2020
DOI: 10.1186/s13287-020-01954-7
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Effects of electromagnetic fields treatment on rat critical-sized calvarial defects with a 3D-printed composite scaffold

Abstract: Background Current strategies for craniofacial defect are faced with unmet outcome. Combining 3D-printing with safe, noninvasive magnetic therapy could be a promising breakthrough. Methods In this study, polylactic acid/hydroxyapatite (PLA/HA) composite scaffold was fabricated. After seeding rat bone marrow mesenchymal stem cells (BMSCs) on scaffolds, the effects of electromagnetic fields (EMF) on the proliferation and osteogenic differentiation capacity of BMSCs were investigated. Additionally, 6-mm critica… Show more

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Cited by 25 publications
(18 citation statements)
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“…The main goal of the addition of growth factors is to promote osteogenesis and angiogenesis. Our previous studies have shown that low-frequency sinusoidal electromagnetic fields have the ability to promote osteogenesis and angiogenesis of BMSCs [ 30 ]. So the sinusoidal electromagnetic fields as a safe and noninvasive physical intervention is likely to be a substitute for growth factors in the future.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The main goal of the addition of growth factors is to promote osteogenesis and angiogenesis. Our previous studies have shown that low-frequency sinusoidal electromagnetic fields have the ability to promote osteogenesis and angiogenesis of BMSCs [ 30 ]. So the sinusoidal electromagnetic fields as a safe and noninvasive physical intervention is likely to be a substitute for growth factors in the future.…”
Section: Discussionmentioning
confidence: 99%
“…The EMF stimulation system (Fig. 1 g) that has been introduced in our previous reports is made up of a EMF generator, an amplifier, an oscilloscope, and a pair of Helmhotz coil [ 28 30 ]. It was designed and manufactured by the Naval University of Engineering (Wuhan, China).…”
Section: Methodsmentioning
confidence: 99%
“…The CMF defect models discussed in this review are the calvarial, mandibular and orbital floor defect models. In most cases, a trephine 119–152 is used to create cylindrical defects in the calvaria and the mandible. Other bone cutting devices for cylindrical defects include a circular knife, 153 a biopsy punch, 154 a drill 126,155–159 and rongeurs 160 .…”
Section: Towards Clinically Driven Animal Modelsmentioning
confidence: 99%
“…Mechanical testing of regenerated areas is also used as an evaluation strategy (6 out of 66). To quantify the amount of repaired bone from histological and/or immunohistochemical analysis, either image analysis software is used (mostly ImageJ, 92,125,127,132,142,143,150,161,167–169 Image‐Pro Plus 119,122,157,170–172 or i‐solution 120,133,136 ), or a scoring system 173 is applied. Approximately 50% of studies do not show quantification of the histological and immunohistochemical images leading to potential biased and subjective analyses.…”
Section: Towards Clinically Driven Animal Modelsmentioning
confidence: 99%
“…Therefore, in this research, a 3D-printed scaffold loaded with BMSCs stimulated by low-frequency sinusoidal electromagnetic fields (15 Hz, 0.3 mT) was utilized to repair bone defects, and its role in bone repair was examined in detail. The selection of EMF parameters was based on the previous research by our team [ 23 – 25 ].…”
Section: Introductionmentioning
confidence: 99%