Effects of enzyme-inducing antiseizure medication on vitamin D dosing in adult veterans with epilepsy

Extending the reach of science – Talk in plain language

“…The example below is from an article studying the effects of enzyme-inducing antiseizure medication (ASM) on vitamin D dosing in patients with epilepsy. Original: “ This retrospective chart review aimed to characterize the pharmacokinetic interaction between ASMs and vitamin D so clinicians can better assess and monitor vitamin D supplementation in patients on these medications” [16] . Simplified: The goal of this study was to see if seizure medications interferred with vitamin D. This is important because low vitamin D levels cmay lead to bone loss in people with epilepsy.…”

“…Original: “ This retrospective chart review aimed to characterize the pharmacokinetic interaction between ASMs and vitamin D so clinicians can better assess and monitor vitamin D supplementation in patients on these medications” [16] .…”

“…This is noted by the following examples. Original : “The association of antiseizure medication (ASM) and bone density abnormalities has long been recognized, however, there remains a lack of consensus on efficacy and optimal vitamin D dosing in patients receiving enzyme inducing and non-inducing ASMs” [16] . Simplified : Patients who use seizure medications are more likely to have weaker bones than other people.…”

“…Original : “The association of antiseizure medication (ASM) and bone density abnormalities has long been recognized, however, there remains a lack of consensus on efficacy and optimal vitamin D dosing in patients receiving enzyme inducing and non-inducing ASMs” [16] .…”

“…For example, “The pharmacist gave the drug to the patient.” Using an active voice, the sentence is easier to read and understand. Original: “Patients with a diagnosis of epilepsy receiving supplemental vitamin D were included in this retrospective chart review” [16] . Active voice: In this study, researchers included patients with epilepsy who took vitamin D. …”