Effects of enriched environment on animal models of neurodegenerative diseases and psychiatric disorders

Laviola, Giovanni; Hannan, Anthony J.; Macrı̀, Simone; Solinas, Marcello; Jaber, Mohamed

doi:10.1016/j.nbd.2008.05.001

Cited by 270 publications

(205 citation statements)

References 103 publications

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“…We first analyzed whether the antidepressant effect of EE, as measured in a Porsolt test of forced swimming (learned helplessness), is distinct in naive animals when compared with animals pre-exposed to the same Porsolt test before the start of a long time period of EE. As expected (Laviola et al, 2008;Llorens-Martin et al, 2007;Porsolt et al, 1978), EE had an antidepressant effect that could be measured by the reduction in the immobility time. Pre-exposure to the same stressor (the initial Porsolt test) in control non-enriched animals led to an exacerbated effect in the second (final) Porsolt test, reflected as an increase in the immobility time.…”

Section: Discussionsupporting

confidence: 79%

“…Moreover, in the long-term, such activity has a direct impact on the ability to cope with life events, known as animal's cognitive reserve (Mandolesi et al, 2008;Milgram et al, 2006) and neurogenic reserve (Kempermann, 2008), respectively. Indeed, these contrasting paradigms influence the individual's ability to cope with stress and depression (Greer and Trivedi, 2009;Laviola et al, 2008;Mora et al, 2007), specifically in relation to their effects on adult neurogenesis (Navailles et al, 2008;Schloesser et al, 2010). We now know that EE augments neurogenesis by specifically stimulating either the survival or proliferation of newborn neurons (Kempermann et al, 1997a(Kempermann et al, , b, 1998Olson et al, 2006;van Praag et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

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Antidepressant and Proneurogenic Influence of Environmental Enrichment in Mice: Protective Effects vs Recovery

Llorens‐Martin

Tejeda

Trejo

2011

Neuropsychopharmacol

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Physical-cognitive activity has long-lasting beneficial effects on the brain and on behavior. Environmental enrichment (EE) induces brain activity known to influence the behavior of mice, as measured in learned helplessness paradigms (forced swim test), and neurogenic cell populations in the hippocampal dentate gyrus. However, it is not completely clear whether the antidepressant and proneurogenic effects of EE are different in animals that are naive or pre-exposed to the stress inducing helplessness, and if this depends on the type of stressor. It also remains unclear whether differential effects are exerted on distinct neurogenic subpopulations. We found that EE has a protective effect in adult female mice (C57BL/6J) when exposed twice to the same stressor (forced swim test) but it has no influence on recovery. The repeated exposure to this stressor was analyzed together with the effects of EE on different neurogenic populations distinguished by age and differentiation state. Younger cells are more sensitive and responsive to the conditions, both the positive and negative effects. These results are relevant to identify the cell populations that are the targets of stress, depression, and enrichment, and that form part of the mechanism responsible for mood dysfunctions.

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Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Antidepressant and Proneurogenic Influence of Environmental Enrichment in Mice: Protective Effects vs Recovery

Llorens‐Martin

Tejeda

Trejo

2011

Neuropsychopharmacol

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“…These findings may also have implications for social policy decisions surrounding addiction [for example, providing support for the use of ''drug courts,'' which offer drugaddicted criminal offenders communitybased treatment options unavailable to individuals in the general court system (19)]. Finally, these findings join a growing body of work suggesting beneficial effects of environmental enrichment in animal models of other neuropsychiatric conditions, including depression and Huntington and Alzheimer diseases (20). Such findings highlight the importance of the role of environmental conditions in disease phenotype, both in animal models and in the clinic.…”

Section: Remaining Questions and Implicationsmentioning

confidence: 76%

Undoing cocaine's consequences on behavior and brain

Setlow¹

2008

Proc. Natl. Acad. Sci. U.S.A.

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“…Abundant experimental evidence shows that EE is beneficial in various animal models of neurodegenerative disorders such as stroke and Alzheimer's disease [16,17]. Environmental enrichment also induces neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity to mice [18,19] and improves motor function after unilateral 6-OHDA injection in rats [20].…”

Section: Introductionmentioning

confidence: 99%

Effect of Resveratrol as Caloric Restriction Mimetic and Environmental Enrichment on Neurobehavioural Responses in Young Healthy Mice

Muhammad

Magaji

Mohammed

et al. 2014

Advances in Neuroscience

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Caloric restriction and environmental enrichment have been separately reported to possess health benefits such as improvement in motor and cognitive functions. Resveratrol, a natural polyphenolic compound, has been reported to be caloric restriction mimetic. This study therefore aims to investigate the potential benefit of the combination of resveratrol as CR and EE on learning and memory, motor coordination, and motor endurance in young healthy mice. Fifty mice of both sexes were randomly divided into five groups of 10 animals each: group I animals received carboxymethylcellulose (CMC) orally per kg/day (control), group II animals were maintained on every other day feeding, group III animals received resveratrol 50 mg/kg, suspended in 10 g/L of (CMC) orally per kg/day, group IV animals received CMC and were kept in an enriched environment, and group V animals received resveratrol 50 mg/kg and were kept in EE. The treatment lasted for four weeks. On days 26, 27, and 28 of the study period, the animals were subjected to neurobehavioural evaluation. The results obtained showed that there was no significant change ( > 0.05) in neurobehavioural responses in all the groups when compared to the control which indicates that 50 mg/kg of resveratrol administration and EE have no significant effects on neurobehavioural responses in young healthy mice over a period of four weeks.

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Effects of enriched environment on animal models of neurodegenerative diseases and psychiatric disorders

Cited by 270 publications

References 103 publications

Antidepressant and Proneurogenic Influence of Environmental Enrichment in Mice: Protective Effects vs Recovery

Antidepressant and Proneurogenic Influence of Environmental Enrichment in Mice: Protective Effects vs Recovery

Undoing cocaine's consequences on behavior and brain

Effect of Resveratrol as Caloric Restriction Mimetic and Environmental Enrichment on Neurobehavioural Responses in Young Healthy Mice

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