Effects of early nutritional intervention by a nutritional support team for patients with head and neck cancer undergoing chemoradiotherapy or radiotherapy

Kono, Michihisa; Wakisaka, Risa; Kumai, Takumi; Hayashi, Ryusuke; Komatsuda, Hiroki; Sato, Ryosuke; Abe, Yasushi; Yamaki, Hidekiyo; Takahara, Miki; Katada, Akihiro; Hayashi, Tatsuya; Harabuchi, Yasuaki

doi:10.1002/hed.26502

Cited by 15 publications

(8 citation statements)

References 20 publications

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“…43 It has been stated that preoperative nutritional intervention can improve outcomes in HNC patients when appropriately applied, and it is reasonable to consider that the same principles could apply to maxillofacial trauma patients. 44 Given that facial fractures are infrequently emergent operations, preoperative nutritional intervention could impact outcomes in these maxillofacial trauma patients if recognized early in the evaluation process. The enhanced recovery after surgery (ERAS) protocol has been demonstrated to improve outcomes in many surgical disciplines including orthognathic surgery, spine, and gastrointestinal.…”

Section: Discussionmentioning

confidence: 99%

“…Patients presenting with facial fractures commonly have pain that prevents adequate caloric intake in addition to dietary restrictions perioperatively that have been shown to impact wound healing and weight loss 43 . It has been stated that preoperative nutritional intervention can improve outcomes in HNC patients when appropriately applied, and it is reasonable to consider that the same principles could apply to maxillofacial trauma patients 44 . Given that facial fractures are infrequently emergent operations, preoperative nutritional intervention could impact outcomes in these maxillofacial trauma patients if recognized early in the evaluation process.…”

Section: Discussionmentioning

confidence: 99%

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Preoperative Nutritional Laboratory Values, Demographics, and Wound Healing Following Facial Trauma Surgery: Which Variables Predict Postoperative Complications?

Fahmy

Clegg

Deek

et al. 2023

Journal of Craniofacial Surgery

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In individuals who have sustained maxillofacial trauma, inadequate nutrition is often a sequela and may lead to complications. The purpose of this study was to investigate the association between preoperative laboratory values and postoperative complications in patients with maxillofacial trauma requiring surgical intervention.A retrospective cohort study of patients with maxillofacial trauma requiring surgical repair from 2014 to 2020 was performed at a single academic Level I Trauma Center. The primary predictor variables were preoperative laboratory values including serum albumin, white blood cell count, absolute neutrophil count, and lymphocyte count. Complications related to surgical reconstruction of facial injuries represented the primary outcome variable.The patient cohort included 152 patients, of whom 50 (32.9%) were female. When controlling for all other variables, female gender (odds ratio = 2.08, 95% confidence interval, 1.02-4.21; P = 0.04) and number of procedures performed (P = 0.02) were the only statistically significant predictors of postoperative complications. There were no significant differences between the complication groups for age (P = 0.89), injury severity score (P = 0.59), hospital length of stay (P = 0.30), serum albumin (P = 0.86), hemoglobin (P = 0.06), white blood cell count (P = 0.20), absolute neutrophil count (P = 0.95), lymphocyte count (P = 0.23), or absolute neutrophil/lymphocyte count ratio (P = 0.09).In this study, it was found that only gender and the number of procedures performed significantly predicted postoperative complications, while preoperative nutritional laboratory values did not. Further study with a larger cohort of patients is likely required.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Preoperative Nutritional Laboratory Values, Demographics, and Wound Healing Following Facial Trauma Surgery: Which Variables Predict Postoperative Complications?

Fahmy

Clegg

Deek

et al. 2023

Journal of Craniofacial Surgery

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“…Enhanced services could also include nutritional support. A report by Kono et al among HNC patients showed that early nutritional intervention by a nutritional support team had significantly positive results [ 35 ]. Those in the intervention arm experienced less weight loss than those in the nonintervention arm 3.3% vs. 7.3% and had far fewer instances of Grade 3 mucositis (25.0% vs. 70.0%).…”

Section: Discussionmentioning

confidence: 99%

A Retrospective Cohort Study of Myosteatosis and Quality of Life in Head and Neck Cancer Patients

Shaver

Noyes

Ochs‐Balcom

et al. 2021

Cancers

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Head and neck cancer (HNC) treatment-related morbidity can be detrimental to quality of life (QOL). Myosteatosis is associated with poor QOL in multiple cancers. If predictive of poor QOL trajectories, myosteatosis would be a tool for clinicians to determine which patients may require additional support during treatment. The purpose of this study was to determine if pretreatment myosteatosis is associated with a poor QOL trajectory following treatment completion. Methods: In a retrospective cohort design, myosteatosis was determined from pretreatment CT scans. Both physical and global QOL score was assessed through patient interview on follow-up appointment. Demographic, cancer-specific, and social covariates were collected, reported, and considered as potential confounders. Results: The population of 163 patients was mostly male (82.2%) and white (91.4%) with oropharyngeal cancer (55.8%). Males with myosteatosis had a physical QOL score 46.84 points lower at one-year following treatment completion (p = 0.01) than those with normal muscle density (p = 0.01). Males with myosteatosis averaged 57.57 points lower at one-year post-treatment (p = 0.01) in global QOL scores. Conclusions: Over one year following completion of treatment, patients with myosteatosis reported worse physical and global QOL scores than patients with normal muscle density.

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“…And the decrease in hemoglobin reflects deficiencies in many nutrients, such as iron and vitamins (especially B12). Early nutritional intervention by a multidisciplinary nutritional support team improved body weight loss rate, mucositis, albumin level, and hospital length of stay, which might lead to better clinical outcomes ( 88 ). Therefore, early nutritional intervention may contribute to improve malnutrition of patients.…”

Section: Clinical Intervention For Riom and Malnutrition In Hnc Patiementioning

confidence: 99%

The Effects of Early Nutritional Intervention on Oral Mucositis and Nutritional Status of Patients With Head and Neck Cancer Treated With Radiotherapy

Zheng

Zhao

et al. 2021

Front. Oncol.

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Radiation-induced oral mucositis (RIOM) is a common side effect after radiotherapy (RT) in head and neck cancer (HNC) patients. RIOM patients with severe pain have difficulty in eating, which increases the incidence of malnutrition and affects patients’ quality of life and the process of RT. The mechanism of RIOM is not fully understood, and inflammatory response and oxidative stress appear to be important for RIOM occurrence and development. The nutritional status of patients is very important for their RT tolerance and recovery. Malnutrition, which can lead to anemia, low protein, decreased immunity and other problems, is an important clinical factor affecting tumor progression and treatment. Recent studies have shown that early nutritional intervention can ameliorate oral mucositis and nutritional status of patients with HNC. However, in clinical practice, early nutritional intervention for patients with HNC is not a conventional intervention strategy. Therefore, this review summarized the possible pathogenesis of RIOM, commonly used assessment tools for malnutrition in patients, and recent studies on the effects of early nutritional interventions on RIOM and nutritional status of patients with HNC. We hope to provide the basis and reference for the clinical application of early nutritional intervention models.

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Effects of early nutritional intervention by a nutritional support team for patients with head and neck cancer undergoing chemoradiotherapy or radiotherapy

Cited by 15 publications

References 20 publications

Preoperative Nutritional Laboratory Values, Demographics, and Wound Healing Following Facial Trauma Surgery: Which Variables Predict Postoperative Complications?

Preoperative Nutritional Laboratory Values, Demographics, and Wound Healing Following Facial Trauma Surgery: Which Variables Predict Postoperative Complications?

A Retrospective Cohort Study of Myosteatosis and Quality of Life in Head and Neck Cancer Patients

The Effects of Early Nutritional Intervention on Oral Mucositis and Nutritional Status of Patients With Head and Neck Cancer Treated With Radiotherapy

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