Effects of early menarche on physical and psychosocial health problems in adolescent girls and adult women

Yoo, Jae Ho

doi:10.3345/kjp.2016.59.9.355

Cited by 44 publications

(36 citation statements)

References 37 publications

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“…CPP disproportionately affects girls compared to boys; the mechanisms leading to these differences are unknown (24). Understanding more common causes of CPP, including genetic etiologies, is vital given that CPP has important short-and longterm implications for women, including increased risk of psychosocial distress, short stature, obesity, cardiovascular disease and type 2 diabetes in adulthood (25).…”

Section: Central Precocious Pubertymentioning

confidence: 99%

GENETICS IN ENDOCRINOLOGY: Genetic etiologies of central precocious puberty and the role of imprinted genes

Roberts

Kaiser

2020

European Journal of Endocrinology

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Pubertal timing is regulated by the complex interplay of genetic, environmental, nutritional and epigenetic factors. Criteria for determining normal pubertal timing, and thus the definition of precocious puberty, have evolved based on published population studies. The significance of the genetic influence on pubertal timing is supported by familial pubertal timing and twin studies. In contrast to the many monogenic causes associated with hypogonadotropic hypogonadism, only four monogenic causes of central precocious puberty (CPP) have been described. Loss-of-function mutations in Makorin Ring Finger Protein 3 (MKRN3), a maternally imprinted gene on chromosome 15 within the Prader-Willi syndrome locus, are the most common identified genetic cause of CPP. More recently, several mutations in a second maternally imprinted gene, Delta-like noncanonical Notch ligand 1 (DLK1), have also been associated with CPP. Polymorphisms in both genes have also been associated with age of menarche in genome-wide association studies. Mutations in the genes encoding kisspeptin (KISS1) and its receptor (KISS1R), potent activators of GnRH secretion, have also been described in association with CPP, but remain rare monogenic causes. CPP has both short- and long-term health implications for children, highlighting the importance of understanding the mechanisms contributing to early puberty. Additionally, given the role of mutations in the imprinted genes MKRN3 and DLK1 in pubertal timing, other imprinted candidate genes should be considered for a role in puberty initiation.

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Section: Central Precocious Pubertymentioning

confidence: 99%

GENETICS IN ENDOCRINOLOGY: Genetic etiologies of central precocious puberty and the role of imprinted genes

Roberts

Kaiser

2020

European Journal of Endocrinology

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“…As such, menarche occurring prior to age 12 is considered early and from 14 years onwards is considered late (Karapanou & Papadimitriou, 2010; Marino et al., 2013; Wijnhoven et al., 2006). The onset and timing of menarche, early or late, appears to be associated with lifelong adverse health and social outcomes (Aegidius et al., 2011; Karapanou & Papadimitriou, 2010; Kvalheim et al., 2016; Le‐Ha et al., 2018; Mishra et al., 2009; Yoo, 2016). Early menarche shares a relationship with a number of diseases including higher risk of breast and endometrial cancers, obesity, diabetes, cardiovascular disease and menstrual/reproductive disorders (Aegidius et al., 2011; Karapanou & Papadimitriou, 2010; Kvalheim et al., 2016; Le‐Ha et al., 2018; Mishra et al., 2009; Yoo, 2016).…”

Section: Introductionmentioning

confidence: 99%

Early age at menarche is associated with post‐menarche back pain: An analysis of the Raine Study

Innes

Jacques

Scott

et al. 2021

European Journal of Pain

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Introduction Back pain (BP) experienced by females during adolescent years appears to predispose them to an increased likelihood of its presence in adulthood. Understanding this phenomenon by identifying risk factors of those at risk potentially fosters preventative strategies and effective treatments. Objectives To investigate for associations between post‐menarche BP and low back pain (LBP) and age at menarche (AAM) in Australian adolescents using the Western Australian pregnancy cohort (The Raine Study). Methods This study used data from a longitudinal cohort study. BP data were collected retrospectively using a questionnaire. Menarche data was split into three established age classifications early (<12‐years), normal (≥12 to >14‐years) and late (≥14‐years). Logistic regression models examined the effect of AAM on BP. Results 666 female participants provided valid menarche data with 183 (27.5%) early AAM, 429 (64.4%) normal AAM and 54 (8.1%) with late AAM. The mean AAM was 12.59 years. BP was disclosed by 27.5% in the 14‐year follow‐up and 31.5% in the 17‐year follow‐up. Participants who had early AAM had 79% higher odds of experiencing BP compared to participants who had normal AAM, after adjusting for confounders at the 14‐year follow‐up (adjOR 1.79, 95% CI 1.18–2.64). Conclusion There is evidence of an association, in this cohort, of early AAM with post‐menarche BP. This result identifies an area for future exploration, including understanding this mechanism which may lead to the development of effective intervention measures. Significance Age at menarche is related to a range of health issues. This study sought to investigate if it was a risk factor for spinal pain. We used an existing Australian data base to explore this possibility and found an association with early age onset and post‐menarche back pain. This result identifies an area for future exploration, including understanding this mechanism which may lead to the development of effective intervention measures.

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“…Obesity influences the onset of puberty as gonadal function is regulated by metabolic status. Insulin and leptin indirectly impinge hypothalamic neurons emitting gonadotropin-releasing hormone, a hierarchical hormone within the hypothalamic-pituitary-gonadal (HPG) axis [129,130]. As the prevalence of childhood obesity has increased, a study found that the median age at menarche decreased by 3-5.5 months in the US between the late 1960s and 1990 [8].…”

Section: Reproductive Healthmentioning

confidence: 99%

Physical and Mental Health Consequences of Obesity in Women

Weschenfelder¹,

Bentley²,

Himmerich

2018

Adipose Tissue

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Obesity and overweight are major health concerns and the leading preventable cause of death in developed and developing countries. Obesity affects men and women differently due to biological, socioeconomic, cultural and country-specific gender-related disparities. This book chapter outlines obesity as a risk factor for physical diseases and mental health disorders in women. Obesity has been shown to contribute to the risk of certain types of cancer, including breast, endometrial, gallbladder, oesophageal and renal cancer. In terms of reproductive health, obesity negatively affects both fertility and contraception. In addition, obesity is associated with early miscarriage, higher rates of caesarean section and high-risk obstetrical conditions, in addition to higher maternal and neonatal mortality rates, and congenital malformations. In terms of mental health, obesity is closely linked to depression, anxiety disorders, neurodegenerative diseases and sleep disorders. Socioeconomic, psychosocial and behavioural factors, factors associated with ageing, mechanisms related to the microbiome, gastrointestinal and vascular system, intracellular pathophysiology and metabolism in the body, hormones, adipocytokines and problems associated with medical treatment are important factors linking obesity with its negative consequences on physical and mental health.

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Effects of early menarche on physical and psychosocial health problems in adolescent girls and adult women

Cited by 44 publications

References 37 publications

GENETICS IN ENDOCRINOLOGY: Genetic etiologies of central precocious puberty and the role of imprinted genes

GENETICS IN ENDOCRINOLOGY: Genetic etiologies of central precocious puberty and the role of imprinted genes

Early age at menarche is associated with post‐menarche back pain: An analysis of the Raine Study

Physical and Mental Health Consequences of Obesity in Women

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