2018
DOI: 10.1016/j.chemosphere.2018.08.102
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Effects of environmentally relevant concentrations of tris (2-butoxyethyl) phosphate on growth and transcription of genes involved in the GH/IGF and HPT axes in zebrafish (Danio rerio)

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Cited by 47 publications
(18 citation statements)
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“…47 In addition, TBOEP has been found to induce malformations and growth delay, and reduce heart rate, body weight, and length. 25,48,49 While the biological mechanisms of the developmental toxicity of OPFRs are not clearly understood, a growing body of studies may provide clues to explain the potential mechanisms.…”
Section: Discussionmentioning
confidence: 99%
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“…47 In addition, TBOEP has been found to induce malformations and growth delay, and reduce heart rate, body weight, and length. 25,48,49 While the biological mechanisms of the developmental toxicity of OPFRs are not clearly understood, a growing body of studies may provide clues to explain the potential mechanisms.…”
Section: Discussionmentioning
confidence: 99%
“…52 In addition, the growth inhibition of zebrafish caused by TDCIPP and TBOEP exposure might be attributed to the downregulation of expression of GH/IGF axis-related genes. 25,46 Following exposure to some OPFRs, oxidative stress is enhanced and has also been proposed to have link with adverse pregnancy outcomes. 53,54 The fetus can be more affected by exposure to environmental pollutants than adults.…”
Section: Discussionmentioning
confidence: 99%
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“…73 In a similar way, Tris (2-butoxyethyl) phosphate (TBOEP) affected the growth of larvae zebrafish mainly through the regulation of GH/IGF axis rather than HPT axis. 74 In fact, ammonia is more likely to be accumulated in the liver rather than the thyroid gland since the liver is the largest metabolic and detoxified organ of the body. 19,75,76 The liver, meanwhile, is the primary site of production of IGF-1, whereas IGF-1 plays a central role in mediating somatic growth of fishes via the GH/IGF axis.…”
Section: Discussionmentioning
confidence: 99%
“…Zhu et al reported that growth performance reduction of zebrafish caused by Tris (1, 3‐dichloro‐2‐propyl) phosphate was involved with mRNA levels of GH/IGF‐axis genes, but not be related to the HPT axis 73 . In a similar way, Tris (2‐butoxyethyl) phosphate (TBOEP) affected the growth of larvae zebrafish mainly through the regulation of GH/IGF axis rather than HPT axis 74 . In fact, ammonia is more likely to be accumulated in the liver rather than the thyroid gland since the liver is the largest metabolic and detoxified organ of the body 19,75,76 .…”
Section: Discussionmentioning
confidence: 99%