Effects of Enteromyxum scophthalmi experimental infection on the neuroendocrine system of turbot, Scophthalmus maximus (L.)

Losada, Ana; Bermúdez, Roberto; Faílde, L.D.; Giancamillo, A. Di; Domeneghini, C.; Quiroga, María Isabel

doi:10.1016/j.fsi.2014.08.011

Cited by 15 publications

(21 citation statements)

References 54 publications

(62 reference statements)

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“…The inflammatory infiltration is evident, although not always related to a high number of parasites. Infiltrates are mainly composed by intraepithelial lymphocytes and mixed inflammatory cells in the lamina propria-submucosa, where the presence of melanomacrophage aggregates has also been occasionally reported (García, 1999; Sitjà-Bobadilla et al, 2006; Bermúdez et al, 2010; Losada et al, 2014b). At this stage the normal architecture of the gut starts to show pathological evidences, represented by a scalloped shape of the lining epithelium (Bermúdez et al, 2010; Losada et al, 2014a).…”

Section: Turbot Enteromyxosismentioning

confidence: 99%

“…NES plays a key role in the digestive function and alimentary behavior, but it is also involved in the coordination of the immune response through its interactions with the immune system (Palmer and Greenwood-Van Meerveld, 2001). A large set of NES hormones/transmitters was studied in infected and non-infected fish by immunohistochemistry, finding an increased presence of molecules that boost the immune response in the intestine of diseased fish (Bermúdez et al, 2007; Losada et al, 2014b). The implications of the inflammatory reaction in the pathogenesis of diseases associated to catarrhal enteritis are well documented in mammals (Peterson and Artis, 2014; Kamekura et al, 2015; Williams et al, 2015).…”

Section: Turbot Enteromyxosismentioning

confidence: 99%

See 1 more Smart Citation

Integrating Genomic and Morphological Approaches in Fish Pathology Research: The Case of Turbot (Scophthalmus maximus) Enteromyxosis

et al. 2019

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Enteromyxosis, caused by Enteromyxum scophthalmi, is one of the most devastating diseases stemming from myxozoan parasites in turbot (Scophthalmus maximus L.), being a limiting factor for its production. The disease develops as a cachectic syndrome, associated to catarrhal enteritis and leukocytic depletion, with morbidity and mortality rates usually reaching 100%. To date, no effective treatment exists and there are different unknown issues concerning its pathogenesis. The gross and microscopic lesions associated to enteromyxosis have been thoroughly described, and several morphopathological studies have been carried out to elucidate the mechanisms of this host-parasite interaction. More recently, efforts have been focused on a multidisciplinary approach, combining histopathology and transcriptome analysis, which has provided significant advances in the understanding of the pathogenesis of this parasitosis. RNA-Seq technology was applied at early and advanced stages of the disease on fishes histologically evaluated and classified based on their lesional degree. In the same way, the transcriptomic data were analyzed in relation to the morphopathological picture and the course of the disease. In this paper, a comprehensive review of turbot enteromyxosis is presented, starting from the disease description up to the most novel information extracted by an integrated approach on the infection mechanisms and host response. Further, we discuss ongoing strategies toward a full understanding of host-pathogen interaction and the identification of suitable biomarkers for early diagnosis and disease management strategies.

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Section: Turbot Enteromyxosismentioning

confidence: 99%

Section: Turbot Enteromyxosismentioning

confidence: 99%

Integrating Genomic and Morphological Approaches in Fish Pathology Research: The Case of Turbot (Scophthalmus maximus) Enteromyxosis

et al. 2019

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“…Somatostatin is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone and most hormones of the gastrointestinal tract (Feifel & Vaccarino ). Somatostatin (SST) may also affect the immune response of fish (Losada, Bermúdez, Faílde, Di Giancamillo, Domeneghini & Quiroga ). Numerous studies have showed that SST is presented in the brain, digestive tract and other peripheral organs or systems of vertebrates, including fish (Lee & Ku ; Dong, Li & Lin ; Chen et al .…”

Section: Discussionmentioning

confidence: 99%

An immunohistochemical study on endocrine cells in the neuroendocrine system of the digestive tract of milkfish Chanos chanos (Forsskal, 1775)

et al. 2016

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In this study, several kinds of endocrine cells which produce neuropeptides and hormones have been identified and located in the digestive tract of milkfish (Chanos chanos) by the immunohistochemical technique. The oesophagus, stomach (cardiacus, fundic and pyloric regions), pyloric caeca, intestine (anterior, middle and posterior regions) and rectum were divided from the digestive tract of milkfish. The distribution and frequency of the endocrine cells produced these neuropeptides and hormones including gastrin, cholecystokinin, leuenkephalin, neuropeptide Y and somatostatin were described in these segments. Endocrine cells containing all neuropeptides and hormones immunoreactivities were present in the anterior intestine region, but no reaction was found in oesophagus. Only a few L-ENK-and SST-immunoreactive cells were detected in the pyloric caeca. Large numbers of SST-immunoreactive cells were observed in the stomach with no immunoreactivities to other neuropeptides and hormones. Two different types of endocrine cells were founded in the intestine and pyloric caeca. These results indicate that the anterior intestine region may be the main region of food digestion and absorption, and the neuropeptides and hormones regulate the food intake process by different ways in milkfish.

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“…There have been only few studies on parasitic fauna of Scophthalmus rhombus. The parasites recovered from this fish include a myxozoan intestinal parasite Enteromyxum scophthalmi (see Losada et al 2014), tapeworms Bothriocephalus scorpii (see Renaud et al 1984), and B. andresi, the trypanorhynch mesenteric cestode Nybelinia lingualis, the digenean Derogenes varicus, the acantocephalan Acanthocephaloides propinquus (see Eiras 2016), and two species of copepods, Lepeophtheirus hippoglossi (see Hayward and Ryland 2003) and L. europaensis (see Dawson et al 2000). However, data from the Baltic Sea are lacking.…”

Section: Discussionmentioning

confidence: 99%

Three new records of fishes and their parasite fauna from Pomeranian Bay, Baltic Sea

Więcaszek¹,

Sobecka²,

Keszka³

et al. 2019

Acta Ichthyol. Piscat.

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This paper reports the occurrence of three new fish species, extremely rare in the Baltic Sea, and provides new data on their parasite fauna. The fish collected were Barbus barbus (Linnaeus, 1758), Salvelinus fontinalis (Mitchill, 1814), and Scophthalmus rhombus (Linnaeus, 1758). Their taxonomic identity was confirmed through genetic analyses using DNA extracted from fin clips. The stomach contents were examined, and age was determined by otolith or scale readings. Parasitological examinations focused on the skin, vitreous humour, eye lenses, mouth and nasal cavities, gills, gonads, viscera, and muscles. Furthermore, the changes of fish species composition over 20 years in Pomeranian Bay were analysed. The sequence comparisons against GenBank records revealed that sequences obtained for B. barbus and S. rhombus from Pomeranian Bay represent new rhodopsin barcodes. Record of the juvenile B. barbus in this study is the first in the Baltic Sea. Scophthalmus rhombus is a new host for the ciliate Trichodina jadranica, while Neogobius melanostomus (Pallas, 1814) is a new food item in the diet of S. rhombus in the Baltic Sea. Acanthocephalan Pomphorhynchus laevis found in the adult specimen of B. barbus and myxozoan Myxobolus musculi, noted in the juvenile specimen, have not been recorded previously in this fish species in Polish waters. Species collected as bycatch can potentially be used for monitoring potential changes in the overall fish community structure and biodiversity.

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Effects of Enteromyxum scophthalmi experimental infection on the neuroendocrine system of turbot, Scophthalmus maximus (L.)

Cited by 15 publications

References 54 publications

Integrating Genomic and Morphological Approaches in Fish Pathology Research: The Case of Turbot (Scophthalmus maximus) Enteromyxosis

Integrating Genomic and Morphological Approaches in Fish Pathology Research: The Case of Turbot (Scophthalmus maximus) Enteromyxosis

An immunohistochemical study on endocrine cells in the neuroendocrine system of the digestive tract of milkfish Chanos chanos (Forsskal, 1775)

Three new records of fishes and their parasite fauna from Pomeranian Bay, Baltic Sea

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