Effects of Endometrial Serpin‐Like Proteins on Immune Responses in Sheep

Skopets, Boris; Liu, Wenjun; Hansen, Peter J.

doi:10.1111/j.1600-0897.1995.tb01143.x

Cited by 20 publications

(18 citation statements)

References 31 publications

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“…Ewes that were immunized against ovalbumin (a T cell-dependent antigen) had significantly lower antibody titers when the antigen was mixed in adjuvant containing OvUS than when the antigen was mixed with a negative control protein. 11 These results are consistent with earlier observations that showed that uterine fluids inhibited T cell-dependent (but not T cell-independent) antibody production in mice. 7 It is possible that OvUS may not be able to block activation of the gd-T cells that are present in the uterus during late pregnancy.…”

Section: Immunoregulatory Activity Of Ovussupporting

confidence: 93%

Immunoregulatory Activity, Biochemistry, and Phylogeny of Ovine Uterine Serpin

Peltier¹,

Hansen²

2001

American J Rep Immunol

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OvUS inhibits a wide variety of immune responses, including mixed lymphocyte reaction, mitogen-stimulated lymphocyte proliferation, and T cell-dependent antibody production. Recent data have suggested that OvUS functions by inhibiting protein kinase C and interleukin-2-mediated events. OvUS and similar genes present in cattle and pigs diverged from other serpins prior to the divergence of artiodactyls. Since this time, the serpins have apparently undergone adaptive evolution that has led to a conformational state and biological functions distinct from prototypical serpins. Thus, it is likely that these proteins have an important role in the reproductive biology of Artiodactyla. Several lines of evidence suggest that, in sheep, OvUS functions to mediate the immunosuppressive effects of progesterone and prevent immunological rejection of the fetal allograft.

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Section: Immunoregulatory Activity Of Ovussupporting

confidence: 93%

Immunoregulatory Activity, Biochemistry, and Phylogeny of Ovine Uterine Serpin

Peltier¹,

Hansen²

2001

American J Rep Immunol

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“…PAGs can also bind relatively well to uterine serpins in vitro (Mathialagan & Hansen 1996). The uterine serpins have immunomodulatory activities and it is possible that the PAGs could be augmenting such actions (Skopets et al 1995, Liu et al 1999, Peltier et al 2000. Finally, it may be notable that polymorphonuclear neutrophil leukocyte activity and other immune cell activities in periparturient cows are lowest around parturition (Kehrli et al 1989, Saad et al 1989, Hansen 2013.…”

Section: Proposed Immunomodulatory Actions Of Pag1/pspbmentioning

confidence: 99%

Placental PAGs: gene origins, expression patterns, and use as markers of pregnancy

et al. 2015

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Pregnancy-associated glycoproteins (PAGs) are abundantly expressed products of the placenta of species within the Cetartiodactyla order (even-toed ungulates). They are restricted to this order and they are particularly numerous in the Bovidae. The PAGs exhibit a range of temporal and spatial expression patterns by the placental trophoblasts and probably represent a group of related proteins that perform a range of distinct functions in the epitheliochorial and synepitheliochorial placental forms. This review presents an overview of the origins of the PAGs, a summary of PAG expression patterns, and their use as markers of pregnancy status. Speculations about their putative role(s) in pregnancy are also presented.Reproduction (2015) 149 R115-R126

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“…A role of OvUS in inhibition of uterine immune responses is indicated by several observations. In vitro, OvUS inhibits lymphocyte activation and proliferation induced by T cell mitogens and interleukin-2 (Segerson et al, 1984;Skopets and Hansen, 1993;Skopets et al, 1995;Peltier et al, 2000) and natural killer cell activity (Liu and Hansen, 1993;Tekin and Hansen, 2002). In vivo, OvUS inhibits T-cell dependent antibody production in sheep (Skopets et al, 1995) and fetal loss induced by natural killer cell activation mediated by injection of poly(I) Á poly(C) (Liu and Hansen, 1993).…”

Section: Introductionmentioning

confidence: 99%

Actions of progesterone on uterine immunosuppression and endometrial gland development in the uterine gland knockout (UGKO) ewe

Padua

Teki̇n

Spencer

et al. 2005

Molecular Reproduction Devel

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In ewes, the uterine gland knockout (UGKO) phenotype is caused by neonatal exposure to norgestomet to arrest uterine gland development and produce an adult which has a uterus characterized by the lack of endometrial glands. Since endometrial glands in the sheep produce the lymphocyte-inhibitory protein, ovine uterine serpin (OvUS), an experiment was conducted with ewes of the UGKO phenotype to evaluate whether the inhibitory actions of progesterone on tissue rejection responses in utero are dependent upon the presence of endometrial glands. Control and UGKO ewes were ovariectomized and subsequently treated with either 100 mg/day progesterone or corn oil vehicle for 30 days. An autograft and allograft of skin were then placed in each uterine lumen and treatments were continued for an additional 30 days before grafts were examined for survival. All autografts survived and had a healthy appearance after histological analysis. Allografts were generally rejected in ewes treated with vehicle but were present for hormone-treated ewes, regardless of uterine phenotype. Analysis of the histoarchitecture and protein synthetic capacity of the uterus revealed that progesterone induced differentiation of endometrial glands and synthesis and secretion of OvUS in UGKO ewes. The UGKO ewes had reduced density of CD45R+ lymphocytes in the endometrial epithelium and there was a tendency for progesterone to reduce this effect in luminal epithelium. Taken together, results confirm the actions of progesterone to inhibit graft rejection response in utero. Responses of UGKO ewes to progesterone indicate that the hormone can induce de novo development and differentiation of endometrial glands, at least when skin grafts are in the uterus.

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Effects of Endometrial Serpin‐Like Proteins on Immune Responses in Sheep

Abstract: Results strengthen the thesis that UTMP are physiologically relevant immunoregulatory molecules. Nonetheless, effects on skin-fold responses indicate that actions of UTMP can be more complex than would be predicted based on the proteins only having a single biological effect.

Cited by 20 publications

References 31 publications

Immunoregulatory Activity, Biochemistry, and Phylogeny of Ovine Uterine Serpin

Immunoregulatory Activity, Biochemistry, and Phylogeny of Ovine Uterine Serpin

Placental PAGs: gene origins, expression patterns, and use as markers of pregnancy

Actions of progesterone on uterine immunosuppression and endometrial gland development in the uterine gland knockout (UGKO) ewe

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