Effects of econazole nitrate on yeast cells and mitochondria

Correlation between the sterol composition of membranes and morphology inCandida albicans

“…The interaction of imidazoles with the plasma membrane, and the leakiness this induces, may explain the fungicidal properties of the drugs at high concentrations. Other effects of imidazoles include an inhibition of mitochondrial enzyme synthesis and activity [ 15,25] and, at lower concentrations, an inhibition of sterol biosynthesis. The effect on sterol biosynthesis is thought to be brought about by an inhibition of C-14 demethylation due to an interaction of the imidazole heterocycle with cytochrome P450- [18].…”

Antifungal agents of use in animal health – chemical, biochemical and pharmacological aspects

“…An increase in palmitate was also found in C. albicans grown in the presence of 1 µ M clotrimazole, econazole, miconazole or ketoconazole (Georgopapadakou et al ., 1987). As expected from the important role of ergosterol in mitochondrial activities, inhibition of ergosterol synthesis by, for example, miconazole (De Nollin et al ., 1977) and econazole (Wilm & Stahl, 1983) affects cytochrome c oxidase in the mitochondrial membranes of C. albicans and S. cerevisiae . Chitin is a structural component of fungal cell walls (see Kollar et al ., 1995).…”

Action of econazole on Ca2+ levels and cytotoxicity in OC2 human oral cancer cells

“…Econazole did not inhibit the activities of mitochondrial enzymes, but suppressed the synthesis of mitochondrial enzymes. 4 Biochemically, econazole inhibited C. albicans 5 and suppressed ATP levels in the fungus. 6 In vivo, econazole was used to treat dermatophytoses and cutaneous candidiasis in guinea pigs, 7 candidiasis in the rat, 8 and ocular diseases in the rabbit.…”