Effects of Endoscopic Mucosal Resection in Patients with Low-Grade Intraepithelial Dysplasia of Esophageal Squamous Cells

Li, Hao; Cheng, Juan Li; Dong, Ning; Cui, Chun Yong; Diao, Tao Yu; Zhou, Xue Rui

doi:10.1159/000354577

Cited by 4 publications

(1 citation statement)

References 37 publications

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“…It has been reported that the progression of esophageal mucosa generally progresses through the stages of normal epithelium, mild atypical hyperplasia, moderate atypical hyperplasia, severe atypical hyperplasia, carcinoma in situ, invasive carcinoma, etc [ 21 ]. Although esophageal dysplasia does not require immediate endoscopic resection, surveillance should be maintained because of the potential risk of early esophageal cancer or precancerous lesions[ 22 - 24 ]. Early treatment of esophageal mucosal lesions is helpful for preventing progression to esophageal cancer.…”

Section: Discussionmentioning

confidence: 99%

Effect of vinegar supplementation on patients with esophageal lesions lightly stained with Lugol’s iodine solution: Prospective single-centre trial

Gao,

Ye,

et al. 2024

World J Gastrointest Endosc

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BACKGROUND Esophageal chromoendoscopy with iodine solution is important for detecting early esophageal cancer. The effect of routine treatment for lesions lightly stained with Lugol’s iodine solution is limited, and the addition of natural substances to a regular diet is becoming increasingly common. Vinegar has antitumor effects as reported in previous studies. AIM To evaluate whether vinegar supplementation could improve the prognosis of patients with lightly stained esophageal lesions. METHODS This prospective single-centre trial included consecutive patients with lightly stained lesions between June 2020 and April 2022. Patients in the experimental group received increased amounts of vinegar for 6 months. The primary outcome of the study was the clinical therapeutic effect. Complications related to vinegar ingestion and adverse events were also recorded in detail. RESULTS A total of 166 patients were included in the final analysis. There was no significant difference in the baseline data between the two groups. Intention-to-treat (ITT) analysis demonstrated that the rates at which endoscopic characteristics improved were 33.72% in the experimental group and 20.00% in the conventional group (P = 0.007); and the rates at which biopsy pathology improved were 19.77% and 8.75%, respectively (P = 0.011). Additional vinegar consumption had a statistically protective effect on the rate at which endoscopic characteristics improved [hazard ratio (HR) ITT = 2.183, 95%CI: 1.183-4.028; HRper-protocol (PP) = 2.307, 95%CI: 1.202-4.426] and biopsy pathology improved (HRITT = 2.931, 95%CI: 1.212-7.089; HRPP = 3.320, 95%CI: 1.295-8.507). No statistically significant effect of increased vinegar consumption on preventing high-grade intraepithelial neoplasia or early cancer was observed (HRITT = 0.382, 95%CI: 0.079-1.846; HRPP = 0.382, 95%CI: 0.079-1.846). The subgroup analyses indicated that the overall therapeutic improvement of endoscopic characteristics and biopsy pathology seemed more obvious in older (age > 60) male patients with small lesions (lesion size ≤ 0.5 cm). Three patients in the experimental group reported acid regurgitation and heartburn. No adverse event during gastroscopy were recorded during follow-up. CONCLUSION A moderately increased ingestion of vinegar could not directly reduce the risk of esophageal cancer in the mucosa dysplasia population, but it improved the endoscopic characteristics and ameliorated the biopsy pathology to a certain extent. Further research is needed to verify the effect of nutritional intervention on precancerous esophageal lesions.

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Section: Discussionmentioning

confidence: 99%

Effect of vinegar supplementation on patients with esophageal lesions lightly stained with Lugol’s iodine solution: Prospective single-centre trial

Gao,

Ye,

et al. 2024

World J Gastrointest Endosc

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Current status and perspectives of esophageal cancer: a comprehensive review

Jiang,

Zhang,

et al. 2024

Cancer Communications

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Esophageal cancer (EC) continues to be a significant global health concern, with two main subtypes: esophageal squamous cell carcinoma and esophageal adenocarcinoma. Prevention and changes in etiology, improvements in early detection, and refinements in the treatment have led to remarkable progress in the outcomes of EC patients in the past two decades. This seminar provides an in‐depth analysis of advances in the epidemiology, disease biology, screening, diagnosis, and treatment landscape of esophageal cancer, focusing on the ongoing debate surrounding multimodality therapy. Despite significant advancements, EC remains a deadly disease, underscoring the need for continued research into early detection methods, understanding the molecular mechanisms, and developing effective treatments.

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Effects of Endoscopic Mucosal Resection in Patients with Low-Grade Intraepithelial Dysplasia of Esophageal Squamous Cells

Cited by 4 publications

References 37 publications

Effect of vinegar supplementation on patients with esophageal lesions lightly stained with Lugol’s iodine solution: Prospective single-centre trial

Effect of vinegar supplementation on patients with esophageal lesions lightly stained with Lugol’s iodine solution: Prospective single-centre trial

Current status and perspectives of esophageal cancer: a comprehensive review

Diagnosis and therapy of esophageal squamous cell dysplasia and early esophageal squamous cell cancer

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