Effects of emulsified and non-emulsified palm tocotrienol on bone and joint health in ovariectomised rats with monosodium iodoacetate-induced osteoarthritis

Ekeuku, Sophia Ogechi; Nor Muhamad, Muhamed Lahtif; Aminuddin, Alya Aqilah; Ahmad, Fairus; Wong, Sok Kuan; Mark-Lee, Wun Fui; Chin, Kok-Yong

doi:10.1016/j.biopha.2023.115998

Biomedicine & Pharmacotherapy

2024

DOI: 10.1016/j.biopha.2023.115998

|View full text |Cite

Effects of emulsified and non-emulsified palm tocotrienol on bone and joint health in ovariectomised rats with monosodium iodoacetate-induced osteoarthritis

Sophia Ogechi Ekeuku,

Muhamed Lahtif Nor Muhamad,

Alya Aqilah Aminuddin

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite1

Independent1

Authors

Journals

Cited by 2 publications

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

An injectable CS-hydrogel incorporating TPGS for cartilage repair

Tu,

Jiang,

et al. 2024

Materials & Design

View full text Add to dashboard Cite

An injectable CS-hydrogel incorporating TPGS for cartilage repair

Tu,

Jiang,

et al. 2024

Materials & Design

View full text Add to dashboard Cite

Updates in the skeletal and joint protective effects of tocotrienol: a mini review

Chin

2024

Front. Endocrinol.

Self Cite

View full text Add to dashboard Cite

Osteoporosis and osteoarthritis continue to pose significant challenges to the aging population, with limited preventive options and pharmacological treatments often accompanied by side effects. Amidst ongoing efforts to discover new therapeutic agents, tocotrienols (TTs) have emerged as potential candidates. Derived from annatto bean and palm oil, TTs have demonstrated efficacy in improving skeletal and joint health in numerous animal models of bone loss and osteoarthritis. Mechanistic studies suggest that TTs exert their effects through antioxidant, anti-inflammatory, Wnt-suppressive, and mevalonate-modulating mechanisms in bone, as well as through self-repair mechanisms in chondrocytes. However, human clinical trials in this field remain scarce. In conclusion, TTs hold promise as agents for preventing osteoporosis and osteoarthritis, pending further evidence from human clinical trials.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Effects of emulsified and non-emulsified palm tocotrienol on bone and joint health in ovariectomised rats with monosodium iodoacetate-induced osteoarthritis

Cited by 2 publications

References 78 publications

An injectable CS-hydrogel incorporating TPGS for cartilage repair

An injectable CS-hydrogel incorporating TPGS for cartilage repair

Updates in the skeletal and joint protective effects of tocotrienol: a mini review

Contact Info

Product

Resources

About