Effects of environmental tobacco smoke on perinatal outcomes: a retrospective cohort study

Crane, Joan; Keough, Montgomery; Murphy, Phil; Burrage, Lorraine; Hutchens, Donna

doi:10.1111/j.1471-0528.2011.02941.x

Cited by 67 publications

(42 citation statements)

References 15 publications

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“…This study is consistent with previous studies indicating that exposure to SHS during pregnancy significantly reduced birthweight. Other studies 5,11,28,34 showed an association between LBW and SHS.…”

Section: Exposure To Secondhand Smoke During Pregnancy and Lbwmentioning

confidence: 99%

“…SHS ϭ second hand smoke LBW ϭ low birthweight NR ϭ not reported pregnancy, 5,6 to quantity of exposure to SHS, 11,13,[24][25][26][27][28][29][30][31][32][33]35,36 and to cotinine level (Tables 1 and 2). 12,14,17,22,37 One study 10 confirmed that exposure to SHS during pregnancy was a cause of LBW and not merely an association.…”

Section: Exposure To Secondhand Smoke During Pregnancy and Lbwmentioning

confidence: 99%

“…[15][16][17] Exposure to SHS during pregnancy may also cause higher rates of attention deficit hyperactivity disorder, asthma, and childhood cancers. 8,11 LBW is a worldwide problem both in developed countries and in developing countries. The World Health Organization defines LBW as any birthweight Ͻ 2,500 g. 13,[18][19][20] The more than 20 million LBW infants born annually worldwide, 96% of whom are born in developing countries, represent 16% of all births.…”

Section: Introductionmentioning

confidence: 99%

“…7,8 According to the World Health Organization, exposure to SHS caused an estimated 603,000 premature deaths around the world during 2004. 9 Exposure to SHS during pregnancy has been associated with many complications on mother, fetus, and infant, including fetal growth restriction, 10 intrauterine growth restriction, spontaneous abortion, 10 miscarriage, 10 stillbirth, 11 preterm birth, low birthweight (LBW), 10,12,13 and sudden infant death syndrome. 10,12,13 Exposure to SHS during pregnancy has also been associated with increased concentrations of nicotine and cotinine (the primary metabolite of nicotine) in the amniotic fluid and in the serum or urine of the mother and newborn.…”

Section: Introductionmentioning

confidence: 99%

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Association Between Exposure to Secondhand Smoke During Pregnancy and Low Birthweight: A Narrative Review

2014

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Exposure to secondhand smoke (SHS) during pregnancy may have adverse effects on the mother and infant. This study investigates the association of maternal exposure to SHS with low birthweight (LBW) in infants. Smoking during pregnancy has been linked to multiple complications for both mother and infant. To examine association of LBW and environmental tobacco smoke exposure during pregnancy, we reviewed 20 articles. Articles were accessed using the following electronic databases: CINAHL Plus with full text (EBSCO), PubMed, Embase, and MEDLINE. The findings of this review revealed that maternal exposure to environmental smoke is correlated with LBW in infants as well as numerous other adverse effects. The majority of the studies found negative consequences of SHS on the birthweight of infants born to nonsmoking women. Thus, this review helps to confirm the association between maternal exposure to SHS and LBW in infants.

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Section: Exposure To Secondhand Smoke During Pregnancy and Lbwmentioning

confidence: 99%

Section: Exposure To Secondhand Smoke During Pregnancy and Lbwmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association Between Exposure to Secondhand Smoke During Pregnancy and Low Birthweight: A Narrative Review

2014

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“…Specifically, studies have associated maternal secondhand smoke exposure with low infant birth weight and congenital anomalies (Salmasi, Grady, Jones, McDonald, & Knowledge Synthesis, 2010), increased risk of stillbirth, small infant head circumference (Crane, Keough, Murphy, Burrage, & Hutchens, 2011), and SIDS (U.S. Department of Health and Human Services, 2006).…”

Section: Introductionmentioning

confidence: 99%

Low-level maternal exposure to nicotine associates with significant metabolic perturbations in second-trimester amniotic fluid

Fischer

Lili

et al. 2017

Environment International

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Decades of public health research have documented that smoking in pregnancy poses significant health risks to both mother and child. More recent studies have shown that even passive maternal exposure to secondhand smoke associates with negative birth outcomes. However, the mechanisms linking exposure to outcomes have remained obscure. As a first step toward defining the metabolic consequence of low-level nicotine exposure on fetal development, we conducted an untargeted metabolomic analysis of 81 paired samples of maternal serum and amniotic fluid collected from karyotypically normal pregnancies in the second trimester. By comparing the m/z and retention times of our mass spectral features with confirmed standards, we identified cotinine, a nicotine derivative, and used the calculated cotinine concentrations to classify our maternal serum samples into exposure groups using previously defined cut-offs. We found that cotinine levels consistent with low-level maternal exposure to nicotine associated with distinct metabolic perturbations, particularly in amniotic fluid. In fact, the metabolic effects in amniotic fluid of ostensibly low-level exposed mothers showed greater overlap with perturbations previously observed in the sera of adult smokers than did the perturbations observed in the corresponding maternal sera. Dysregulated fetal pathways included aspartate and asparagine metabolism, pyrimidine metabolism, and metabolism of other amino acids. We also observed a strong negative association between level of maternal serum cotinine and acetylated polyamines in the amniotic fluid. Combined, these results confirm that low-level maternal nicotine exposure, indicated by a maternal serum cotinine level of 2–10 ng/mL, is associated with striking metabolic consequences in the fetal compartment, and that the affected pathways overlap those perturbed in the sera of adult smokers.

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Maternal passive smoking during pregnancy and neural tube defects in offspring: a meta-analysis

Wang

Zhang

et al. 2013

Arch Gynecol Obstet

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Effects of environmental tobacco smoke on perinatal outcomes: a retrospective cohort study

Cited by 67 publications

References 15 publications

Association Between Exposure to Secondhand Smoke During Pregnancy and Low Birthweight: A Narrative Review

Association Between Exposure to Secondhand Smoke During Pregnancy and Low Birthweight: A Narrative Review

Low-level maternal exposure to nicotine associates with significant metabolic perturbations in second-trimester amniotic fluid

Maternal passive smoking during pregnancy and neural tube defects in offspring: a meta-analysis

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