Effects of Eight Weeks of Aerobic Exercises on the Cardiac Function and Inflammatory Markers of Male Patients with Heart Failure After Coronary Artery Bypass Grafting

Abstract

Background: Cardiovascular diseases are the leading cause of mortality across the world. Coronary artery bypass grafting (CABG) is frequently performed on patients with cardiac diseases, the outcomes of which are closely associated with lifestyle modification, especially physical exercise. Objectives: The present study aimed to evaluate the impact of aerobic exercises on the cardiac function and inflammatory markers of male patients with heart failure after CABG. Methods: This clinical trial was conducted on 20 male patients with heart failure after CABG, who were randomly divided into the intervention and control groups (10 per each). In total, 24 aerobic exercise sessions were performed in the form of three 60-minutes weekly sessions with 60% -70% maximal heart rate (MaxHR). Cardiac function was evaluated, and the levels of interleukin 6 (IL-6) high-sensitivity C-reactive protein (hsCRP) were measured before and after the intervention. Data analysis was performed in the PRISM software using independent and Paired t-test. Results: After the intervention, left ventricular ejection fraction significantly increased in the intervention group, while no changes were observed in the control group (P = 0.0039). However, no significant changes were observed in the diastolic function of the groups after the intervention (P > 0.05). IL-6 had no significant changes in the control group, while it significantly reduced in the intervention group (P = 0.002). Furthermore, the hsCRP significantly decreased in the intervention group (P = 0.036), while no significant changes were observed in the control group in this regard (P < 0.05). Conclusions: According to the results, aerobic exercises could improve systolic cardiac function and decrease IL-6 and hsCRP in the patients with cardiac failure. Therefore, these exercises are recommended following CABG.

Exercise engagement drives changes in cognition and cardiorespiratory fitness after 8 weeks of aerobic training in sedentary aging adults at risk of cognitive decline

“…While it is generally accepted that the minimum amount of time that is considered necessary for exercise to promote measurable improvements in cardiorespiratory performance is approximately 3 months ( 42 ), our exercise program length is consistent with other studies that have demonstrated 8 weeks to be sufficient to show positive changes in cardiorespiratory fitness and function ( 43 , 44 ). Our findings of an improvement in HRR in as little as 4 weeks of moderate intensity exercise are encouraging and suggest that HRR may capture cardiorespiratory improvements that are relevant for exercise-induced cognitive gains.…”

Comparison of Combined Aerobic-Resistance and Aerobic Training on Heart Systolic Function in Heart Failure Patients After Coronary Artery Bypass Graft Surgery (CABG)

“…In Iran, heart diseases are among the most important causes of death. According to the statistics of the Iranian Ministry of Health, more than 46% of deaths in Iran are due to this disease (3). Cardiac patients should be continuously cared for, and cardiac rehabilitation within the framework of regular exercise acts as an essential component of a comprehensive secondary prevention program that can reduce cardiac mortality by 25 -50% (4).…”

“…According to the statistics of the Iranian Ministry of Health, more than 46% of deaths in Iran are due to this disease (3). Cardiac patients should be continuously cared for, and cardiac rehabilitation within the framework of regular exercise acts as an essential component of a comprehensive secondary prevention program that can reduce cardiac mortality by 25 -50% (4). The rate of left ventricular ejection fraction is the most critical factor in the prognosis of patients after coronary artery bypass surgery (CABG), heart failure, especially systolic heart failure, and is an index by which the degree of failure is measured.…”

“…The rate of left ventricular ejection fraction is the most critical factor in the prognosis of patients after coronary artery bypass surgery (CABG), heart failure, especially systolic heart failure, and is an index by which the degree of failure is measured. The main goal of rehabilitation programs is to improve this index (4). Cardiac rehabilitation with targeted efforts focused on exercise, lipid control, hypertension control, and smoking cessation can reduce cardiovascular mortality (5).…”

“…Safi Khani et al (2012) reported that resistance and combined exercise had no significant effect on heart systolic function. However, Omidi et al reported that the development of aerobic exercises on the systolic part of the heart is practical, but they do not affect the diastolic function (3,11). Inconsistencies and little domestic research compare combined and aerobic exercise in heart failure patients following coronary artery bypass surgery.…”