Effects of early life exposure to home environmental factors on childhood allergic rhinitis: Modifications by outdoor air pollution and temperature

Lu, Chan; Liu, Zijing; Liao, Hongsen; Yang, Wenhui; Li, Qin; Liu, Qin

doi:10.1016/j.ecoenv.2022.114076

Cited by 32 publications

(7 citation statements)

References 97 publications

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“…Previous studies have found a correlation between other environmental factors and stroke occurrence ( 16 – 20 ), which may modify the relationship between ambient temperature and stroke ( 21 – 23 ); therefore, in our study, we evaluated the effect of ambient temperature alone and then combined the modified effects of multiple environmental factors to consider their effects on stroke occurrence. Since the effect of ambient temperature on stroke incidence is non-linear and lagged ( 9 , 24 , 25 ), we used a distributed lagged non-linear model to analyze stroke emergency department visit data in Beijing from 2017 to 2018, in addition, we explored the effect of temperature and specific environmental factors on stroke by developing a generalized additive model.…”

Section: Introductionmentioning

confidence: 99%

Effect of ambient temperature and other environmental factors on stroke emergency department visits in Beijing: A distributed lag non-linear model

Zhao

Zhang

Ying

et al. 2022

Front. Public Health

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BackgroundMost studies have focused on the relationship between ambient temperature and stroke mortality, but studies on the relationship between ambient temperature and stroke occurrence are still limited and inconsistent.ObjectiveThis study aimed to analyze the effect of ambient temperature and other environmental factors on emergency stroke visits in Beijing.MethodsOur study utilized stroke visit data from the Beijing Red Cross Emergency Medical Center during 2017–2018, and applied a generalized additive model (GAM) as well as a distributed lag non-linear model (DLNM), respectively, regarding the direct, lagged, and cumulative effects of ambient temperature alone and with correction for other environmental factors on stroke occurrence.ResultsWith a total of 26,984 emergency stroke patients in 2017–2018, both cold and hot effects were observed and weakened after correction for other environmental factors. Compared to the reference temperature, in the multi-factor model, extreme cold (−10°C) reached a maximum relative risk (RR) of 1.20 [95% Confidence Interval (CI): 1.09, 1.32] at lag 14 days, and extreme hot (30°C) had a maximum RR of 1.07 (95% CI: 1.04, 1.11) at lag 6 days. The cumulative effect of extreme cold reached a maximum of 2.02 (95% CI: 1.11, 3.67) at lag 0–14 days, whereas the cumulative effect of extreme hot temperature is greatest at lag 0–10 days, but no statistically significant effect was found. In addition, ischemic stroke patients, the elderly, and males were more susceptible to the effects of cold temperature.ConclusionsThere is a non-linear relationship between ambient temperature and stroke occurrence, with cold temperature having a greater and longer-lasting impact than hot temperature.

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Section: Introductionmentioning

confidence: 99%

Effect of ambient temperature and other environmental factors on stroke emergency department visits in Beijing: A distributed lag non-linear model

Zhao

Zhang

Ying

et al. 2022

Front. Public Health

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“… 65 Given that postnatal exposure to

was also associated with AR risk in children, further studies are warranted to confirm the interaction between

and PUFAs across different exposure windows in early life. Fifth, we have considered the potential influence of household mold and dampness in our sensitivity analysis, but the unmeasured confounding effect of other indoor environmental factors (e.g., air pollution from renovations 66 ) should be better addressed in future research. Sixth, this study investigated early onset AR outcomes in children up to 2 years of age.…”

Section: Discussionmentioning

confidence: 99%

The Associations of Prenatal Exposure to Fine Particulate Matter and Its Chemical Components with Allergic Rhinitis in Children and the Modification Effect of Polyunsaturated Fatty Acids: A Birth Cohort Study

Chen,

Guo,

Chung

et al. 2024

Environ Health Perspect

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Background: Polyunsaturated fatty acids (PUFAs) have been shown to protect against fine particulate matter in aerodynamic diameter ( )-induced hazards. However, limited evidence is available for respiratory health, particularly in pregnant women and their offspring. Objectives: We aimed to investigate the association of prenatal exposure to and its chemical components with allergic rhinitis (AR) in children and explore effect modification by maternal erythrocyte PUFAs. Methods: This prospective birth cohort study involved 657 mother–child pairs from Guangzhou, China. Prenatal exposure to residential mass and its components [black carbon (BC), organic matter (OM), sulfate ( ), nitrate ( ), and ammonium ( )] were estimated by an established spatiotemporal model. Maternal erythrocyte PUFAs during pregnancy were measured using gas chromatography. The diagnosis of AR and report of AR symptoms in children were assessed up to 2 years of age. We used Cox regression with the quantile-based g-computation approach to assess the individual and joint effects of components and examine the modification effects of maternal PUFA levels. Results: Approximately and 8.07% of children had AR and related symptoms, respectively. The average concentration of prenatal was . was positively associated with the risk of developing AR [hazard ratio ; 95% confidence interval (CI): 1.16, 2.96 per ] and its symptoms ( ; 95% CI: 1.22, 2.62 per ) after adjustment for confounders. Similar associations were observed between individual components and AR outcomes. Each quintile change in a mixture of components was associated with an adjusted HR of 3.73 (95% CI: 1.80, 7.73) and 2.69 (95% CI: 1.55, 4.67) for AR and AR symptoms, with BC accounting for the largest contribution. Higher levels of n-3 docosapentaenoic acid and lower levels of n-6 linoleic acid showed alleviating effects on AR symptoms risk associated with exposure to and its components. Conclusion: Prenatal exposure to and its chemical components, particularly BC, was associated with AR/symptoms in early childhood. We highlight that PUFA biomarkers could modify the adverse effects of on respiratory allergy. https://doi.org/10.1289/EHP13524

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“…that bear sequelae over the course of an entire lifetime [7]. Exposures to indoor air pollutants in early childhood also tend to have repercussions throughout life [8,9]. It is common sense that the respiratory system bears the maximum brunt as these pollutants get inhaled, affecting the respiratory pathway all the way from the nose to the alveoli.…”

Section: Discussionmentioning

confidence: 99%

Geospatial Mapping of Indoor Air Quality and Respiratory Illnesses in an Urban Slum

Shah¹,

Shabadi²,

Karkra³

et al. 2023

Cureus

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IntroductionAir pollution is a well-recognized determinant of health. The general perception has focused primarily on outdoor pollution, and indoor pollution which may be due to smoking, biomass use, an extension of outdoor pollution, etc. has been neglected. It is therefore imperative to understand the levels of indoor pollution and find out if these are associated with high rates of illnesses, particularly, respiratory diseases. Material and methodsThis was a cross-sectional study involving 300 houses and 727 participants in an urban slum, selected through simple random sampling. Indoor air quality was assessed using the Prana C -Air Plus air quality monitor (Prana Air, New Delhi, India). The instrument detected formaldehyde, air quality index (AQI), temperature, humidity, PM2.5, PM10 particles, and total volatile organic (TVO) compounds. Sociodemographic details were noted, and geospatial mapping was done using Q-GIS software (www.qgis.org). A questionnaire was used to survey the residents of those houses. Ethical committee clearance was obtained before starting the project. ResultsThe mean distribution of pollution parameters over the entire study area was AQI -67.4±65.48, PM 2.5 -37.6±35.82 μg/m 3 , formaldehyde -0.09±0.37 mg/m 3 , PM 10 -43.9±38.59 μg/m 3 , TVO compounds -0.43±2.13 mg/m 3 , CO 2 -1128.9±323.86 ppm, temperature -23.7±21.2 degree Celsius, and PM 1 -24.3±20.5 μg/m 3 ; 2.6% of the participants had respiratory diseases, and a significant association was found between the AQI, TVO compounds and ventilation, and respiratory diseases (p<0.05). ConclusionIndoor air pollution not unlike outdoor pollution can have dramatic health effects and needs to be addressed to lower the overall respiratory disease burden. The AQI, TVOC, and poor ventilation/cross-ventilation are associated with respiratory illnesses. Geospatial mapping shows a concentration of cases in areas of high pollution.

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Effects of early life exposure to home environmental factors on childhood allergic rhinitis: Modifications by outdoor air pollution and temperature

Cited by 32 publications

References 97 publications

Effect of ambient temperature and other environmental factors on stroke emergency department visits in Beijing: A distributed lag non-linear model

Effect of ambient temperature and other environmental factors on stroke emergency department visits in Beijing: A distributed lag non-linear model

The Associations of Prenatal Exposure to Fine Particulate Matter and Its Chemical Components with Allergic Rhinitis in Children and the Modification Effect of Polyunsaturated Fatty Acids: A Birth Cohort Study

Geospatial Mapping of Indoor Air Quality and Respiratory Illnesses in an Urban Slum

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