Effects of EEG-vigilance regulation patterns on early perceptual processes in human visual cortex

Bekhtereva, Valeria; Sander, Christian; Forschack, Norman; Olbrich, Sebastian; Hegerl, Ulrich; Müller, Matthias

doi:10.1016/j.clinph.2013.06.019

Cited by 20 publications

(17 citation statements)

References 48 publications

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“…We also acknowledge that rs‐fMRI is conducted within a poorly controlled experimental setting, and that unspecific factors such as changes in vigilance may affect brain activity in cortical and subcortical areas (Olbrich et al ., ). However, vigilance regulation has only a moderate impact on visual attention, and these effects are not mirrored by task performance (Bekhtereva et al ., ). Moreover, we observed regionally specific changes, which may not be subject to vigilance fluctuations (Olbrich et al ., ).…”

Section: Discussionmentioning

confidence: 99%

Visual system integrity and cognition in early Huntington's disease

Sambataro

Vasić

Baldas

et al. 2014

Eur J of Neuroscience

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Posterior cortical volume changes and abnormal visuomotor performance are present in patients with Huntington's disease (HD). However, it is unclear whether posterior cortical volume loss contributes to abnormal neural activity, and whether activity changes predict cognitive dysfunction. Using magnetic resonance imaging (MRI), we investigated brain structure and visual network activity at rest in patients with early HD (n = 20) and healthy controls (n = 20). The symbol digit modalities test (SDMT) and subtests of the Visual Object and Space Perception Battery were completed offline. For functional MRI data, a group independent component analysis was used. Voxel-based morphometry was employed to assess regional brain atrophy, and 'biological parametric mapping' analyses were included to investigate the impact of atrophy on neural activity. Patients showed significantly worse visuomotor and visual object performance than controls. Structural analyses confirmed occipitotemporal atrophy. In patients and controls, two spatiotemporally distinct visual systems were identified. Patients showed decreased activity in the left fusiform cortex, and increased left cerebellar activity. These findings remained stable after correction for brain atrophy. Lower fusiform cortex activity was associated with lower SDMT performance and with higher disease burden scores. These associations were absent when cerebellar function was related to task performance and disease burden. The results of this study suggest that regionally specific functional abnormalities of the visual system can account for the worse visuomotor cognition in HD patients. However, occipital volume changes cannot sufficiently explain abnormal neural function in these patient

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Section: Discussionmentioning

confidence: 99%

Visual system integrity and cognition in early Huntington's disease

Sambataro

Vasić

Baldas

et al. 2014

Eur J of Neuroscience

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“…1 ) improves upon earlier versions of the algorithm which have been validated performing simultaneous EEG-functional MRI [50] as well as simultaneous EEG-PET studies [54] and by relating the vigilance stages to different behavioural and autonomic parameters [51,[55][56][57] . These basic research studies also imply clinical relevance given the importance of cognitive tests, MRI and PET in diagnostic procedures, where VIGALL might contribute to improve diagnostic accuracy by assessing arousal-induced error variance.…”

Section: Application Of Vigallmentioning

confidence: 99%

Assessment of Wakefulness and Brain Arousal Regulation in Psychiatric Research

Sander¹,

Hensch²,

Wittekind³

et al. 2015

Neuropsychobiology

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tion of wakefulness to the environmental and situational needs so that the optimal balance between energy conservation and responsiveness can be obtained. Since one approach to the assessment of brain arousal regulation is the classification of EEG vigilance stages, a computer-based algorithm (Vigilance Algorithm Leipzig) has been introduced, allowing classification of EEG vigilance stages in EEG recordings under resting conditions. The time course of EEG vigilance stages in EEGs of 15-20 min duration allows estimation of the individual arousal regulation (hyperstable, adaptive, or unstable vigilance pattern). The vigilance model of affective disorders and attention-deficit/hyperactivity disorder links a disturbed arousal regulation to the pathogenesis of psychiatric disorders and accordingly helps to explain and possibly also predict treatment effects of pharmacological and nonpharmacological interventions for these conditions. AbstractDuring the last few decades, much knowledge has been gained about sleep being a heterogeneous condition with several distinct sleep stages that represent fundamentally different physiological states. The same applies for the wake state which also comprises distinct global functional states (called vigilance stages). However, various terms and concepts have been introduced describing different aspects of wakefulness, and accordingly several methods of assessment exist, e.g. sleep laboratory assessments (Multiple Sleep Latency Test, Maintenance of Wakefulness Test), questionnaires (Epworth Sleepiness Scale, Karolinska Sleepiness Scale), behavioural tasks (Psychomotor Vigilance Test) or electroencephalography (EEG)-based assessments (Alpha Attenuation Test, Karolinska Drowsiness Test). Furthermore, several theoretical concepts about the regulation of sleep and wakefulness have been put forward, and physiological correlates have been identified. Most relevant for healthy functioning is the regulation of brain arousal and the adap-

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“…Recent studies have convincingly shown that the IAF is very reliable in rest condition EEG recording (Grandy et al, 2013a,b; Tenke et al, 2013). Anyway, more caution has been suggested when the subjects in study have to perform some specific tasks (Bekhtereva et al, 2013). The TF marks the TF between the theta and alpha bands, and represents an estimate of the frequency at which the theta and alpha spectra intersect.…”

Section: Methodsmentioning

confidence: 99%

“…In addition, a cortical surface-based atlas has been defined based on average folding patterns mapped to a sphere and surfaces from individuals can be aligned with this atlas with a high-dimensional nonlinear registration algorithm. The surface-based pipeline consists of several stages previous described in detail (Ségonne et al, 2004; Bekhtereva et al, 2013). …”

Section: Methodsmentioning

confidence: 99%

EEG upper/low alpha frequency power ratio relates to temporo-parietal brain atrophy and memory performances in mild cognitive impairment

Moretti

Paternicò

Binetti

et al. 2013

Front. Aging Neurosci.

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Objective: Temporo-parietal cortex thinning is associated to mild cognitive impairment (MCI) due to Alzheimer disease (AD). The increase of EEG upper/low alpha power ratio has been associated with AD-converter MCI subjects. We investigated the association of alpha3/alpha2 ratio with patterns of cortical thickness in MCI.Materials and Methods: Seventy-four adult subjects with MCI underwent clinical and neuropsychological evaluation, electroencephalogram (EEG) recording and high resolution 3D magnetic resonance imaging. Alpha3/alpha2 power ratio as well as cortical thickness was computed for each subject. Three MCI groups were detected according to increasing tertile values of upper/low alpha power ratio. Difference of cortical thickness among the groups was estimated. Pearson’s r was used to assess the topography of the correlation between cortical thinning and memory impairment.Results: High upper/low alpha power ratio group had total cortical gray matter volume reduction of 471 mm2 than low upper/low alpha power ratio group (p < 0.001). Upper/low alpha group showed a similar but less marked pattern (160 mm2) of cortical thinning when compared to middle upper/low alpha power ratio group (p < 0.001). Moreover, high upper/low alpha group had wider cortical thinning than other groups, mapped to the Supramarginal and Precuneus bilaterally. Finally, in high upper/low alpha group temporo-parietal cortical thickness was correlated to memory performance. No significant cortical thickness differences was found between middle and low alpha3/alpha2 power ratio groups.Conclusion: High EEG upper/low alpha power ratio was associated with temporo-parietal cortical thinning and memory impairment in MCI subjects. The combination of EEG upper/low alpha ratio and cortical thickness measure could be useful for identifying individuals at risk for progression to AD dementia and may be of value in clinical context.

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Effects of EEG-vigilance regulation patterns on early perceptual processes in human visual cortex

Cited by 20 publications

References 48 publications

Visual system integrity and cognition in early Huntington's disease

Visual system integrity and cognition in early Huntington's disease

Assessment of Wakefulness and Brain Arousal Regulation in Psychiatric Research

EEG upper/low alpha frequency power ratio relates to temporo-parietal brain atrophy and memory performances in mild cognitive impairment

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