Effects of Epidural Steroid Injections on Blood Glucose Levels in Patients With Diabetes Mellitus

Even, Jesse L.; Crosby, Colin G.; Song, Yanna; McGirt, Matthew J.; Devin, Clinton J.

doi:10.1097/brs.0b013e31821fd21f

Cited by 73 publications

(48 citation statements)

References 14 publications

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“…It has been demonstrated that a significant elevation in blood glucose levels occurs after epidural steroid injections, a common treatment for patients with lumbar radiculopathy [59] . A transient rise of nearly 80% occurred, however the serum glucose level normalized with 48 h of the procedure.…”

Section: Nonsurgical Treatmentmentioning

confidence: 99%

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Diabetes and its negative impact on outcomes in orthopaedic surgery

Wukich

2015

WJO

115

103

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An estimated 285 million adults (aged 20-79 years) worldwide were diagnosed to have diabetes mellitus (DM) in 2010, and this number is projected to grow to 439 million adults by the year 2030. Orthopaedic surgeons, regardless of their subspecialty interest, will encounter patients with DM during their career since this epidemic involves both developed and emerging countries. Diabetes results in complications affecting multiple organ systems, potentially resulting in adverse outcomes after orthopaedic surgery. The purpose of this review is to discuss the pathophysiology of DM and its potential for impacting orthopaedic surgery patients. Diabetes adversely affects the outcome of all orthopaedic surgery subspecialties including foot and ankle, upper extremity, adult reconstructive, pediatrics, spine surgery and sports medicine. Poorly controlled diabetes negatively impacts bone, soft tissue, ligament and tendon healing. It is the complications of diabetes such as neuropathy, peripheral artery disease, and end stage renal disease which contributes to adverse outcomes. Well controlled diabetic patients without comorbidities have similar outcomes to patients without diabetes. Orthopaedic surgeons should utilize consultants who will assist in inpatient glycemic management as well as optimizing long term glycemic control.

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Section: Nonsurgical Treatmentmentioning

confidence: 99%

“…A transient rise of nearly 80% occurred, however the serum glucose level normalized with 48 h of the procedure. Diabetic patients should be advised that a temporary elevation in blood glucose is likely post injection [59] .…”

Section: Nonsurgical Treatmentmentioning

confidence: 99%

Diabetes and its negative impact on outcomes in orthopaedic surgery

Wukich

2015

WJO

115

103

View full text Add to dashboard Cite

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“…There are studies that suggest a possible systemic effect of steroids used in ESI. In these studies investigating the systemic effects of epidural and intraarticular glucocorticoid injections, a significant increase was reported in the glucose levels of diabetic and nondiabetic patients (27)(28)(29). In our study, a clinically insignificant increase in WBC values was found after both groups received ESI.…”

Section: Discussionmentioning

confidence: 37%

The effect of tramadol and tramadol + gabapentin combination in patients with lumbar disc herniation after epidural steroid injection

Pirbudak¹,

Çiçek²,

Işık³

et al. 2015

Turk J Med Sci

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Background/aim: To compare the effects of tramadol-only treatment and tramadol + gabapentin treatment in patients who had received an epidural steroid injection. Materials and methods:Forty patients with hernia disc-originated acute lumbar discogenic pain were evaluated. All patients received a single dose of steroid and local anesthesia mixture epidurally via the lumbar approach. In both groups, Group T (tramadol, n = 20) and Group TG (tramadol + gabapentin, n = 20), the injection dose was adjusted to 4 mL of triamcinolone acetonide and 0.25% bupivacaine mixture. Orally, 75 mg/day tramadol or 75 mg/day tramadol + 900 mg/day gabapentin were added to the treatment. Leukocyte, erythrocyte sedimentation rate, C-reactive protein, and urine serotonin levels were measured prior to and after treatment. The effectiveness of the treatment was evaluated by visual analog scale (VAS), Oswestry Disability Index (ODI), and straight leg elevation test (SLET).Results: Similar improvements in VAS, ODI, and SLET values were observed in both groups in the second week. The inflammation markers were not different after treatment, neither within the groups nor between the groups. Conclusion:This study revealed that tramadol + gabapentin treatment was not superior to tramadol treatment.

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“…W większości badań opisano przejściowy istotny wzrost stężenia glukozy we krwi i powrót glikemii do wartości prawidłowych po 2-3 dniach po iniekcji [61][62][63].…”

Section: Efekt Diabetogenny Glikokortykosteroidówunclassified

“…Bardzo interesujące wydają się próby zastosowania tej grupy leków inkretynowych w prewencji zaburzeń tolerancji glukozy u osób przyjmujących GS. Wykazano, że wlew eksenatydu zapobiegał dysfunkcji komórek wysp trzustkowych i hiperglikemii wywołanej krótkoterminowym podaniem GS [62]. Pojawiły się również doniesienia o korzystnym efekcie stosowania inhibitorów dipeptydylopeptydazy 4 (DPP-4) w cukrzycy posteroidowej [70,71].…”

Section: Leczenie Cukrzycy Posteroidowejunclassified

Glikokortykosteroidy a zaburzenia metabolizmu glukozy

Pisarczyk-Wiza

Zozulińska‐Ziółkiewicz²

2015

Diabetologia Kliniczna

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Effects of Epidural Steroid Injections on Blood Glucose Levels in Patients With Diabetes Mellitus

Cited by 73 publications

References 14 publications

Diabetes and its negative impact on outcomes in orthopaedic surgery

Diabetes and its negative impact on outcomes in orthopaedic surgery

The effect of tramadol and tramadol + gabapentin combination in patients with lumbar disc herniation after epidural steroid injection

Glikokortykosteroidy a zaburzenia metabolizmu glukozy

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