Effects of epidermal growth factor on serum zinc and plasma prostaglandin E2 levels of mice with pressure sores

Gönül, Bilge; Söylemezoğlu, Tülın; Yaniçoğlu, Lamia; Güvendik, Gülin

doi:10.1016/0090-6980(93)90030-b

Cited by 13 publications

(8 citation statements)

References 7 publications

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“…The role of prostaglandins in wound healing has previously been studied by using PGHS inhibitors (Brzozowski et al, 1993;LeDuc et al, 1993), by using exogenously added prostaglandin (Brzozowski et al, 1993), or by exogenously inducing the synthesis of prostaglandins (Gonul et al, 1993). These studies indicated that cyclooxygenases and their downstream products, prostaglandins, were involved in dermal wound healing.…”

Section: Discussionmentioning

confidence: 99%

“…This has been demonstrated by exogenously adding the stable PGE 2 analog 16,16-dimethyl prostaglandin E 2 -methyl ester (Brzozowski et al, 1993), PGHS inhibitors (Brzozowski et al, 1993;Dong et al, 1993;Fang et al, 1983;LeDuc et al, 1993;Sun et al, 2000), or agents that increase plasma PGE 2 levels (Gonul et al, 1993). There is some evidence to suggest that PGE 2 may be more important in the early stages of wound healing, causing increased fibrosis and decreased accumulation of macrophages by 7 days after injury (Talwar et al, 1996).…”

mentioning

confidence: 99%

“…The presence of PGE 2 or active PGHS enzyme has been reported to be beneficial to the healing process in various models of tissue repair (Brzozowski et al, 1993;Fang et al, 1983;Gonul et al, 1993;LeDuc et al, 1993). This has been demonstrated by exogenously adding the stable PGE 2 analog 16,16-dimethyl prostaglandin E 2 -methyl ester (Brzozowski et al, 1993), PGHS inhibitors (Brzozowski et al, 1993;Dong et al, 1993;Fang et al, 1983;LeDuc et al, 1993;Sun et al, 2000), or agents that increase plasma PGE 2 levels (Gonul et al, 1993).…”

mentioning

confidence: 99%

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Both Constitutive and Inducible Prostaglandin H Synthase Affect Dermal Wound Healing in Mice

Laulederkind

Thompson-Jaeger

Goorha

et al. 2002

Laboratory Investigation

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SUMMARY:In an attempt to define the roles of prostaglandin H synthase 1 (PGHS-1, cyclooxygenase-1, COX-1) and prostaglandin H synthase 2 (PGHS-2, cyclooxygenase-2, COX-2) in wound healing, we investigated the healing of incisional dermal wounds in wild-type, PGHS-1 null, and PGHS-2 null mice. We measured tensile strength of the wounds, levels of PGHS-1 and PGHS-2 mRNA in the wound site, and histologic markers for the inflammatory, proliferative, and remodeling phases of wound healing. Although no gross visible differences were noted among healed wounds of the different mouse types, measurement of tensile strength showed that both PGHS-1 and PGHS-2 null wounds were weaker (75% and 70%, respectively) than wild-type wounds at 12 days after incision. At Day 8 the endothelial staining was 70% greater in the wounds of PGHS-2 null mice compared with their wild-type counterparts. In contrast at Day 12, staining for macrophages and myofibroblasts was less in PGHS-1 null wounds compared with wild-type and PGHS-2 null tissue. Compensatory expression of the alternate PGHS mRNA could be demonstrated by RT-PCR in the wounds of PGHS null mice on Days 1 and 4. We conclude that both PGHS-1 and PGHS-2 genes play distinct roles in the process of dermal wound healing. (Lab Invest 2002, 82:919 -927).

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Both Constitutive and Inducible Prostaglandin H Synthase Affect Dermal Wound Healing in Mice

Laulederkind

Thompson-Jaeger

Goorha

et al. 2002

Laboratory Investigation

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“…Therefore, we tested a mouse decubitus ulcer model. 32 In this model, GFP ϩ BMDCs were massively accumulated throughout the granulation tissues in the ulcer (Figure 3K-M). However, similar to the 2 models of acute wound healing, none of the vascular endothelium was stained for GFP, suggesting that BMDCs do not differentiate into endothelial cells in the decubitus ulcer model ( Figure 3N).…”

Section: Bmdcs Do Not Differentiate Into Endothelial Cells In Decubitmentioning

confidence: 99%

“…32 Briefly, mice were anesthetized, bilateral skin covering hind limbs was cut down, and 5-mm length of bilateral sciatic nerve was removed. Mice were housed free in less straw-bedded cages.…”

Section: Decubitus Ulcer Modelmentioning

confidence: 99%

Bone marrow-derived cells serve as proangiogenic macrophages but not endothelial cells in wound healing

Okuno¹,

Nakamura‐Ishizu²,

Kishi³

et al. 2011

Blood

102

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Bone marrow-derived cells (BMDCs) contribute to postnatal vascular growth by differentiating into endothelial cells or secreting angiogenic factors. However, the extent of their endothelial differentiation highly varies according to the angiogenic models used. Wound healing is an intricate process in which the skin repairs itself after injury. As a process also observed in cancer progression, neoangiogenesis into wound tissues is profoundly involved in this healing process, suggesting the contribution of BMDCs. However, the extent of the differentiation of BMDCs to endothelial cells in wound healing is unclear. In this study, using the green fluorescent protein-bone marrow chimeric experiment and high resolution confocal microscopy at a single cell level, we observed no endothelial differentiation of BMDCs in 2 acute wound healing models (dorsal excisional wound and ear punch) and a chronic wound healing model (decubitus ulcer). Instead, a major proportion of BMDCs were macrophages. Indeed, colony-stimulating factor 1 (CSF-1) inhibition depleted approximately 80% of the BMDCs at the wound healing site. CSF-1-mutant (CSF-1 op/op ) mice showed significantly reduced neoangiogenesis into the wound site, supporting the substantial role of BMDCs as macrophages. Our data show that the proangiogenic effects of macrophages, but not the endothelial differentiation, are the major contribution of

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Zink (Zn)

Ekmekçioğlu¹

Essenzielle Spurenelemente

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Effects of epidermal growth factor on serum zinc and plasma prostaglandin E2 levels of mice with pressure sores

Cited by 13 publications

References 7 publications

Both Constitutive and Inducible Prostaglandin H Synthase Affect Dermal Wound Healing in Mice

Both Constitutive and Inducible Prostaglandin H Synthase Affect Dermal Wound Healing in Mice

Bone marrow-derived cells serve as proangiogenic macrophages but not endothelial cells in wound healing

Zink (Zn)

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