Effects of Electroconvulsive Shock on the Serotonin Metabolism and Serotonin_1A Receptors in the Rat Brain

Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders

“…Increased density and sensitivity of the postsynaptic 5HT 1A receptors has been shown with antidepressant treatment and ECT, suggesting increased efficacy of the 5HT pathway [deMontigny and Aghajanian. 1978;Dijcks et al, 1991;Hayakawa et al, 1993]. Finally, decrease in 5HT reuptake transporter density and sensitivity has been shown with chronic antidepressant treatment [Lesch et al, 1993;Owens and Nemeroff, 1994;Pineyro et al, 1994], suggesting increased synaptic concentrations of 5HT.…”