Effects of early spatial training on water maze performance: a longitudinal study in mice

Vicens, Paloma; Redolat, Rosa; Carrasco, M.C.

doi:10.1016/s0531-5565(01)00217-0

Cited by 40 publications

(28 citation statements)

References 27 publications

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“…Although sensitive to muscarinic blockade (Rasmussen and FinkJensen 2000;Eriksson et al 2008), this mouse strain is widely used for its sensitivity to antidepressants (van der (Moragrega et al 2002) and its high startle amplitude in sensory-motor gaiting tests (Yilmazer-Hanke et al 2003). NMRI mice have been extensively tested in spatial tasks including the water maze and young mice readily acquire this task Gower 1990, 1993;Klapdor and van der Staay 1996;Vicens et al 1999Vicens et al , 2002 with females showing better spatial skills than males (Lamberty and Gower 1988). Aging animals present with a strong progressive cognitive decay starting at 9-12 months of age (Lamberty and Gower 1990) but benefit considerably from previous experience in their youth (Vicens et al 1999.…”

Section: Discussionmentioning

confidence: 99%

Methylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine

et al. 2008

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Section: Discussionmentioning

confidence: 99%

Methylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine

et al. 2008

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“…For example, in a combined longitudinal and cross-sectional study, previous experience in the MWM prevented age-related impairments of Sprague-Dawley rats in the same task (Dellu et al 1997). The benefits of previous experience on water-maze performance have also been reported in mice (Vicens et al 1999(Vicens et al , 2002, but the extent of the benefit is strain dependent.…”

Section: Learning and Memory 467mentioning

confidence: 96%

“…Previous experience and consistent testing conditions have been reported to have a beneficial influence on learning and memory performance in other models of cognitive impairment, particularly aging (Dellu et al 1997;Vicens et al 1999Vicens et al , 2002Markowska and Savonenko 2002). For example, in a combined longitudinal and cross-sectional study, previous experience in the MWM prevented age-related impairments of Sprague-Dawley rats in the same task (Dellu et al 1997).…”

Section: Learning and Memory 467mentioning

confidence: 99%

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Cognitive performance is highly sensitive to prior experience in mice with a learning and memory deficit: Failure leads to more failure

Hebda-Bauer¹,

Watson²,

Akil³

2005

Learn. Mem.

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The impact of a previously successful or unsuccessful experience on the subsequent acquisition of a related task is not well understood. The nature of past experience may have even greater impact in individuals with learning deficits, as their cognitive processes can be easily disrupted. Mice with a targeted disruption of the ␣ and ␦ isoforms of the cAMP-response element-binding protein (CREB) gene (CREB ␣␦− -deficient mice) have a genetic vulnerability to impaired learning and memory that is highly influenced by experimental conditions. Thus, we studied the impact of prior successful and unsuccessful experiences on the degree to which CREB ␣␦− -deficient mice exhibit impaired spatial learning and memory in the Morris water maze (MWM). In Experiment 1, we replicated the cognitive deficit of CREB ␣␦− -deficient mice when given two trials per day with a 1-min intertrial interval (MWM2), and labeled this experience as a "failure." We rescued the deficit using four trials per day with a 3-to 5-min intertrial interval (MWM4) and labeled this experience a "success." In Experiment 2, a new, naive set of wild-type (WT) and CREB ␣␦− -deficient mice were randomly assigned to one of two sequence protocols to assess the influence of a success or a failure on subsequent performance. In Group 1, mice were first exposed to the MWM4 condition, followed by the more difficult MWM2 task. As expected, CREB ␣␦− -deficient mice performed well in the MWM4; they also performed well during reversal testing (MWM4R) where the goal location is changed. With this initial successful learning experience, the CREB ␣␦− -deficient mice then performed as well as WT mice in the MWM2, the condition in which they are known to be impaired. In contrast, CREB ␣␦− -deficient mice in Group 2 had an unsuccessful experience when first exposed to the MWM2 condition, and then also showed impairment in the MWM4, the condition in which they would normally perform well. This deficit was amplified when CREB ␣␦− -deficient mice were then tested in the reversal test. Sex differences in learning among CREB ␣␦− -deficient mice were amplified upon exposure to an unsuccessful learning experience. These data indicate that, under conditions of cognitive impairment, past experience can-depending on its nature-significantly facilitate or hinder future performance.

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“…First, previous animal studies in which aged subjects are provided with environmental enrichment have had small inconsistent effects on cognition [47]. By contrast, training animals on particular tasks early in life can produce long-lasting changes in the animals' abilities to learn those tasks later in life [49].…”

Section: Effects Of Behavioral Enrichmentmentioning

confidence: 99%

Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study

Milgram

2004

Neurobiology of Aging

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The effectiveness of two interventions, dietary fortification with antioxidants and a program of behavioral enrichment, was assessed in a longitudinal study of cognitive aging in beagle dogs. A baseline protocol of cognitive testing was used to select four cognitively equivalent groups: control food-control experience (C-C), control food-enriched experience (C-E), antioxidant fortified food-control experience (A-C), and antioxidant fortified food-enriched experience(A-E). We also included two groups of young behaviorally enriched dogs, one receiving the control food and the other the fortified food. Discrimination learning and reversal was assessed after one year of treatment with a size discrimination task, and again after two years with a black/white discrimination task. The four aged groups were comparable at baseline. At one and two years, the aged combined treatment group showed more accurate learning than the other aged groups. Discrimination learning was significantly improved by behavioral enrichment. Reversal learning was improved by both behavioral enrichment and dietary fortification. By contrast, the fortified food had no effect on the young dogs. These results suggest that behavioral enrichment or dietary fortification with antioxidants over a long-duration can slow age-dependent cognitive decline, and that the two treatments together are more effective than either alone in older dogs.

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Effects of early spatial training on water maze performance: a longitudinal study in mice

Cited by 40 publications

References 27 publications

Methylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine

Methylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine

Cognitive performance is highly sensitive to prior experience in mice with a learning and memory deficit: Failure leads to more failure

Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study

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