressors (Anisman, Zaharia, Meaney, & Merali, 1998;Plotsky & Meaney, 1993).…”

mentioning

confidence: 99%

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How early maternal separation and juvenile experience with pups affect maternal behavior and emotionality in adult postpartum rats

Rees

Fleming

2001

Animal Learning & Behavior

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To assess the effects of preweaning and juvenile experiences on adult maternal behavior, two experiments were completed. In Experiment 1, pups were separated for long periods or short periods or were left undisturbed over the 1st week. Following weaning, the rats were exposed to foster pups over a 5-day period or were left undisturbed. There were no effects of early experience on juvenile behavior. In adult postpartum maternal tests, short separations reduced latencies to express maternal behaviors, whereas long separations combined with juvenile exposure to pups increased latencies. In Experiment 2, pups were separated for long periods or were left undisturbed over the 1st week. Following weaning, the rats were exposed to foster pups for 4 days or 8 days or were left undisturbed. Long separation retarded maternal responding in juvenile animals but had no effect on the adults. Four days of juvenile experience had negative effects on adult behavior, whereas 8 days did not have an effect.

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Section: Effects Of Short Periods Of Separationmentioning

confidence: 99%

mentioning

confidence: 99%

How early maternal separation and juvenile experience with pups affect maternal behavior and emotionality in adult postpartum rats

Rees

Fleming

2001

Animal Learning & Behavior

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“…Results indicated, however, that the magnitude of Mn-induced toxicity in the nucleus accumbens, and other relevant brain regions, was apparently insufficient to impair performance on the CPP task. Additionally, CPP performance has been reported to vary according to sex, with female rats and mice showing more robust place preferences than males (Russo et al, 2003;Balda et al, 2006; but see Crawford et al, 1995;Campbell and Spear, 1999). For this reason we included both sexes in the CPP experiment but found that (a) Mn did not differentially affect place preference conditioning of male and female rats, and (b) preference testing and reinstatement performance did not differ according to sex (perhaps due to insufficient n).…”

Section: Discussionmentioning

confidence: 99%

Postnatal manganese exposure alters dopamine transporter function in adult rats: Potential impact on nonassociative and associative processes

McDougall¹,

Reichel²,

Farley³

et al. 2008

Neuroscience

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In the present study, we examined whether exposing rats to a high-dose regimen of manganese chloride (Mn) during the postnatal period would depress presynaptic dopamine functioning and alter nonassociative and associative behaviors. To this end, rats were given oral supplements of Mn (750 μg/day) on postnatal days (PD) 1-21. On PD 90, dopamine transporter (DAT) immunoreactivity and [ 3 H]dopamine uptake were assayed in the striatum and nucleus accumbens, while in vivo microdialysis was used to measure dopamine efflux in the same brain regions. The effects of postnatal Mn exposure on nigrostriatal functioning were evaluated by assessing rotorod performance and amphetamine-induced stereotypy in adulthood. In terms of associative processes, both cocaineinduced conditioned place preference (CPP) and sucrose-reinforced operant responding were examined. Results showed that postnatal Mn exposure caused persistent declines in DAT protein expression and [ 3 H]dopamine uptake in the striatum and nucleus accumbens, as well as long-term reductions in striatal dopamine efflux. Rotorod performance did not differ according to exposure condition, however Mn-exposed rats did exhibit substantially more amphetamine-induced stereotypy than vehicle controls. Mn exposure did not alter performance on any aspect of the CPP task (preference, extinction, or reinstatement testing), nor did Mn affect progressive ratio responding (a measure of motivation). Interestingly, acquisition of a fixed ratio task was impaired in Mn-exposed rats, suggesting a deficit in procedural learning. In sum, these results indicate that postnatal Mn exposure causes persistent declines in various indices of presynaptic dopaminergic functioning. Mninduced alterations in striatal functioning may have long-term impact on associative and nonassociative behavior.

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“…Campbell and Spear (1999) found that brief neonatal isolation attenuates amphetamine CPP during early adulthood. With cocaine self-administration, MS15 male and female rats fail to acquire cocaine self-administration with a unit dose (0.0625 mg/kg per infusion) that supports self-administration in controls and MS180 rats .…”

Section: B Social Influencesmentioning

confidence: 95%

Individual Differences and Social Influences on the Neurobehavioral Pharmacology of Abused Drugs

2013

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Effects of early handling on amphetamine-induced locomotor activation and conditioned place preference in the adult rat

Cited by 59 publications

References 45 publications

How early maternal separation and juvenile experience with pups affect maternal behavior and emotionality in adult postpartum rats

How early maternal separation and juvenile experience with pups affect maternal behavior and emotionality in adult postpartum rats

Postnatal manganese exposure alters dopamine transporter function in adult rats: Potential impact on nonassociative and associative processes

Individual Differences and Social Influences on the Neurobehavioral Pharmacology of Abused Drugs

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