Effects of Enfonidipine Hydrochloride in Dogs with Experimental Supraventricular Tachyarrhythmia

Fukushima, Ryuji; Tanaka, Ryou; Matsumoto, Hirotaka; Motomura, Noboru; Hirose, Hisashi; Yamane, Yoshihisa; Koyama, Hidekazu

doi:10.1292/jvms.09-0358

Cited by 5 publications

(4 citation statements)

References 25 publications

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“…The Ao-PEP and Ao-ET were considered susceptible to the effects of the HR, and an increased HR reduced the Ao-PEP and Ao-ET, whereas a decreased HR reduced the Ao-PEP and Ao-ET [ 20 , 25 ]. Therefore, the ratio of Ao-PEP to Ao-ET (Ao-PEP/ET) has been used as an effective index for the clinical evaluation of ventricular contractility, as with FS [ 7 , 8 ]. No significant change was observed in the Ao-PEP/ET in this study, suggesting that the decreases in the Ao-PEP and Ao-ET resulted from an increase in the HR.…”

Section: Discussionmentioning

confidence: 99%

Effects of cilostazol on the heart rate in healthy dogs

Fukushima

Kawaguchi

Yamada

et al. 2018

The Journal of Veterinary Medical Science

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Appropriate dosages of cilostazol have not been studied in veterinary patients, and the degrees of heart rate (HR) increase have not been studied in dogs administered cilostazol. Therefore, this study aimed to investigate the degrees of HR increase in healthy dogs administered cilostazol. Thirty healthy beagle dogs (15 males and 15 females; age, 5–8 years) were divided into 3 groups of 10 dogs each and orally administered 2.5, 5, or 10 mg/kg cilostazol (twice a day at 8:00 AM and 8:00 PM for 10 days). Higher HR increases were seen in the 5 mg/kg group than in the 2.5 mg/kg group at all time points except 7:00 AM, 9:00 AM, 1:00 PM, and 4:00 PM (P<0.01). Higher HR increases were also observed in the 10 mg/kg group than in the 2.5 mg/kg group at all time points except 4:00 PM (P<0.01). The 10 mg/kg group showed higher HR increases than the 5 mg/kg group at all time points except 6:00 AM, 7:00 AM, 6:00 PM, and 7:00 PM (P<0.05 for 4:00 PM and 5:00 PM; P<0.01 for the other time points). These results together show that the HR of healthy dogs increased in a dose-dependent manner after cilostazol administration twice a day at doses of 5 to 10 mg/kg. These results provide a useful basis for choosing cilostazol in the treatment of bradyarrhythmia in dogs.

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Section: Discussionmentioning

confidence: 99%

Effects of cilostazol on the heart rate in healthy dogs

Fukushima

Kawaguchi

Yamada

et al. 2018

The Journal of Veterinary Medical Science

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“…Reduction of LAP is a desirable goal for drugs used to treat congestive heart failure in MVD. In general, calcium channel blockers are used for treatment of hypertrophic cardiomyopathy [5-7], atrial fibrillation [8-10], and systemic hypertension [11,12]. Amlodipine is a long acting 1,4-dihydropyridine calcium channel blocker, often used for treatment of systemic hypertension.…”

Section: Introductionmentioning

confidence: 99%

Comparative effects of amlodipine and benazepril on Left Atrial Pressure in Dogs with experimentally-induced Mitral Valve Regurgitation

et al. 2012

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BackgroundOne of the purposes of treatment for dogs with mitral regurgitation (MR) is lowering left atrial pressure (LAP). There has been few study of the amlodipine in dogs with MR and amlodipine’s effect on LAP has not been fully evaluated in a quantitative manner because of difficulties in directly measuring LAP. The objective of our study was to compare the short-term effects of amlodipine (0.2 mg/kg PO q12h) vs benazepril (0.5 mg/kg PO q12h), on LAP and echocardiographic parameters in five beagle dogs with experimentally-induced MR. LAP of eight dogs that has own control were measured using radiotelemetry system at baseline and again on days 1, 2, 3, 4, 5, 6, 7 of the drug administration.ResultsMean LAP decreased significantly after amlodipine (11.20 ± 4.19 mmHg vs 14.61 ± 3.81 mmHg at baseline, p < .01) but not after benazepril treatment (13.19 ± 3.47 mmHg, p > .05). LAP was lower after 7 days of amlodipine treatment than after 7 days of benazepril treatment. Significant reduction was seen for the first time 4 days after the administration amlodipine. The rate of the maximal area of the regurgitant jet signals to the left atrium area (ARJ/LAA) of the amlodipine treatment was significantly lower (p < .05) after 7 days compared to baseline. Other echocardiographic parameters did not change significantly.ConclusionsLAP was significantly decreased after amlodipine treatment in dogs with surgically-induced MR but not after benazepril treatment. Although this study did not focus on adverse effects, amlodipine may be an effective drug for helping the patients with acute onset of severe MR, such as rupture of chordae tendinae or end stage patients were the LAP is likely to be elevated. Additional studies in clinical patients with degenerative mitral valve disease and acute chordal rupture are warranted because the blood-pressure lowering effects of amlodipine can decrease renal perfusion and this can further activate the RAAS.

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“…Under general anesthesia, a pacing lead was implanted in the animals in accordance with the guidelines provided by Fukushima [9] and Gaspo et al [12]. In the present study, for stimulation of the atrium by RAP (2 mV, 390 bpm), artificial tachycardia was immediately triggered and maintained in the dog, and hemodynamics resembling the spontaneously developed similar to AF were obtained [9, 12] (Fig.…”

Section: Methodsmentioning

confidence: 83%

Comparison between blood coagulability in the intra-atrial and peripheral regions during the acute phase after rapid atrial pacing

et al. 2019

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The changes in intra-atrial blood coagulability of acute phase after development of atrial fibrillation (AF) have not been elucidated in human. In the present study, blood coagulability were examined in the intra-atrial and peripheral regions during the acute phase after development of rapid atrial pacing (RAP) in experimentally created model dog similar to AF, using Total Thrombus-formation Analysis System (T-TAS) that is capable of comprehensively evaluating thrombogenicity in the bloodstream in the microvascular channel. According to the results, both the coagulating function-evaluating time to +10 kPa (T 10 ) and occlusion time (OT) of the AR chip (chip for thrombus analysis mixed with coagulation and platelet) were significantly shortened in the atrial blood as early as 30 min after pacing (T 10 , 150.5 ± 40.5 s; OT, 212.4 ± 44.3 s) compared to the pre-pacing levels (T 10 , 194.5 ± 47.5 s; OT, 259.9 ± 49.5 s) ( P <0.05). The OT of PL chip (chip for platelet thrombus analysis) was significantly shortened 30 min after pacing (231.8 ± 57.6 s), compared to the pre-pacing level (289.5 ± 96.0 s) ( P <0.05). Meanwhile, none of T 10 and OT of AR and PL chips showed any significant changes in the peripheral blood. The study demonstrated increase of blood coagulability 30 min after development of RAP. While no significant changes were observed in the peripheral blood in the present study, the outcome suggested that the anti-thrombus treatments are better to be started early after AF even if coagulability of the peripheral blood shows no change.

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Effects of Enfonidipine Hydrochloride in Dogs with Experimental Supraventricular Tachyarrhythmia

Cited by 5 publications

References 25 publications

Effects of cilostazol on the heart rate in healthy dogs

Effects of cilostazol on the heart rate in healthy dogs

Comparative effects of amlodipine and benazepril on Left Atrial Pressure in Dogs with experimentally-induced Mitral Valve Regurgitation

Comparison between blood coagulability in the intra-atrial and peripheral regions during the acute phase after rapid atrial pacing

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