Effects of Environmental Exposures on Fetal and Childhood Growth Trajectories

Zheng, Tongzhang; Jie, Zhang; Sommer, Kathryn; Bassig, Bryan A.; Zhang, Xichi; Braun, Joe M.; Xu, Shuangjie; Boyle, Peter; Zhang, Bin; Shi, Kunchong; Buka, Stephen L.; Liu, Siming; Li, Yuanyuan; Qian, Zengmin; Dai, Min; Romano, Megan E.; Zou, Aifen; Kelsey, Karl T.

doi:10.1016/j.aogh.2016.01.008

Cited by 138 publications

(80 citation statements)

References 260 publications

(304 reference statements)

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“…Given the widespread exposure to cadmium, mercury, and lead, there have been a number of studies investigating the relationship between maternal body burden of these metals and adverse pregnancy outcomes (eg, spontaneous abortion, stillbirth, preterm labor, and low birth weight). As a result, there are now a number of epidemiological studies, which have reported that exposure to these heavy metals is associated with low birth weight 120,121. However, these results are not entirely consistent as a number of other studies have failed to find a similar association 121…”

Section: Metalsmentioning

confidence: 95%

Early-life chemical exposures and risk of metabolic syndrome

Long

Holloway

2017

DMSO

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The global prevalence of obesity has been increasing at a staggering pace, with few indications of any decline, and is now one of the major public health challenges worldwide. While obesity and metabolic syndrome (MetS) have historically thought to be largely driven by increased caloric intake and lack of exercise, this is insufficient to account for the observed changes in disease trends. There is now increasing evidence to suggest that exposure to synthetic chemicals in our environment may also play a key role in the etiology and pathophysiology of metabolic diseases. Importantly, exposures occurring in early life (in utero and early childhood) may have a more profound effect on life-long risk of obesity and MetS. This narrative review explores the evidence linking early-life exposure to a suite of chemicals that are common contaminants associated with food production (pesticides; imidacloprid, chlorpyrifos, and glyphosate) and processing (acrylamide), in addition to chemicals ubiquitously found in our household goods (brominated flame retardants) and drinking water (heavy metals) and changes in key pathways important for the development of MetS and obesity.

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Section: Metalsmentioning

confidence: 95%

Early-life chemical exposures and risk of metabolic syndrome

Long

Holloway

2017

DMSO

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“…In particular, many studies have shown that prenatal exposure to neurotoxic metals like arsenic, lead, and mercury, as well as under-or over-exposure to essential trace elements like zinc and manganese, are associated with perturbed fetal growth, adverse birth outcomes, 1 and cognitive and behavioral problems in later childhood. 2 Despite such mounting evidence showing the ill effects of gestational metals exposure, the biologic mechanisms linking such exposures to neurobehavioral outcomes are not well understood.…”

Section: Introductionmentioning

confidence: 99%

Prenatal exposure to neurotoxic metals is associated with increased placental glucocorticoid receptor DNA methylation

2017

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Epigenetic alterations related to prenatal neurotoxic metals exposure may be key in understanding the origins of cognitive and neurobehavioral problems in children. Placental glucocorticoid receptor (NR3C1) methylation has been linked to neurobehavioral risk in early life, but has not been examined in response to neurotoxic metals exposure despite parallel lines of research showing metals exposure and NR3C1 methylation each contribute to a similar set of neurobehavioral phenotypes. Thus, we conducted a study of prenatal neurotoxic metals exposure and placental NR3C1 methylation in a cohort of healthy term singleton pregnancies from Rhode Island, USA (n D 222). Concentrations of arsenic (As; median 0.02 ug/g), cadmium (Cd; median 0.03 mg/g), lead (Pb; median 0.40 mg/g), manganese (Mn; median 0.56 mg/g), mercury (Hg; median 0.02 mg/g), and zinc (Zn; 145.18 mg/g) measured in infant toenails were categorized as tertiles. Multivariable linear regression models tested the independent associations for each metal with NR3C1 methylation, as well as the cumulative risk of exposure to multiple metals simultaneously. Compared to the lowest exposure tertiles, higher levels of As, Cd, Pb, Mn, and Hg were each associated with increased placental NR3C1 methylation (all P<0.02). Coefficients for these associations corresponded with a 0.71-1.41 percent increase in NR3C1 methylation per tertile increase in metals concentrations. For Zn, the lowest exposure tertile compared with the highest tertile was associated with 1.26 percent increase in NR3C1 methylation (PD0.01). Higher cumulative metal risk scores were marginally associated with greater NR3C1 methylation. Taken together, these results indicate that prenatal exposure to neurotoxic metals may affect the offspring's NR3C1 activity, which may help explain cognitive and neurodevelopmental risk later in life.

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“…The other pollutants involve polycyclic aromatic hydrocarbons (PAHs), ground-level ozone (O 3 ), nitrogen dioxide (NO 2 ), sulfur dioxide (SO 2 ), nitric oxide (NO), and carbon monoxide (CO) (Zheng et al, 2016). In addition, the major sources of air pollutants are indoor cooking, motor vehicle emissions, construction and demolition actions, industrial combustions, and power plants (Lee et al, 2014).…”

mentioning

confidence: 99%

“…Inhalation of the polluted air is the chief pathway of exposure (Pronczuk-Garbino, 2007). Thus, all humans are exposed to these pollutions in particular in low-and middle-income countries (Zheng et al, 2016). …”

mentioning

confidence: 99%

The Maternal Thyroid Gland as A Sentinel Organ for A Development: Signs of The Possible Harm of Air Pollution in Development

2018

ARC Journal of Animal and Veterinary Sciences

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Effects of Environmental Exposures on Fetal and Childhood Growth Trajectories

Cited by 138 publications

References 260 publications

Early-life chemical exposures and risk of metabolic syndrome

Early-life chemical exposures and risk of metabolic syndrome

Prenatal exposure to neurotoxic metals is associated with increased placental glucocorticoid receptor DNA methylation

The Maternal Thyroid Gland as A Sentinel Organ for A Development: Signs of The Possible Harm of Air Pollution in Development

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