Effects of epinephrine and 17β-estradiol sulfate on transmembrane potentials of guinea pig cardiomyocytes

Abstract

Changes in the transmembrane potentials of guinea pig cardiomyocytes caused by epinephrine and 17~-estradiol sulfate are studied. It is shown that 17~-estradiol attenuates the effect of epinephrine on these cells.

Sex differences in endothelium-dependent reactions of rabbit arteries to elevated blood flow

“…Experimental, instrumental, clinical, and biochemical assays indicate that estrogens (at various routes of administration) decrease the tone of intact and precontracted coronary arteries [9]. Estrogens rapidly change the vascular tone by modulating electric properties of biological membranes and transmembrane ion permeability [1 ]. Dilation of the coronary vessels induced by steroid and nonsteroid estrogens does not depend on the adrenergic, cholinergic, and histaminergic mechanisms, but is related to the blockade of transmembrane Ca 2+ transport [13].…”