Effects of early postoperative nasal decongestant on symptom relief after septoplasty

Dağlı, Elif; Ocak, Emre; Mirici, Emre; Kaya, Mesut; Acar, Ali

doi:10.1002/alr.22183

Cited by 5 publications

(5 citation statements)

References 11 publications

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“…Oxymetazoline nasal spray is found to be non-inferior to cocaine and epinephrine in nasal surgeries with the benefit of less systemic complications of arrhythmia, hypertension and cardiac arrest [8]. The benefits of oxymetazoline nasal spray when given post-operatively after nasal septoplasty include reduced bleeding and crust formation in the early post-operative period [9]. In our study, the benefit of adding oxymetazoline nasal spray post-operatively after DCR to decrease congestion and pain and minimize bleeding was not demonstrated as compared to 0.65% NaCl nasal spray.…”

Section: Discussionmentioning

confidence: 99%

A randomized controlled trial on the effects of oxymetazoline nasal spray after dacryocystorhinostomy among adult patients

Sosuan¹,

Ranche²,

Lagunzad³

2020

BMC Res Notes

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Objectives The study aimed to determine the effect of oxymetazoline nasal spray on the patency of the fistula created after dacryocystorhinostomy, specifically: to compare the success of fistula formation with oxymetazoline versus placebo, and to compare the incidence of post-operative congestion, pain and bleeding with oxymetazoline versus placebo. Results The study was a single-center, randomized controlled, triple-masked study involving the patients of the Plastic-Lacrimal service of a national university hospital. Block randomization was done. Dacryocystorhinostomy was performed by a single-masked surgeon. The intervention group used oxymetazoline. The placebo group used sodium chloride. The data were collected by another masked investigator. The study showed no significant difference in terms of congestion, pain and epistaxis between the two groups at day 2 post-operation. The patency, presence of silicone tube, granuloma formation, and presence of bleeding on both day 2 and day 16 post-operation had no difference between the two groups. This study doesn’t support the use of oxymetazoline nasal spray after DCR, since it does not decrease the symptoms of congestion, pain and epistaxis after DCR. Aside from being an additional expense for patients, it also does not affect fistula formation and success rate of the surgery. Trial registration Australian New Zealand Clinical Trial Registry: ACTRN12619001394134, Date registered 10/11/2019, Retrospectively Registered.

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Section: Discussionmentioning

confidence: 99%

A randomized controlled trial on the effects of oxymetazoline nasal spray after dacryocystorhinostomy among adult patients

Sosuan¹,

Ranche²,

Lagunzad³

2020

BMC Res Notes

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“…Oxymetazoline has potent decongestant effects, and in some studies has affected NOSE values in septoplasty patients and PNIF values in healthy patients. 6,7 The trigeminal nerve receptors and their function play an important role in nasal sensation. When stimulated by eucalyptol, the TRPM8 receptor creates the feeling of a clear nasal passage.…”

Section: Discussionmentioning

confidence: 99%

“…We found a significant difference between the change in assessments with control intranasal spray compared with the change assessments with oxymetazoline intranasal spray in TNSS, and did not find a difference in NOSE or PNIF. Oxymetazoline has potent decongestant effects, and in some studies has affected NOSE values in septoplasty patients and PNIF values in healthy patients 6,7 …”

Section: Discussionmentioning

confidence: 99%

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Role of trigeminal sensation in patients without nasal obstruction: A pilot study

Durrant

Salvador

Chen

et al. 2023

Int Forum Allergy Rhinol

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“…The current study investigated the sensory perception of two decongesting nasal sprays, new galenics and comparator, in patients during convalescence from surgery on the nasal septum or nasal conchae. The use of decongestants as medical treatment after nasal surgery aims to reduce mucosal oedema by inducing vasoconstriction, and beneficial effects on nasal symptoms after septoplasty have been demonstrated [ 8 ]. However, cytotoxic and ciliary-toxic effects observed in in vitro studies may indicate a limit in decongestant application, and the risk of rebound swelling after decongestant discontinuation should always be considered [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

The Contribution of Galenics to Patients’ Sensory Perception of Nasal Sprays After Nasal Surgery: Data from a Prospective Randomised, Controlled, Double-Blind, Crossover, Multicentre Study

Bergmann¹,

Lander

Radtke³

et al. 2021

Adv Ther

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Introduction: Postoperative care after nasal surgery is commonly achieved with nasal sprays. The current study compared two decongesting, wound-healing nasal sprays in patients after nasal surgery in order to investigate their sensory perception. One of the sprays was a new galenic formulation (nasic Ò neo, Cassella-med GmbH & Co. KG). Methods: According to the crossover design, patients who had undergone nasal surgery applied two different nasal sprays during two treatment periods of 4 days each, interrupted by a 3-day washout period. Sensory perception of the nasal sprays was assessed with the nasal spray sensoric scale. Throughout the study, nasal obstruction was evaluated by patients, and physical examinations, measurements of vital parameters and rhinoscopic examinations were carried out by investigators. Adverse events were documented during the entire study, and following treatment, patients judged the overall preference, efficacy and tolerability of both products. Results: Overall, no significant differences in sum scores of the assessments of the nasal spray sensoric scale were observed between treatments. A significant period effect observed during the crossover study limited the overall analysis. Nevertheless, significantly more patients preferred the new galenics nasal spray compared to the comparator spray (57.1% vs. 34.7%; p = 0.031). Further, 10% more patients rated the efficacy of the new galenics as 'good' to 'very good' compared to the comparator. Importantly, a subgroup population of patients with more pronounced signs of inflammation present at screening evaluated the sensory perception of the new galenics as significantly better (p = 0.033) compared to the comparator.Christoph Bergmann and Jennifer Lander contributed equally to the manuscript.

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Effects of early postoperative nasal decongestant on symptom relief after septoplasty

Abstract: The use of nasal decongestant sprays in the very early postoperative period is beneficial to reduce the postsurgical nasal crusting and bleeding symptoms and also for decreasing nasal resistance in this edematous period.

Cited by 5 publications

References 11 publications

A randomized controlled trial on the effects of oxymetazoline nasal spray after dacryocystorhinostomy among adult patients

A randomized controlled trial on the effects of oxymetazoline nasal spray after dacryocystorhinostomy among adult patients

Role of trigeminal sensation in patients without nasal obstruction: A pilot study

The Contribution of Galenics to Patients’ Sensory Perception of Nasal Sprays After Nasal Surgery: Data from a Prospective Randomised, Controlled, Double-Blind, Crossover, Multicentre Study

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