Effects of environmentally relevant concentrations of the anti-inflammatory drug diclofenac in freshwater fish Rhamdia quelen

Guiloski, Izonete Cristina; Piancini, Laércio Dante Stein; Dagostim, Ana Carolina; Calado, Sabrina Loise de Morais; Fávaro, Luís Fernando; Boschen, Suelen Lúcio; Cestari, Marta Margarete; Cunha, Cláudio Da; Assis, Helena C. Silva de

doi:10.1016/j.ecoenv.2017.01.053

Cited by 95 publications

(17 citation statements)

References 61 publications

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“…Rhamdia quelen is a Neotropical freshwater fish, with a geographic distribution ranging from Mexico to Argentina (Gomes et al., 2000). This fish species has been used in the evaluation of environmental pollution using biomarkers related to the antioxidant system, metabolism, cytogenotoxicity, among others (Guiloski et al., 2017; Mathias et al., 2018; Pereira et al., 2016) and it is a species of commercial interest. However, there is still little knowledge about possible biomarkers related to its endocrine system, especially concerning the reproductive axis (Barcellos et al., 2001; Costa et al., 2010; Silva de Assis et al., 2018).…”

Section: Introductionmentioning

confidence: 99%

Cloning, partial sequencing and 17β‐estradiol modulation of hepatic vitellogenin gene of the Neotropical catfish Rhamdia quelen

et al. 2021

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Anthropogenic activities are constantly releasing xenobiotics such as pesticides, metals, and pharmaceuticals, into aquatic environments (Hachfi et al., 2012). Furthermore, several of these contaminants are endocrine disruptor chemicals (EDCs), which according to World Health Organization (WHO), are compounds able to affect the endocrine system and to promote damage to a healthy organism or to its offspring, in addition, to potentially affecting populations or subpopulations. The mechanism of action

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Section: Introductionmentioning

confidence: 99%

Cloning, partial sequencing and 17β‐estradiol modulation of hepatic vitellogenin gene of the Neotropical catfish Rhamdia quelen

et al. 2021

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“…Astyanax altiparanae (Garutti & Britski, 2000) Teleostei, Characidae, is a freshwater fish with a wide distribution in the Neotropical region; and presents an ecological and economic importance (Bertolucci et al, 2008). In addition to the biological model, the use of biomarkers is an advantageous tool to evaluate the sublethal effects in different levels of organization (Guiloski et al, 2017). Studies that use this approach have contributed to evaluate toxic effects of xenobiotics and to monitor contaminated areas (Vieira et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Biochemical and genotoxicity assessment of a polluted urban river using the native fish Astyanax altiparanae Garutti & Britski (Teleostei, Characidae)

Calado¹,

Andrade²,

Garrido³

et al. 2020

Ecotoxicol. Environ. Contam.

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Agriculture residues and domestic effluents are contaminants that reach aquatic ecosystems leading to toxic effects to environment and human health. These contaminants impacting mainly developing countries, due to precarious treatment of effluents and lack of legislation in the use of pesticides. Perequê River (South of Brazil) is impacted by pesticides (mainly glyphosate) and domestic effluents. The aims of this study were to analyze the concentration of glyphosate in water and sediments of Perequê River; and to evaluate the sublethal effects of the river contamination in Astyanax altiparanae using biomarkers. A sampling of water, sediment and fish were carried out in Perequê River (November/2016). The samples were collected in two sites, site 1 (S1) that is located on agriculture area and water catchment point; and site 2 (S2) located on the area with a domestic effluents influence. Water and sediment samples were used to glyphosate quantification. Fish were collected and tissues (brain, muscle, liver) were used to biochemical and genetic biomarkers. Glyphosate were quantified in S1, which is impacted by agriculture. Alterations in the liver biomarkers were not observed between the sites. However, the decrease in the AChE activity was observed in the S2, showing that the mixture of contaminants (urban and agriculture contaminants) can lead to anticholinesterasic effects. The sublethal effects observed can be a threat of environmental and human health.

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“…Pharmaceuticals and personal care products (PPCPs) comprise a diverse class of chemical compounds that have gained attention as chemicals of emerging concern (CECs) due to their widespread detection in aquatic environments [ 1 – 3 ] and because of their bioactive properties [ 4 – 6 ]. Although the ecological effects of many active pharmaceutical ingredients (APIs) are poorly known, several have been implicated in acute [ 7 – 8 ] and chronic toxicity [ 9 – 11 ] to biota. Direct toxic effects of APIs on microalgae have been observed, with effects varying according to the species and drug [ 12 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of metformin exposure on growth and photosynthetic performance in the unicellular freshwater chlorophyte, Chlorella vulgaris

2018

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Many pharmaceuticals have negative effects on biota when released into the environment. For example, recent work has shown that the commonly prescribed antidiabetic drug, metformin (N,N-dimethylbiguanide), has endocrine disrupting effects on fish. However, effects of metformin on aquatic primary producers are poorly known. We exposed cultured isolates of a freshwater chlorophyte, Chlorella vulgaris, to a range of metformin concentrations (0–767.9 mg L-1) to test the hypothesis that exposure negatively affects photosynthesis and growth. A cessation of growth, increase in non-photochemical quenching (NPQ, NPQmax), and reduced electron transport rate (ETR) were observed 24 h after exposure to a metformin concentration of 767.8 mg L-1 (4.6 mM). By 48 h, photosynthetic efficiency of photosystem II (Fv/Fm), α, the initial slope of the ETR-irradiance curve, and Ek (minimum irradiance required to saturate photosynthesis) were reduced. At a lower concentration (76.8 mg L-1), negative effects on photosynthesis (increase in NPQ, decrease in ETR) were delayed, occurring between 72 and 96 h. No negative effects on photosynthesis were observed at an exposure concentration of 1.5 mg L-1. It is likely that metformin impairs photosynthesis either through downstream effects from inhibition of complex I of the electron transport chain or via activation of the enzyme, SnRK1 (sucrose non-fermenting-related kinase 1), which acts as a cellular energy regulator in plants and algae and is an ortholog of the mammalian target of metformin, AMPK (5' adenosine monophosphate-activated protein kinase).

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Effects of environmentally relevant concentrations of the anti-inflammatory drug diclofenac in freshwater fish Rhamdia quelen

Cited by 95 publications

References 61 publications

Cloning, partial sequencing and 17β‐estradiol modulation of hepatic vitellogenin gene of the Neotropical catfish Rhamdia quelen

Cloning, partial sequencing and 17β‐estradiol modulation of hepatic vitellogenin gene of the Neotropical catfish Rhamdia quelen

Biochemical and genotoxicity assessment of a polluted urban river using the native fish Astyanax altiparanae Garutti & Britski (Teleostei, Characidae)

Effect of metformin exposure on growth and photosynthetic performance in the unicellular freshwater chlorophyte, Chlorella vulgaris

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