Effects of EGF on apoptosis of adipose derived stem cells by regulating miRNA-21

Liu, Ying; Chen, Xi; Qiang, Shuai; Lin, Qiushi; He, Fuliang; Dong, Xiaoqun; Xiao, Zhibo

doi:10.1016/j.wndm.2016.02.002

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…203 The micro-RNA21 in ADSCs has been found to be regulated by EGF, and addition of EGF can therefore increase proliferation and inhibit the apoptosis of ADSC. 204 These preliminary studies thus suggest that ADSCs improve retention capabilities of transplanted fat in a minimally invasive therapy for facial tissue deformity. The efficacy of ADSC-based adipose TE treatments, however, remains to be evaluated for safety and efficacy in large randomized double-blind controlled trials.…”

Section: Adipose Tissuementioning

confidence: 92%

Tissue Engineering and Regenerative Medicine in Craniofacial Reconstruction and Facial Aesthetics

Borrelli

Longaker

et al. 2020

Journal of Craniofacial Surgery

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The craniofacial region is anatomically complex and is of critical functional and cosmetic importance, making reconstruction challenging. The limitations of current surgical options highlight the importance of developing new strategies to restore the form, function, and esthetics of missing or damaged soft tissue and skeletal tissue in the face and cranium. Regenerative medicine (RM) is an expanding field which combines the principles of tissue engineering (TE) and self-healing in the regeneration of cells, tissues, and organs, to restore their impaired function. RM offers many advantages over current treatments as tissue can be engineered for specific defects, using an unlimited supply of bioengineered resources, and does not require immunosuppression. In the craniofacial region, TE and RM are being increasingly used in preclinical and clinical studies to reconstruct bone, cartilage, soft tissue, nerves, and blood vessels. This review outlines the current progress that has been made toward the engineering of these tissues for craniofacial reconstruction and facial esthetics.

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Section: Adipose Tissuementioning

confidence: 92%

Tissue Engineering and Regenerative Medicine in Craniofacial Reconstruction and Facial Aesthetics

Borrelli

Longaker

et al. 2020

Journal of Craniofacial Surgery

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Conversion of Adipose-Derived Stem Cells into Sweat Gland-Like Cells: An In Vitro Phenotypic Study

Qiang

Zhang

Liu

et al. 2020

Int J Dermatol Venereol

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Objective: This study was performed to explore the conversion of adipose-derived stem cells (ADSCs) into sweat gland-like cells for the purpose of sweat gland regeneration. Methods: ADSCs and human sweat gland (hSG) cells were isolated, cultured, and identified. The ADSCs were then cultured in combination with epidermal growth factor and/or cocultured with hSG cells in a Transwell coculturing system to transform the ADSCs into hSG-like cells. Phenotypic changes of the ADSCs were examined by morphological observation and immunocytochemical analysis of specific markers. Results: The ADSCs showed sweat gland-like morphologic changes and expressed sweat gland markers (cytokeratins 7, 14, and 18). Conclusion: These findings revealed that ADSCs can differentiate into hSG-like cells after coculture in a Transwell system and that epidermal growth factor can enhance the efficiency of differentiation. ADSCs may serve as a potential source of cells for sweat gland regeneration.

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Effects of EGF on apoptosis of adipose derived stem cells by regulating miRNA-21

Cited by 2 publications

References 31 publications

Tissue Engineering and Regenerative Medicine in Craniofacial Reconstruction and Facial Aesthetics

Tissue Engineering and Regenerative Medicine in Craniofacial Reconstruction and Facial Aesthetics

Conversion of Adipose-Derived Stem Cells into Sweat Gland-Like Cells: An In Vitro Phenotypic Study

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