Effects of Electrode Diameter and Contact Material on Signal Morphology of Gastric Bioelectrical Slow Wave Recordings

Kamat, Abhishek A; Paskaranandavadivel, Niranchan; Alighaleh, Saeed; Cheng, Leo K.; Angeli, Timothy R.

doi:10.1007/s10439-020-02457-5

Cited by 9 publications

(2 citation statements)

References 36 publications

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“…The electrode specifications such as the diameter and material of the electrode contacts affect the amplitude and SNR measurements (McAdams 2006). Materials such as silver and gold, which were utilized in the CNA and FPC arrays are unlikely to have a significant impact, but the difference in diameters (and thereby also contact areas) of the two arrays are likely to play a greater role (O'Grady et al 2009, Kamat et al 2020). The CNA electrodes were over four times smaller in diameter than the FPC electrodes (0.07 versus 0.3 mm) providing a plausible explanation for the 31% and 46% reduction in amplitude and SNR, respectively, noted during simultaneous serosal data collection via both the CNA and FPC arrays.…”

Section: Discussionmentioning

confidence: 99%

Transmural recordings of gastrointestinal electrical activity using a spatially-dense microelectrode array

et al. 2021

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Objective. High-resolution serosal recordings provide detailed information about the bioelectrical conduction patterns in the gastrointestinal (GI) tract. However, equivalent knowledge about the electrical activity through the GI tract wall remains largely unknown. This study aims to capture and quantify the bioelectrical activity across the wall of the GI tract. Approach. A needle-based microelectrode array was used to measure the bioelectrical activity across the GI wall in vivo. Quantitative and qualitative evaluations of transmural slow wave characteristics were carried out in comparison to the serosal slow wave features, through which the period, amplitude, and SNR metrics were quantified and statistically compared. Main results. Identical periods of 4.7 ± 0.3 s with amplitudes of 0.17 ± 0.04 mV versus 0.31 ± 0.1 mV and signal to noise ratios of 5.5 ± 1.3 dB versus 14.4 ± 1.1 dB were observed for transmural and serosal layers, respectively. Four different slow wave morphologies were observed across the transmural layers of the GI wall. Similar amplitudes were observed for all morphology types, and Type 1 and Type 2 were of the highest prevalence, dominating the outer and inner layers. Type 2 was exclusive to the middle layer while Type 4 was primarily observed in the middle layer as well. Significance. This study demonstrates the validity of new methodologies for measuring transmural slow wave activation in the GI wall and can now be applied to investigate the source and origin of GI dysrhythmias leading to dysmotility, and to validate novel therapeutics for GI health and disease.

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Section: Discussionmentioning

confidence: 99%

Transmural recordings of gastrointestinal electrical activity using a spatially-dense microelectrode array

et al. 2021

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“…Once the data were aligned, several parameters (Figure 1E) were calculated for each slow wave captured during the Reveal LINQ recording period. SNR was calculated using a previously reported method 29 To determine downstroke width and amplitude, the peak and trough of each downstroke were estimated using a zero‐crossing technique described previously 30 . The first derivative of the signal was calculated using a two‐point central difference scheme, and the closest zero‐crossing positions on either side of the AT were taken as the index of the peak and trough.…”

Section: Methodsmentioning

confidence: 99%

Translation of an existing implantable cardiac monitoring device for measurement of gastric electrical slow‐wave activity

Dowrick,

Jungbauer Nikolas,

Offutt

et al. 2023

Neurogastroenterology Motil

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BackgroundDespite evidence that slow‐wave dysrhythmia in the stomach is associated with clinical conditions such as gastroparesis and functional dyspepsia, there is still no widely available device for long‐term monitoring of gastric electrical signals. Actionable biomarkers of gastrointestinal health are critically needed, and an implantable slow‐wave monitoring device could aid in the establishment of causal relationships between symptoms and gastric electrophysiology. Recent developments in the area of wireless implantable gastric monitors demonstrate potential, but additional work and validation are required before this potential can be realized.MethodsWe hypothesized that translating an existing implantable cardiac monitoring device, the Reveal LINQ™ (Medtronic), would present a more immediate solution. Following ethical approval and laparotomy in anesthetized pigs (n = 7), a Reveal LINQ was placed on the serosal surface of the stomach, immediately adjacent to a validated flexible‐printed‐circuit (FPC) electrical mapping array. Data were recorded for periods of 7.5 min, and the resultant signal characteristics from the FPC array and Reveal LINQ were compared.Key ResultsThe Reveal LINQ device recorded slow waves in 6/7 subjects with a comparable period (p = 0.69), signal‐to‐noise ratio (p = 0.58), and downstroke width (p = 0.98) to the FPC, but with reduced amplitude (p = 0.024). Qualitatively, the Reveal LINQ slow‐wave signal lacked the prolonged repolarization phase present in the FPC signals.Conclusions & InferencesThese findings suggest that existing cardiac monitors may offer an efficient solution for the long‐term monitoring of slow waves. Translation toward implantation now awaits.

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Endoscopic mapping of bioelectric slow waves in the gastric antrum

Tremain,

Chan,

Rowbotham

et al. 2024

Device

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Effects of Electrode Diameter and Contact Material on Signal Morphology of Gastric Bioelectrical Slow Wave Recordings

Cited by 9 publications

References 36 publications

Transmural recordings of gastrointestinal electrical activity using a spatially-dense microelectrode array

Transmural recordings of gastrointestinal electrical activity using a spatially-dense microelectrode array

Translation of an existing implantable cardiac monitoring device for measurement of gastric electrical slow‐wave activity

Endoscopic mapping of bioelectric slow waves in the gastric antrum

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