Effects of Endogenous Androgens and Abdominal Fat Distribution on the Interrelationship Between Insulin and Non-Insulin-Mediated Glucose Uptake in Females

Ezeh, Uche; Pall, Marita; Mathur, Ruchi; Dey, Damini; Berman, Daniel S.; Chen, Ida Y.; Dumesic, Daniel A.; Azziz, Ricardo

doi:10.1210/jc.2012-2937

Cited by 36 publications

(28 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Since the metabolic signatures encompass features related to glucose/insulin metabolism, future studies should investigate closely the relationships between metabolism, visceral adiposity and glucose tolerance classes. Moreover, there is compelling evidence that relationships between abdominal fat distribution and insulin and non-insulin-mediated glucose uptake in females are dependent on endogenous androgens [62], whilst the global adiposity and thickness of intraperitoneal and mesenteric adipose tissue depots have been found increased in women with polycystic ovary syndrome [63]. It will be therefore key in future studies to comprehensively integrate endocrinopathy with metabonomics and other physiological parameters.…”

Section: Discussionmentioning

confidence: 99%

Topographical Body Fat Distribution Links to Amino Acid and Lipid Metabolism in Healthy Non-Obese Women

et al. 2013

View full text Add to dashboard Cite

Visceral adiposity is increasingly recognized as a key condition for the development of obesity related disorders, with the ratio between visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) reported as the best correlate of cardiometabolic risk. In this study, using a cohort of 40 obese females (age: 25–45 y, BMI: 28–40 kg/m2) under healthy clinical conditions and monitored over a 2 weeks period we examined the relationships between different body composition parameters, estimates of visceral adiposity and blood/urine metabolic profiles. Metabonomics and lipidomics analysis of blood plasma and urine were employed in combination with in vivo quantitation of body composition and abdominal fat distribution using iDXA and computerized tomography. Of the various visceral fat estimates, VAT/SAT and VAT/total abdominal fat ratios exhibited significant associations with regio-specific body lean and fat composition. The integration of these visceral fat estimates with metabolic profiles of blood and urine described a distinct amino acid, diacyl and ether phospholipid phenotype in women with higher visceral fat. Metabolites important in predicting visceral fat adiposity as assessed by Random forest analysis highlighted 7 most robust markers, including tyrosine, glutamine, PC-O 44∶6, PC-O 44∶4, PC-O 42∶4, PC-O 40∶4, and PC-O 40∶3 lipid species. Unexpectedly, the visceral fat associated inflammatory profiles were shown to be highly influenced by inter-days and between-subject variations. Nevertheless, the visceral fat associated amino acid and lipid signature is proposed to be further validated for future patient stratification and cardiometabolic health diagnostics.

show abstract

Section: Discussionmentioning

confidence: 99%

Topographical Body Fat Distribution Links to Amino Acid and Lipid Metabolism in Healthy Non-Obese Women

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Indeed, a chicken-and-egg situation exists between IR and hyperandrogenemia in PCOS, and several in vitro and in vivo studies have demonstrated an improvement in IR through androgen reduction (37,38,39). Additionally, in either pre-or postmenopausal normal women, a direct relationship between androgen levels and IR or DM risk has been determined (40,41). In women with PCOS, but also in controls, androgen levels gradually decrease through time, as has been shown in several studies (42,43,44,45) and confirmed in the present one.…”

Section: Figurementioning

confidence: 99%

Diverse impacts of aging on insulin resistance in lean and obese women with polycystic ovary syndrome: evidence from 1345 women with the syndrome

Livadas

Panidis

Diamanti-Kandarakis

2014

European Journal of Endocrinology

View full text Add to dashboard Cite

Background: Polycystic ovary syndrome (PCOS) represents a moving spectrum of hormonal to metabolic abnormalities, as women with the syndrome are aging. Hormonal abnormalities, anovulation, and hyperandrogenic signs were predominant during the early years of PCOS and fade away with the years. Metabolic abnormalities and insulin resistance (IR) remain throughout the PCOS life cycle; however, it is unclear as to how they change, as women with the syndrome are aging. Objective: To evaluate the changes in IR and its associations with clinical, biochemical, hormonal, and ultrasound findings in a large cohort of women with PCOS and controls, as they are aging. Design: A cross-sectional study was carried out to evaluate the diverse impacts of aging on IR. Setting: An outpatient clinic was chosen for the study. Participants: A total of 1345 women with PCOS (Rotterdam criteria) and 302 controls of Caucasian origin and Greek ethnicity comprised the study group. Main outcome and measures: The impact of age on IR, as calculated using homeostasis model assessment of IR (HOMA-IR) index, and several PCOS characteristics were evaluated. Results: In PCOS, age (K0.045G0.008) was negatively, and BMI positively (0.18G0.007) associated with HOMA-IR (R 2 Z0.36).

show abstract

“…Primary features of the syndrome include biochemical or clinical hyperandrogenism, ovulatory dysfunction and polycystic ovaries 2 . Other common features include insulin resistance, elevated circulating insulin, and metabolic dysfunction 3 , which may be mechanistically linked to weight gain and obesity in this population 4;5 . In PCOS, elevated insulin may contribute to excess adiposity by limiting fat mobilization and oxidation, thus making weight maintenance and weight loss a significant challenge.…”

Section: Introductionmentioning

confidence: 99%

Effects of a eucaloric reduced-carbohydrate diet on body composition and fat distribution in women with PCOS

et al. 2014

Self Cite

View full text Add to dashboard Cite

Objective To determine if consumption of a reduced-carbohydrate (CHO) diet would result in preferential loss of adipose tissue under eucaloric conditions, and whether changes in adiposity were associated with changes in postprandial insulin concentration. Methods In a crossover-diet intervention, 30 women with PCOS consumed a reduced-CHO diet (41:19:40%energy from CHO:protein:fat) for 8 weeks and a standard diet (55:18:27) for 8 weeks. Body composition by DXA and fat distribution by CT were assessed at baseline and following each diet phase. Insulin AUC was obtained from a solid meal test (SMT) during each diet phase. Results Participants lost 3.7% and 2.2% total fat following the reduced-CHO diet and STD diet, resp. (p<0.05 for difference between diets). The reduced-CHO diet induced a decrease in subcutaneous-abdominal, intra-abdominal, and thigh-intermuscular adipose tissue (−7.1%, −4.6%, and −11.5%, resp.), and the STD diet induced a decrease in total lean mass. Loss of fat mass following the reduced CHO diet arm was associated with lower insulin AUC (p<0.05) during the SMT. Conclusions In women with PCOS, consumption of a diet lower in CHO resulted in preferential loss of fat mass from metabolically harmful adipose depots, whereas a diet high in CHO appeared to promote repartitioning of lean mass to fat mass.

show abstract

Effects of Endogenous Androgens and Abdominal Fat Distribution on the Interrelationship Between Insulin and Non-Insulin-Mediated Glucose Uptake in Females

Abstract: The decreased IMGU in PCOS is not accompanied by a compensatory increase in NIMGU or associated with excessive VAT accumulation. Increased general obesity, SAT, and hyperandrogenism are primary predictors of the deterioration of NIMGU in PCOS.

Cited by 36 publications

References 35 publications

Topographical Body Fat Distribution Links to Amino Acid and Lipid Metabolism in Healthy Non-Obese Women

Topographical Body Fat Distribution Links to Amino Acid and Lipid Metabolism in Healthy Non-Obese Women

Diverse impacts of aging on insulin resistance in lean and obese women with polycystic ovary syndrome: evidence from 1345 women with the syndrome

Effects of a eucaloric reduced-carbohydrate diet on body composition and fat distribution in women with PCOS

Contact Info

Product

Resources

About