Effects of environmental pollutants on the mitochondrial and red cell membranes.

Abstract

Most environmental pollutants affect biological membranes more or less, resulting in an increase in permeability of mitochondrial and red cell membranes, which causes changes in potassium compartmentation, and also impairment of oxidative phosphorylation of mitochondria. Authors classified various environmental pollutants from the mode of action on biological membranes.

A brief review on the assessment of potential joint effects of complex mixtures of contaminants in the environment

“…Exposure to toxic chemicals can cause health problems by interacting with biomolecules, known as molecular initiating events, which can disrupt various downstream physiological processes. 120 Although small molecular chemicals, such as PAHs 121 and aromatic amines, 122 attack nucleotides, and others, e.g., halogenated benzene, 123 target cell membranes, proteins also play a role in mediating adverse effects of contaminants. 124 However, the current non-target screening method still focuses on PFAS-relevant compounds while the interactions between emerging chemicals and proteins are still not clear by the current methods.…”

Comparison of the response of bacterial luminescence and mitochondrial respiration to the effluent of an oil refinery

“…The metabolic functions of mitochondria are linked to their membranes [6][7][8]. Measurement of the rate of oxygen disappearance from a mitochondrial suspension is a sensitive method to study how well the electron transport system and the ATP-synthetase complex work.…”

Comparison of the Response of Bacterial Luminescence and Mitochondrial Respiration to the Effluent of an Oil Refinery

“…Shannon et al [5] suggested that in vitro measurements of respiration would be useful to study the toxic effects of a variety of environmental chemicals. The metabolic functions of mitochondria are linked to their membranes [6][7][8]. Measurement of the rate of oxygen disappearance from a mitochondrial suspension is a sensitive method to study how well the electron transport system and the ATP-synthetase complex work.…”