Effects of enhanced cerebrospinal fluid levels of vasopressin, vasopressin antagonist or vasoactive intestinal polypeptide on circadian sleep-wake rhythm in the rat

Kruisbrink, J.; Mirmiran, M.; Woude, T.P. van der; Boer, G.J.

doi:10.1016/0006-8993(87)90570-1

Cited by 64 publications

(18 citation statements)

References 52 publications

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“…Previous studies have shown that AVP may have a functional role in the control of the sleep-wake rhythm and the diurnal rhythms of corticosterone secretion. Infusion of AVP or AVP antagonists with an osmotic pump into the third ventricle significantly altered the sleep-wake pattern in the rat (Kruisbrink et al, 1987). It was also shown that the AVP levels in the CSF affect the arousal state of the rat in the dark period (Arnauld et al, 1989).…”

Section: Discussionmentioning

confidence: 93%

Suprachiasmatic Nuclei Grafts Restore the Circadian Rhythm in the Paraventricular Nucleus of the Hypothalamus

2004

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The mammalian suprachiasmatic nucleus (SCN) controls the circadian rhythm of many physiological and behavioral events by an orchestrated output of the electrical activity of SCN neurons. We examined the propagation of output signals from the SCN into the hypothalamus, especially into the region of the paraventricular nucleus, through multimicroelectrode recordings using acute and organotypic brain slices. Circadian rhythms in spontaneous firing rate with a period close to 24 hr were demonstrated in the SCN, in directly adjacent hypothalamic regions, and in the region of the paraventricular nucleus of the hypothalamus, an important center for the integration of neuroendocrine, homeostatic, and autonomic functions. The activity rhythms recorded from structures outside of the SCN were in phase with the rhythms in the SCN. Cyclic information in the hypothalamus was lost after ablation of the SCN but could be restored by SCN grafts, indicating that a humoral factor is responsible for the restoration of circadian rhythmicity in the absence of neural connections. Periodic application of arginine-vasopressin (AVP) provided evidence that AVP can induce rhythmicity in the hypothalamus. These data indicate that the SCN uses a dual (neuronal and humoral) mechanism for communication with its targets in the brain.

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Section: Discussionmentioning

confidence: 93%

Suprachiasmatic Nuclei Grafts Restore the Circadian Rhythm in the Paraventricular Nucleus of the Hypothalamus

2004

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“…This may have a physiological role, since oxytocin concentrations in the cerebrospinal fluid (CSF) show a diurnal rhythm (21) a n d could contribute t o the regulation of sleep-wake cycles in a similar way t o that recently proposed for vasopressin (22). In addition, oxytocin has recently been implicated as a stress hormone (23), and it is possible that changes in CSF oxytocin might play a role in the arousing effect of stressful stimuli.…”

Section: -mentioning

confidence: 94%

Effect of Centrally Administered Oxytocin on the Association Between Cortical Electroencephalogram and Milk Ejection in the Rat

Wakerley

Foreman

Ingram

1989

J Neuroendocrinology

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The milk-ejection reflex of the rat is closely associated with synchronized activity of the cortical electroencephalogram (EEG), and the frequency of milk ejections has been shown to be greatly facilitated by central oxytocin. The following experiments were undertaken to examine the changes in the EEG during facilitation of the reflex by central oxytocin. lntracerebroventricular injection of 1 mU (2.2 ng) oxytocin during suckling caused a rapid increase in the frequency of milk ejections but no change in the predominantly synchronized pattern of the EEG. However, after a delay (11.3+0.8 min, meankSE) there appeared to be an increasing proportion of desynchronization, which correlated with cessation of the facilitated milk-ejection responses. Hence, the observed EEG desynchronization may signal activation of mechanisms inhibitory to the milk-ejection reflex.In the absence of the suckling stimulus oxytocin also caused a change to desynchronization. However, this effect was more pronounced and commenced after a much shorter latency (1.7k0.4 min, mean kSE; P

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“…Underscoring the role of VP for the expression of behavioral rhythms are the findings that it enhanced the amplitude of the sleep-wake rhythm in rats (Kruisbrink et al, 1987) and that the substance is diminished in several brain areas of aged animals who show a tendency towards an attenuation of circadian rhythmicity (Brock, 1985;Roozendaal et al, 1987) There is one other recent study (Gerkema et al, 1994) which showed a correlation between SCN VP-immunoreactivity and spontaneous circadian rhythmicity in voles, whose implications will be discussed below.…”

Section: The Significance Of Vasopressin For the Circadian Systemmentioning

confidence: 96%

Reduced Neurophysin Immunoreactivity in Rat Suprachiasmatic Nucleus Parallels Dissociation of Circadian Feeding Rhythm in Constant Light

Steinhorst¹,

Mai²,

Rietveld³

1996

Biological Rhythm Research

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Several distinct neuronal populations can be outlined in the suprachiasmatic nucleus (SCN) by employing immunohistochemistry. Understanding their interaction may serve as the key to the processes involved in the generation of circadian rhythms by the SCN.15 adult rats were exposed to constant dim light (LL) and 3 animals as controls to an LD 12:12 light schedule over 140 days. When sacrificed 10 of the LL-animals had lost their circadian feeding rhythm while 5 were free-running and the controls kept an entrained rhythm. The brains were immunohistochemically stained for myelin basic protein, neurophysin (NPH), vasoactive intestinal peptide, neuropeptide Y, synaptophysin and the leucocyte epitopes FAL and HNK-1.Demarcation of intensely and very intensely stained NPH-positive areas by subjective gray-leveldiscrimination and computerized area measurement revealed that in rhythmic rats (n=8) the areas containing the stained material were twice as large (0.06 ± 0.03 mm2 vs. 0.028 ± 0.027 mm2; p≤0.05) than in arrhythmic animals.It is hypothesized that low NPH-contents in arrhythmic animals reflect arrest of the 'clockwork' in the SCN at circadian time 12:00.

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Effects of enhanced cerebrospinal fluid levels of vasopressin, vasopressin antagonist or vasoactive intestinal polypeptide on circadian sleep-wake rhythm in the rat

Cited by 64 publications

References 52 publications

Suprachiasmatic Nuclei Grafts Restore the Circadian Rhythm in the Paraventricular Nucleus of the Hypothalamus

Suprachiasmatic Nuclei Grafts Restore the Circadian Rhythm in the Paraventricular Nucleus of the Hypothalamus

Effect of Centrally Administered Oxytocin on the Association Between Cortical Electroencephalogram and Milk Ejection in the Rat

Reduced Neurophysin Immunoreactivity in Rat Suprachiasmatic Nucleus Parallels Dissociation of Circadian Feeding Rhythm in Constant Light

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