Effects of endosulfan, thiamethoxam, and indoxacarb in combination with atrazine on multi-biomarkers in Gammarus kischineffensis

Demirci, Özlem; Güven, Kemal; Asma, Dilek; Öğüt, Serdal; Uğurlu, Pelin

doi:10.1016/j.ecoenv.2017.09.038

Cited by 54 publications

(16 citation statements)

References 64 publications

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“…In their experiments, Demirci et al [7] observed that indoxacarb did not considerably affect the activity of SOD, CAT and GR in Ostrinia nubilalis larvae when compared to the control group, while the same enzymes, including GST, were considerably increased in the aquatic crustacean Gammarus kischineffensis. In contrast, in our experiments, ECB larvae treated with indoxacarb (T1) showed significantly lower activities of CAT and GR when compared to the group treated with chlorantraniliprole, while indoxacarb induced SOD to a considerably higher activity than the two other insecticides (T2 and T3).…”

Section: Discussionmentioning

confidence: 92%

“…In-doxacarb (Avaunt®) belongs to the oxadiazine insecticides that show high selectivity and efficacy against lepidopteran pests [6]. Because class of indoxacarb is a prooxidant, it has to be metabolized to the decarboxylated form to become biologically active [7]. By blocking the neuronal sodium channels, the activated indoxacarb metabolites cause irreversible paralysis and disable food intake, thereby causing insect death [8,9].…”

Section: Introductionmentioning

confidence: 99%

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Effects of different insecticides on the antioxidative defense system of the European Corn Borer (Ostrinia nubilalis Hübner) (Lepidoptera: Crambidae) larvae

Franeta

Mirčić

Todorović

et al. 2018

ARCH BIOL SCI BELGRA

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The European corn borer (Ostrinia nubilalis) is one of the most important insect pests of maize, and has a significant impact on the production of this crop. In this work, we examined the effects of different insecticides on the antioxidative defense system of O. nubilalis larvae. The experimental setup consisted of a completely randomized block design with 4 replicates. Four experimental groups were formed as follows: control (C), indoxacarb (250 mL ha-1), chlorantraniliprole (100 mL ha-1) and the chlorantraniliprole+lambda cyhalothrin (200 mL ha-1) group. Larvae from maize stems were collected 20 days after insecticide application and the whole larvae were homogenized. The activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione S-transferase (GST), and the total amount of free SH groups were assessed. Comparison of the experimental groups showed that indoxacarb significantly affected the activities of GST, GPx and the total amount of free SH groups, while chlorantraniliprole significantly affected the activities of SOD, CAT, GST and the total amount of free SH groups, while chlorantraniliprole+lambda cyhalothrin significantly affected the activities of CAT, GST and the total amount of free SH groups. The results show that exposure to insecticides considerably affects the antioxidative defense components of the European corn borer larvae, especially chlorantraniliprole (T2).

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Effects of different insecticides on the antioxidative defense system of the European Corn Borer (Ostrinia nubilalis Hübner) (Lepidoptera: Crambidae) larvae

Franeta

Mirčić

Todorović

et al. 2018

ARCH BIOL SCI BELGRA

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“…We emphasize that testing conditions are important for an accurate determination of LC50 or T50 values, which in turn can influence the calculation of n values in the model regression. For example, acute tests (4 days) with thiamethoxam on the amphipod Gammarus kischineffensis showed a clear time-cumulative pattern (n = 2.41) due to the excellent fit to the estimated LC50 values (r 2 = 1.0) [40], whereas the same compound tested on the same species under different conditions showed n = 0.80, which is close to following Haber's rule [43]. The latter test, however, showed poorer goodness of fit to the data (r 2 = 0.87) than the former one.…”

Section: Aquatic Organismsmentioning

confidence: 52%

“…Nevertheless, given the good fit of the model to the dataset (r 2 = 0.85) this result cannot be excluded. Examples of time-cumulative toxicity for three chemicals are shown in Figure 3a,b. clothianidin on the predatory bug Cyrtorhinus lividipennis and the brown hopper pest species indicate values of n = 3.7 and 4.5, respectively [42]; imidacloprid on the ant Linepithema humile (n = 3.5) [43], on the termite Reticulitermes flavipes (n = 4.0) [44] and on the honeybee (n = 5.8) [45]. The latter value of n is unusually high, suggesting that the bees tested may have died by an interaction of the insecticide with other factors such as pathogenic infections or others.…”

Section: Terrestrial Organismsmentioning

confidence: 99%

Time-Cumulative Toxicity of Neonicotinoids: Experimental Evidence and Implications for Environmental Risk Assessments

Sánchez‐Bayo

Tennekes²

2020

IJERPH

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Our mechanistic understanding of the toxicity of chemicals that target biochemical and/or physiological pathways, such as pesticides and medical drugs is that they do so by binding to specific molecules. The nature of the latter molecules (e.g., enzymes, receptors, DNA, proteins, etc.) and the strength of the binding to such chemicals elicit a toxic effect in organisms, which magnitude depends on the doses exposed to within a given timeframe. While dose and time of exposure are critical factors determining the toxicity of pesticides, different types of chemicals behave differently. Experimental evidence demonstrates that the toxicity of neonicotinoids increases with exposure time as much as with the dose, and therefore it has been described as time-cumulative toxicity. Examples for aquatic and terrestrial organisms are shown here. This pattern of toxicity, also found among carcinogenic compounds and other toxicants, has been ignored in ecotoxicology and risk assessments for a long time. The implications of the time-cumulative toxicity of neonicotinoids on non-target organisms of aquatic and terrestrial environments are far reaching. Firstly, neonicotinoids are incompatible with integrated pest management (IPM) approaches and secondly regulatory assessments for this class of compounds cannot be based solely on exposure doses but need also to take into consideration the time factor.

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“…In other fish species, sub-chronic exposure to low atrazine increased CAT and SOD activities (56,59), whereas acute exposure generally lowered CAT, GPx, and SOD activities (55,57,58), with exception of neotropical fish, which showed no change (56). Furthermore, in two studies atrazine exposure of Gammarus kischineffensis and shrimp Palaemonetes argentinus resulted in lower CAT but higher SOD activity (61,62).…”

Section: Involvement Of Oxidative Stress In Atrazine Toxicitymentioning

confidence: 91%

Oxidative stress in triazine pesticide toxicity: a review of the main biomarker findings

Semren

Žunec

Pizent

2018

Archives of Industrial Hygiene and Toxicology

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This review article provides a summary of the studies relying on oxidative stress biomarkers (lipid peroxidation and antioxidant enzymes in particular) to investigate the effects of atrazine and terbuthylazine exposure in experimental animals and humans published since 2010. In general, experimental animals showed that atrazine and terbuthylazine exposure mostly affected their antioxidant defences and, to a lesser extent, lipid peroxidation, but the effects varied by the species, sex, age, herbicide concentration, and duration of exposure. Most of the studies involved aquatic organisms as useful and sensitive bio-indicators of environmental pollution and important part of the food chain. In laboratory mice and rats changes in oxidative stress markers were visible only with exposure to high doses of atrazine. Recently, our group reported that low-dose terbuthylazine could also induce oxidative stress in Wistar rats. It is evident that any experimental assessment of pesticide toxic effects should take into account a combination of several oxidative stress and antioxidant defence biomarkers in various tissues and cell compartments. The identified effects in experimental models should then be complemented and validated by epidemiological studies. This is important if we wish to understand the impact of pesticides on human health and to establish safe limits.

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Effects of endosulfan, thiamethoxam, and indoxacarb in combination with atrazine on multi-biomarkers in Gammarus kischineffensis

Cited by 54 publications

References 64 publications

Effects of different insecticides on the antioxidative defense system of the European Corn Borer (Ostrinia nubilalis Hübner) (Lepidoptera: Crambidae) larvae

Effects of different insecticides on the antioxidative defense system of the European Corn Borer (Ostrinia nubilalis Hübner) (Lepidoptera: Crambidae) larvae

Time-Cumulative Toxicity of Neonicotinoids: Experimental Evidence and Implications for Environmental Risk Assessments

Oxidative stress in triazine pesticide toxicity: a review of the main biomarker findings

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