Effects of engrafted neural stem cells in Alzheimer's disease rats

Xuan, Aiguo; Luo, Meifeng; Ji, Wanqing; Long, Dahong

doi:10.1016/j.neulet.2008.12.001

Cited by 80 publications

(54 citation statements)

References 21 publications

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“…These factors play a neuroprotective role for motor neurons also physical exercise appeared to be beneficial in animal experiments [68][69][70][71].…”

Section: Neural Progenitor Cellsmentioning

confidence: 97%

Stem Cells for Neuro-regeneration: State of the Art

Wagih¹,

Elhawary²,

Ellessy³

et al. 2015

BIO

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Neuroregeneration (NR) is a long-sought medical dream which has intrigued vast research in the past decades. A traditional physiologic dogma that central nervous system does not regenerate has been strongly challenged in the recent years since the advent of the stem cell era. Stem cell research in the regenerative field passes through three main stages. The first stage is the in-vitro experiments which studies the exact molecular and cellular mechanisms underlying stem cell-mediated NR. The second stage is the application of these data in experimental animal settings to provide "proof of concept" of stem cell therapy in animal models. The final step is the translation of these data in pilot clinical trials. In this review, we will try to gather the different data of stem cell-mediated NR from various experimental and clinical researches.

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“…These factors play a neuroprotective role for motor neurons also physical exercise appeared to be beneficial in animal experiments [68][69][70][71].…”

Section: Neural Progenitor Cellsmentioning

confidence: 97%

Stem Cells for Neuro-regeneration: State of the Art

Wagih¹,

Elhawary²,

Ellessy³

et al. 2015

BIO

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“…The expression of BDNF was related to increases in cognitive function [47] and improved the effects of NSPCs at the same time [48] . Most importantly, transplanted NSPCs can differentiate into cholinergic neurons in a rat AD model [49] .…”

Section: Exogenous Stem Cellsmentioning

confidence: 99%

“…For the latter, several cell types have been shown to have the potential to differentiate into cholinergic cell phenotypes. Transplanted NSCs were shown to differentiate into cholinergic neurons in a rat AD model [49] . Transplantation of mouse ESC-derived neuronal precursor cells, following commitment to a cholinergic cell phenotype, was able to promote behavioral recovery in a rodent model of AD [31] .…”

Section: (3) Enhancing Endogenous Synaptogenesismentioning

confidence: 99%

Cell-based therapy in Alzheimer's disease: Current knowledge and perspective

Qiao

Huang²,

Chen

2016

Transl. Neurosci. Clin.

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KEYWORDSAlzheimer's disease; cell therapy; stem cells; neurogenesis Alzheimer's disease (AD) is the most prevalent type of dementia, and its neuropathology is characterized by the deposition of insoluble β-amyloid (Aβ) peptides, intracellular neurofibrillary tangles, amyloid angiopathy, age-related brain atrophy, synaptic pathology, white matter rarefaction, granulovacuolar degeneration, neuron loss, and neuroinflammation. Although much is known about the neurobiology of AD, very few conventional therapies are available to arrest or slow the disease. There is an urgent need for novel therapeutic approaches for AD. AD subjects have significantly fewer viable precursor cells in the hippocampus compared with age-matched healthy control subjects. However, the viable precursor cells that remain in AD and age-matched healthy control brain specimens can be induced to differentiate. To facilitate or mimic the natural compensatory effect in AD, cell therapy, including endogenous and exogenous stem cells, has been considered in AD. In this review, we focus on the history and development of cell therapy in AD, and consider the role of cell therapy as a potential treatment for AD.Citation Qiao LY, Huang HY, Chen L. Cell-based therapy in Alzheimer's disease: Current knowledge and perspective. Transl. Neurosci. Clin. 2016, 2(1): 50-58.

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“…Also, embryonic stem cells (ESCs) spontaneously differentiated to form DA cells which rescued cerebral function following transplantation into the rat striatum of PD [29]. For the Alzheimer's disease (AD), transplanted NSCs can differentiate into cholinergic neurons, which may play an important role in the therapeutic effects of transplanted NSCs [30]. Moreover, NSCs are demonstrated selectively migrated into lesioned brain sites, differentiated into new neurons and glial cells, and improved the functional deficits after intravenous transplantation in rat models of ischemia [31,32] and brain tumors such as glioblastoma and medulloblastoma [33].…”

Section: Stem Cell-based Cell Therapy In Brain Diseases: An Overviewmentioning

confidence: 99%