Effects of emodin on cell apoptosis of intestinal mucosa and serum leptin in rats with severe acute pancreatitis

Ning, Jian-Wen; Ji, Feng; Luo, Dandong; Chen, Yang; Wang, Lijun

doi:10.3736/jcim20091215

Cited by 7 publications

(8 citation statements)

References 10 publications

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“…Emodin has a protective effect in pancreatitis-associated secondary organ damage (Wang et al, 2007; Ning et al, 2009; Xia et al, 2010; Xu et al, 2016), which is both a common serious SAP complication and a main cause of death. Pancreatitis-associated lung injury occurs as a consequence of significant pulmonary hyperemia, edema, and inflammatory infiltration in the lung tissues.…”

Section: Pleiotropic Natural Productsmentioning

confidence: 99%

“…Emodin attenuates pulmonary edema and enhances alveolar epithelial barrier function by up-regulating the expression of claudin-4, claudin-5, occludin, AQP1, and AQP5 in lung tissue samples from rats with SAP-induced ALI (Xia et al, 2010; Xu et al, 2016). Several in vivo investigations have proposed that emodin can prevent the translocation of bacteria and endotoxins and promote the recovery of intestinal barrier function via inhibiting the intestinal mucosa cell apoptosis and up-regulating the serum leptin content (Ning et al, 2009). In addition, emodin-assisted early enteral nutrition (EAEEN) obviously abates the severity of secondary hepatic injury to function in the treatment of AP (Wang et al, 2007).…”

Section: Pleiotropic Natural Productsmentioning

confidence: 99%

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Chinese Herbal Medicines Attenuate Acute Pancreatitis: Pharmacological Activities and Mechanisms

Xiang

Zhang

et al. 2017

Front. Pharmacol.

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Acute pancreatitis (AP) is a commonly occurring gastrointestinal disorder. An increase in the annual incidence of AP has been observed, and it causes acute hospitalization and high mortality. The diagnosis and treatment guidelines for AP recommend conservative medical treatments focused on reducing pancreatic secretion and secondary injury, as a primary therapeutic approach. Unfortunately, the existing treatment options have limited impact on the incidence and severity of AP due to the complex and multifaceted pathological process of this disease. In recent decades, Chinese herbal medicines (CHMs) have been used as efficient therapeutic agents to attenuate AP in Asian countries. Despite early cell culture, animal models, and clinical trials, CHMs are capable of interacting with numerous molecular targets participating in the pathogenesis of AP; however, comprehensive, up-to-date communication in this field is not yet available. This review focuses on the pharmacological activities of CHMs against AP in vitro and in vivo and the underlying mechanisms. A computational prediction of few selected and promising plant-derived molecules (emodin, baicalin, resveratrol, curcumin, ligustrazine, and honokiol) to target numerous proteins or networks involved in AP was initially established based on a network pharmacology simulation. Moreover, we also summarized some potential toxic natural products for pancreas in order to more safe and reasonable medication. These breakthrough findings may have important implications for innovative drug research and the future development of treatments for AP.

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Section: Pleiotropic Natural Productsmentioning

confidence: 99%

Section: Pleiotropic Natural Productsmentioning

confidence: 99%

Chinese Herbal Medicines Attenuate Acute Pancreatitis: Pharmacological Activities and Mechanisms

Xiang

Zhang

et al. 2017

Front. Pharmacol.

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“…Systemic Effects . On animal models of AP, emodin prevented multiorgan failure [ 167 ], reduced the general severity of the disease (diminished mortality [ 103 , 114 , 115 ] and endotoxin and lactate levels [ 115 ]) as well as the impact on other organs/territories { peritoneum (less ascites [ 103 , 114 , 115 ]), liver (lower ALT and AST [ 115 ], improved histological score [ 167 ]), lungs (milder pathological changes of acute lung injury (ALI) [ 44 , 104 , 111 , 167 ]), and bowel (less damage [ 167 ] correlated with better intestinal transit and lower inflammatory activators and mediators (NF- κ B-p65, TNF- α , IL-1 β ) [ 107 ], ameliorated intestinal flora [ 102 ], and improved survival and barrier function of intestinal mucosal cells [ 167 ] resulting in diminished passage of bacteria and endotoxin [ 112 ])}, an effect boosted by the association with EEN [ 115 ] or with baicalein/baicalin in the case of ascites [ 114 ] and pulmonary injury [ 44 ]. The protective effect against ALI (translated in less pulmonary edema and inflammation) seems to be associated with the increased lung expression of aquaporins (AQP) 1 and 5 (AQP1 in the alveolar capillary endothelial cells and AQP5 in the alveolar type I and II cells), transmembrane proteins dedicated to water transport, whose decrease is strongly coupled with the development of ALI and pulmonary edema) [ 111 ].…”

Section: Proapoptotic Phytochemicals With Protective Effects In Pamentioning

confidence: 99%

Phytoceuticals in Acute Pancreatitis: Targeting the Balance between Apoptosis and Necrosis

Găman

Dragoș

Vlad

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Despite recent advances in understanding the complex pathogenesis of pancreatitis, the management of the disease remains suboptimal. The use of phytoceuticals (plant-derived pleiotropic multitarget molecules) represents a new research trend in pancreatology. The purpose of this review is to discuss the phytoceuticals with pancreatoprotective potential in acute pancreatitis and whose efficacy is based, at least in part, on their capacity to modulate the acinar cell death. The phytochemicals selected, belonging to such diverse classes as polyphenols, flavonoids, lignans, anthraquinones, sesquiterpene lactones, nitriles, and alkaloids, target the balance between apoptosis and necrosis. Activation of apoptosis via various mechanisms (e.g., inhibition of X-linked inhibitor of apoptosis proteins by embelin, upregulation of FasL gene expression by resveratrol) and/or inhibition of necrosis seem to represent the essential key for decreasing the severity of the disease. Apart from targeting the apoptosis/necrosis balance, the phytochemicals displayed other specific protective activities: inhibition of inflammasome (e.g., rutin), suppression of neutrophil infiltration (e.g., ligustrazine, resveratrol), and antioxidant activity. Even though many of the selected phytoceuticals represent a promising therapeutic alternative, there is a shortage of human evidence, and further studies are required to provide solid basis to justify their use in the treatment of pancreatitis.

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“…In another report, emodin was found to protect the intestinal mucosa from apoptotic injury induced by SAP. Emodin remarkably suppressed the endotoxins, apoptotic index and Bax levels, whereas the level of leptin elevated proving that emodin can inhibit the cell death of intestinal mucosa and up‐regulate the serum leptin levels to protect the intestinal barrier (Ning et al , ). In another report, P‐selectin was reported to be involved in the protection by pharmacological intervention of emodin from MODS (liver, lungs and intestines) associated with SAP (Wan et al , ).…”

Section: Herbal Remedies Used For Treating Pancreatitismentioning

confidence: 99%

The Role of Plant-derived Products in Pancreatitis: Experimental and Clinical Evidence

et al. 2017

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Pancreatitis is a gastrointestinal disease with a worldwide sharp surge during the past decade. Pancreatitis includes acute and chronic subtypes, which are graded based on the amount of pancreatic inflammation. Phytoconstituents represent a promising class of therapeutic agents with wide acceptability not only based on folk practices but sound presence of pharmacological and molecular evidences. Growing research evidence indicates that different molecular mechanisms are involved in their protective effect. Many phytoremedies have been tried for the treatment of pancreatic injuries and have shown success in preclinical animal models of pancreatitis. The literature was largely collected through PubMed and Google scholar database. A large proportion of phytochemicals targets the inflammatory cascade and modulates the overtly acting redox balance among which nuclear factor kappa-light-chain-enhancer of activated B cells is the key molecule. Inhibition of apoptosis (artemisinin, embelin), inflammasome (withaferin A), neutrophil rolling (fucoidan), Ca release (caffeine), mitogen activated protein kinase (guggulsterone) and many other novel mechanisms apart from antioxidant effect have been postulated behind the protective effect of phytoconstituents. The present review deals to fill the gap of hitherto unavailable comprehensive review on various plant products screened for the treatment of pancreatitis. The possible mechanistic profile of these phytochemicals is summarized. Copyright © 2017 John Wiley & Sons, Ltd.

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Effects of emodin on cell apoptosis of intestinal mucosa and serum leptin in rats with severe acute pancreatitis

Abstract: Emodin can inhibit the apoptosis of intestinal mucosa cells and up-regulate the serum leptin content to protect the intestina1 barrier function and prevent the translocation of bacteria and endotoxin.

Cited by 7 publications

References 10 publications

Chinese Herbal Medicines Attenuate Acute Pancreatitis: Pharmacological Activities and Mechanisms

Chinese Herbal Medicines Attenuate Acute Pancreatitis: Pharmacological Activities and Mechanisms

Phytoceuticals in Acute Pancreatitis: Targeting the Balance between Apoptosis and Necrosis

The Role of Plant-derived Products in Pancreatitis: Experimental and Clinical Evidence

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